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Protein

T-protein

Gene

tyrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. P-protein (pheA), T-protein (tyrA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Oxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

BRENDAi1.3.1.12. 2529.
UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:HI_1290
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

P43902:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191971 – 377T-proteinAdd BLAST377

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1290.

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi103 – 106Combined sources4
Turni107 – 109Combined sources3
Helixi111 – 121Combined sources11
Turni122 – 124Combined sources3
Beta strandi127 – 130Combined sources4
Helixi135 – 137Combined sources3
Helixi138 – 142Combined sources5
Beta strandi146 – 150Combined sources5
Helixi154 – 156Combined sources3
Helixi157 – 164Combined sources8
Helixi165 – 167Combined sources3
Beta strandi172 – 176Combined sources5
Helixi182 – 191Combined sources10
Beta strandi193 – 201Combined sources9
Beta strandi214 – 221Combined sources8
Helixi223 – 225Combined sources3
Helixi227 – 235Combined sources9
Beta strandi239 – 242Combined sources4
Helixi245 – 255Combined sources11
Helixi257 – 270Combined sources14
Helixi277 – 282Combined sources6
Helixi286 – 299Combined sources14
Helixi303 – 310Combined sources8
Helixi317 – 335Combined sources19
Helixi339 – 353Combined sources15
Helixi356 – 370Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PV7X-ray2.00A/B81-377[»]
ProteinModelPortaliP43902.
SMRiP43902.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92Chorismate mutasePROSITE-ProRule annotationAdd BLAST92
Domaini101 – 364Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST264

Sequence similaritiesi

In the C-terminal section; belongs to the prephenate/arogenate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105EHE. Bacteria.
COG0287. LUCA.
COG1605. LUCA.
KOiK14187.
OMAiQIQIWGA.
PhylomeDBiP43902.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR036263. Chorismate_II_sf.
IPR036979. CM_II_dom_sf.
IPR002701. CM_II_prokaryot.
IPR011277. CM_T.
IPR036291. NAD(P)-bd_dom_sf.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiView protein in SMART
SM00830. CM_2. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiView protein in PROSITE
PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

P43902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFMEALKDL RSEIDSLDRE LIQLFAKRLE LVSQVGKVKH QHGLPIYAPE
60 70 80 90 100
REIAMLQARR LEAEKAGISA DLIEDVLRRF MRESYANENQ FGFKTINSDI
110 120 130 140 150
HKIVIVGGYG KLGGLFARYL RASGYPISIL DREDWAVAES ILANADVVIV
160 170 180 190 200
SVPINLTLET IERLKPYLTE NMLLADLTSV KREPLAKMLE VHTGAVLGLH
210 220 230 240 250
PMFGADIASM AKQVVVRCDG RFPERYEWLL EQIQIWGAKI YQTNATEHDH
260 270 280 290 300
NMTYIQALRH FSTFANGLHL SKQPINLANL LALSSPIYRL ELAMIGRLFA
310 320 330 340 350
QDAELYADII MDKSENLAVI ETLKQTYDEA LTFFENNDRQ GFIDAFHKVR
360 370
DWFGDYSEQF LKESRQLLQQ ANDLKQG
Length:377
Mass (Da):43,022
Last modified:November 1, 1995 - v1
Checksum:i319722CFDFDE5791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22939.1.
PIRiH64114.
RefSeqiNP_439442.1. NC_000907.1.
WP_005694532.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22939; AAC22939; HI_1290.
GeneIDi950220.
KEGGihin:HI1290.
PATRICifig|71421.8.peg.1342.

Similar proteinsi

Entry informationi

Entry nameiTYRA_HAEIN
AccessioniPrimary (citable) accession number: P43902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families