P43903 (QOR_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Quinone oxidoreductase
EC=1.6.5.5

Alternative name(s):
NADPH:quinone reductase

Gene names

Name:	qor
Ordered Locus Names:	PA0023

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	NADPH + 2 quinone = NADP+ + 2 semiquinone.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Quinone oxidoreductase		PRO_0000160903
Experimental info
	Sequence conflict	10	1	Y → C in CAA59375. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P43903 [UniParc]. Last modified December 8, 2000. Version 2. Checksum: 059A49962FA2CE2A	FASTA	325	35,095
	10 20 30 40 50 60 MAKRIQFAAY GGPEVLEYRD YQPAEPGPRE VRVRNRAIGL NFIDTYYRSG LYPAPGLPSG 70 80 90 100 110 120 LGSEGAGEVE AVGSEVTRFK VGDRVAYATG PLGAYSELHV LAEEKLVHLP DGIDFEQAAA 130 140 150 160 170 180 VMLKGLTTQY LLRQTYELRG GETILFHAAA GGVGLFACQW AKALGVQLIG TVSSPEKARL 190 200 210 220 230 240 ARQHGAWETI DYSHENVARR VLELTDGKKC PVVYDSVGKD TWETSLDCVA PRGLLVSFGN 250 260 270 280 290 300 ASGPVTGVNL GILSQKGSLY VTRPTLGSYA DTPEKLQAMA DELFGLIERG DIRIEINQRF 310 320 ALAEAARAHT ELAARRTTGS TVLLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and regulation of the Pseudomonas aeruginosa hemF gene encoding oxygen-dependent coproporphyrinogen III oxidase." Hungerer C., Troup B., Jahn D. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85015 Genomic DNA. Translation: CAA59375.1. AE004091 Genomic DNA. Translation: AAG03413.1.
PIR	D83644. S52923.
RefSeq	NP_248713.1. NC_002516.2.
3D structure databases
ProteinModelPortal	P43903.
SMR	P43903. Positions 2-325.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	880685.
GenomeReviews	Gene locus PA0023 in contig AE004091_GR.
KEGG	pae:PA0023.
PATRIC	19834240. VBIPseAer58763_0022.
Organism-specific databases
PseudoCAP	PA0023.
Phylogenomic databases
HOGENOM	HBG753318.
OMA	ENTQAMA.
ProtClustDB	CLSK865537.
Enzyme and pathway databases
BioCyc	PAER208964:PA0023-MONOMER.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00344.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QOR_PSEAE

Accession

Primary (citable) accession number: P43903

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	December 8, 2000
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program