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P43902

- TYRA_HAEIN

UniProt

P43902 - TYRA_HAEIN

Protein

T-protein

Gene

tyrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Chorismate = prephenate.
    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    GO - Molecular functioni

    1. chorismate mutase activity Source: UniProtKB-EC
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chorismate metabolic process Source: InterPro
    2. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00120; UER00203.
    UPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-protein
    Including the following 2 domains:
    Chorismate mutase (EC:5.4.99.5)
    Short name:
    CM
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:HI_1290
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377T-proteinPRO_0000119197Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1290.

    Structurei

    Secondary structure

    1
    377
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi103 – 1064
    Turni107 – 1093
    Helixi111 – 12111
    Turni122 – 1243
    Beta strandi127 – 1304
    Helixi135 – 1373
    Helixi138 – 1425
    Beta strandi146 – 1505
    Helixi154 – 1563
    Helixi157 – 1648
    Helixi165 – 1673
    Beta strandi172 – 1765
    Helixi182 – 19110
    Beta strandi193 – 2019
    Beta strandi214 – 2218
    Helixi223 – 2253
    Helixi227 – 2359
    Beta strandi239 – 2424
    Helixi245 – 25511
    Helixi257 – 27014
    Helixi277 – 2826
    Helixi286 – 29914
    Helixi303 – 3108
    Helixi317 – 33519
    Helixi339 – 35315
    Helixi356 – 37015

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PV7X-ray2.00A/B81-377[»]
    ProteinModelPortaliP43902.
    SMRiP43902. Positions 92-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43902.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9292Chorismate mutasePROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 364264Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    KOiK14187.
    OMAiQANDSRQ.
    OrthoDBiEOG618R0Z.
    PhylomeDBiP43902.

    Family and domain databases

    Gene3Di1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTiSM00830. CM_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsiTIGR01799. CM_T. 1 hit.
    PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43902-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFMEALKDL RSEIDSLDRE LIQLFAKRLE LVSQVGKVKH QHGLPIYAPE    50
    REIAMLQARR LEAEKAGISA DLIEDVLRRF MRESYANENQ FGFKTINSDI 100
    HKIVIVGGYG KLGGLFARYL RASGYPISIL DREDWAVAES ILANADVVIV 150
    SVPINLTLET IERLKPYLTE NMLLADLTSV KREPLAKMLE VHTGAVLGLH 200
    PMFGADIASM AKQVVVRCDG RFPERYEWLL EQIQIWGAKI YQTNATEHDH 250
    NMTYIQALRH FSTFANGLHL SKQPINLANL LALSSPIYRL ELAMIGRLFA 300
    QDAELYADII MDKSENLAVI ETLKQTYDEA LTFFENNDRQ GFIDAFHKVR 350
    DWFGDYSEQF LKESRQLLQQ ANDLKQG 377
    Length:377
    Mass (Da):43,022
    Last modified:November 1, 1995 - v1
    Checksum:i319722CFDFDE5791
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22939.1.
    PIRiH64114.
    RefSeqiNP_439442.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22939; AAC22939; HI_1290.
    GeneIDi950220.
    KEGGihin:HI1290.
    PATRICi20191263. VBIHaeInf48452_1342.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22939.1 .
    PIRi H64114.
    RefSeqi NP_439442.1. NC_000907.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PV7 X-ray 2.00 A/B 81-377 [» ]
    ProteinModelPortali P43902.
    SMRi P43902. Positions 92-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1290.

    Protocols and materials databases

    DNASUi 950220.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22939 ; AAC22939 ; HI_1290 .
    GeneIDi 950220.
    KEGGi hin:HI1290.
    PATRICi 20191263. VBIHaeInf48452_1342.

    Phylogenomic databases

    eggNOGi COG0287.
    KOi K14187.
    OMAi QANDSRQ.
    OrthoDBi EOG618R0Z.
    PhylomeDBi P43902.

    Enzyme and pathway databases

    UniPathwayi UPA00120 ; UER00203 .
    UPA00122 ; UER00961 .

    Miscellaneous databases

    EvolutionaryTracei P43902.

    Family and domain databases

    Gene3Di 1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTi SM00830. CM_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsi TIGR01799. CM_T. 1 hit.
    PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiTYRA_HAEIN
    AccessioniPrimary (citable) accession number: P43902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3