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P43902

- TYRA_HAEIN

UniProt

P43902 - TYRA_HAEIN

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Protein

T-protein

Gene

tyrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

GO - Molecular functioni

  1. chorismate mutase activity Source: UniProtKB-EC
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. chorismate metabolic process Source: InterPro
  2. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:HI_1290
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377T-proteinPRO_0000119197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1290.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi103 – 1064
Turni107 – 1093
Helixi111 – 12111
Turni122 – 1243
Beta strandi127 – 1304
Helixi135 – 1373
Helixi138 – 1425
Beta strandi146 – 1505
Helixi154 – 1563
Helixi157 – 1648
Helixi165 – 1673
Beta strandi172 – 1765
Helixi182 – 19110
Beta strandi193 – 2019
Beta strandi214 – 2218
Helixi223 – 2253
Helixi227 – 2359
Beta strandi239 – 2424
Helixi245 – 25511
Helixi257 – 27014
Helixi277 – 2826
Helixi286 – 29914
Helixi303 – 3108
Helixi317 – 33519
Helixi339 – 35315
Helixi356 – 37015

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PV7X-ray2.00A/B81-377[»]
ProteinModelPortaliP43902.
SMRiP43902. Positions 92-370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292Chorismate mutasePROSITE-ProRule annotationAdd
BLAST
Domaini101 – 364264Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
KOiK14187.
OMAiQANDSRQ.
OrthoDBiEOG618R0Z.
PhylomeDBiP43902.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43902-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFMEALKDL RSEIDSLDRE LIQLFAKRLE LVSQVGKVKH QHGLPIYAPE
60 70 80 90 100
REIAMLQARR LEAEKAGISA DLIEDVLRRF MRESYANENQ FGFKTINSDI
110 120 130 140 150
HKIVIVGGYG KLGGLFARYL RASGYPISIL DREDWAVAES ILANADVVIV
160 170 180 190 200
SVPINLTLET IERLKPYLTE NMLLADLTSV KREPLAKMLE VHTGAVLGLH
210 220 230 240 250
PMFGADIASM AKQVVVRCDG RFPERYEWLL EQIQIWGAKI YQTNATEHDH
260 270 280 290 300
NMTYIQALRH FSTFANGLHL SKQPINLANL LALSSPIYRL ELAMIGRLFA
310 320 330 340 350
QDAELYADII MDKSENLAVI ETLKQTYDEA LTFFENNDRQ GFIDAFHKVR
360 370
DWFGDYSEQF LKESRQLLQQ ANDLKQG
Length:377
Mass (Da):43,022
Last modified:November 1, 1995 - v1
Checksum:i319722CFDFDE5791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22939.1.
PIRiH64114.
RefSeqiNP_439442.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22939; AAC22939; HI_1290.
GeneIDi950220.
KEGGihin:HI1290.
PATRICi20191263. VBIHaeInf48452_1342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22939.1 .
PIRi H64114.
RefSeqi NP_439442.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PV7 X-ray 2.00 A/B 81-377 [» ]
ProteinModelPortali P43902.
SMRi P43902. Positions 92-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1290.

Protocols and materials databases

DNASUi 950220.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22939 ; AAC22939 ; HI_1290 .
GeneIDi 950220.
KEGGi hin:HI1290.
PATRICi 20191263. VBIHaeInf48452_1342.

Phylogenomic databases

eggNOGi COG0287.
KOi K14187.
OMAi QANDSRQ.
OrthoDBi EOG618R0Z.
PhylomeDBi P43902.

Enzyme and pathway databases

UniPathwayi UPA00120 ; UER00203 .
UPA00122 ; UER00961 .

Miscellaneous databases

EvolutionaryTracei P43902.

Family and domain databases

Gene3Di 1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTi SM00830. CM_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsi TIGR01799. CM_T. 1 hit.
PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiTYRA_HAEIN
AccessioniPrimary (citable) accession number: P43902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3