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P43902 (TYRA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
T-protein

Including the following 2 domains:

  1. Chorismate mutase
    Short name=CM
    EC=5.4.99.5
  2. Prephenate dehydrogenase
    Short name=PDH
    EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:HI_1290
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Chorismate = prephenate.

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.

Subcellular location

Cytoplasm.

Sequence similarities

Contains 1 chorismate mutase domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377T-protein
PRO_0000119197

Regions

Domain1 – 9292Chorismate mutase
Domain101 – 364264Prephenate/arogenate dehydrogenase

Secondary structure

1 ................................................ 377
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43902 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 319722CFDFDE5791

FASTA37743,022
        10         20         30         40         50         60 
MSFMEALKDL RSEIDSLDRE LIQLFAKRLE LVSQVGKVKH QHGLPIYAPE REIAMLQARR 

        70         80         90        100        110        120 
LEAEKAGISA DLIEDVLRRF MRESYANENQ FGFKTINSDI HKIVIVGGYG KLGGLFARYL 

       130        140        150        160        170        180 
RASGYPISIL DREDWAVAES ILANADVVIV SVPINLTLET IERLKPYLTE NMLLADLTSV 

       190        200        210        220        230        240 
KREPLAKMLE VHTGAVLGLH PMFGADIASM AKQVVVRCDG RFPERYEWLL EQIQIWGAKI 

       250        260        270        280        290        300 
YQTNATEHDH NMTYIQALRH FSTFANGLHL SKQPINLANL LALSSPIYRL ELAMIGRLFA 

       310        320        330        340        350        360 
QDAELYADII MDKSENLAVI ETLKQTYDEA LTFFENNDRQ GFIDAFHKVR DWFGDYSEQF 

       370 
LKESRQLLQQ ANDLKQG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22939.1.
PIRH64114.
RefSeqNP_439442.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PV7X-ray2.00A/B81-377[»]
ProteinModelPortalP43902.
SMRP43902. Positions 92-370.
ModBaseSearch...

Protein-protein interaction databases

STRING71421.HI1290.

Protocols and materials databases

DNASU950220.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22939; AAC22939; HI_1290.
GeneID950220.
KEGGhin:HI1290.
PATRIC20191263. VBIHaeInf48452_1342.

Phylogenomic databases

eggNOGCOG0287.
KOK14187.
OMAQRFGEAI.
ProtClustDBPRK11199.

Enzyme and pathway databases

UniPathwayUPA00120; UER00203.
UPA00122; UER00961.

Family and domain databases

Gene3D1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
SSF48600. Chorismate_mut. 1 hit.
TIGRFAMsTIGR01799. CM_T. 1 hit.
PROSITEPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43902.

Entry information

Entry nameTYRA_HAEIN
AccessionPrimary (citable) accession number: P43902
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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