Reviewed, UniProtKB/Swiss-Prot P43909 (PHEA_LACLM)

Names and origin

Protein names

Recommended name:
    Prephenate dehydratase
      Short name=PDT
    EC=4.2.1.51

Gene names

Name:	pheA
Ordered Locus Names:	llmg_1924

Organism

Lactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]

Taxonomic identifier

416870 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate = phenylpyruvate + H2O + CO2.
Pathway	Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate dehydratase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Phenylalanine biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	prephenate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Prephenate dehydratase		PRO_0000119179
Regions
	Domain	2 – 178	177	Prephenate dehydratase
	Domain	192 – 269	78	ACT
Sites
	Site	171	1	Essential for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43909-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A11ED51557A0AD73	FASTA	279	31,030
	10 20 30 40 50 60 MKIAYLGPRG SFCSVVAEAA FKSEELYSYA TILDVIEAYN EGECDFALVP IENSTEGTVN 70 80 90 100 110 120 MSIDKIFHDS NAKVVAEFVL PISQNLLAVS KEQKIEHIYS HPQALAQTRV YLRKFYPQAQ 130 140 150 160 170 180 VEITESTSAA AEFVKNNPDL PAAAVANSFA AKMYDLEFIA ENIQDLAGNS TRFWLLGKEK 190 200 210 220 230 240 QSFDLNQTKD KVTLALTLPD NLPGALHKAI SVFAWRDIDM TKIESRPLRT RLGQYFFIID 250 260 270 LENNATNSLK IPYALEELAG LGVNVRLLGN YSVYSLGEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic aspects of aromatic amino acid biosynthesis in Lactococcus lactis." Griffin H.G., Gasson M.J. Mol. Gen. Genet. 246:119-127(1995) [PubMed: 7823907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MG1363 / F15876.
[2]	"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363." Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J. J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X78413 Genomic DNA. Translation: CAA55182.1. AM406671 Genomic DNA. Translation: CAL98493.1.
PIR	S52582.
RefSeq	YP_001033189.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P43909.
Genome annotation databases
GeneID	4798602.
GenomeReviews	Gene locus llmg_1924 in contig AM406671_GR.
KEGG	llm:llmg_1924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GLGNYFF.
Family and domain databases
InterPro	IPR001086. Preph_deHydtase. IPR018528. Preph_deHydtase_CS. [Graphical view]
Pfam	PF00800. PDT. 1 hit. [Graphical view]
PROSITE	PS00857. PREPHENATE_DEHYDR_1. 1 hit. PS00858. PREPHENATE_DEHYDR_2. 1 hit. PS51171. PREPHENATE_DEHYDR_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHEA_LACLM

Accession

Primary (citable) accession number: P43909
Secondary accession number(s): A2RMG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)