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Protein

T-protein

Gene

tyrA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway:iL-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathway:iprephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. P-protein (pheA), T-protein (tyrA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.3.1.12. 2529.
UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:HI_1290
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377T-proteinPRO_0000119197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1290.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi103 – 1064Combined sources
Turni107 – 1093Combined sources
Helixi111 – 12111Combined sources
Turni122 – 1243Combined sources
Beta strandi127 – 1304Combined sources
Helixi135 – 1373Combined sources
Helixi138 – 1425Combined sources
Beta strandi146 – 1505Combined sources
Helixi154 – 1563Combined sources
Helixi157 – 1648Combined sources
Helixi165 – 1673Combined sources
Beta strandi172 – 1765Combined sources
Helixi182 – 19110Combined sources
Beta strandi193 – 2019Combined sources
Beta strandi214 – 2218Combined sources
Helixi223 – 2253Combined sources
Helixi227 – 2359Combined sources
Beta strandi239 – 2424Combined sources
Helixi245 – 25511Combined sources
Helixi257 – 27014Combined sources
Helixi277 – 2826Combined sources
Helixi286 – 29914Combined sources
Helixi303 – 3108Combined sources
Helixi317 – 33519Combined sources
Helixi339 – 35315Combined sources
Helixi356 – 37015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PV7X-ray2.00A/B81-377[»]
ProteinModelPortaliP43902.
SMRiP43902. Positions 92-370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292Chorismate mutasePROSITE-ProRule annotationAdd
BLAST
Domaini101 – 364264Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
KOiK14187.
OMAiLEQIQIW.
OrthoDBiEOG618R0Z.
PhylomeDBiP43902.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFMEALKDL RSEIDSLDRE LIQLFAKRLE LVSQVGKVKH QHGLPIYAPE
60 70 80 90 100
REIAMLQARR LEAEKAGISA DLIEDVLRRF MRESYANENQ FGFKTINSDI
110 120 130 140 150
HKIVIVGGYG KLGGLFARYL RASGYPISIL DREDWAVAES ILANADVVIV
160 170 180 190 200
SVPINLTLET IERLKPYLTE NMLLADLTSV KREPLAKMLE VHTGAVLGLH
210 220 230 240 250
PMFGADIASM AKQVVVRCDG RFPERYEWLL EQIQIWGAKI YQTNATEHDH
260 270 280 290 300
NMTYIQALRH FSTFANGLHL SKQPINLANL LALSSPIYRL ELAMIGRLFA
310 320 330 340 350
QDAELYADII MDKSENLAVI ETLKQTYDEA LTFFENNDRQ GFIDAFHKVR
360 370
DWFGDYSEQF LKESRQLLQQ ANDLKQG
Length:377
Mass (Da):43,022
Last modified:November 1, 1995 - v1
Checksum:i319722CFDFDE5791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22939.1.
PIRiH64114.
RefSeqiNP_439442.1. NC_000907.1.
WP_005694532.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22939; AAC22939; HI_1290.
GeneIDi950220.
KEGGihin:HI1290.
PATRICi20191263. VBIHaeInf48452_1342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22939.1.
PIRiH64114.
RefSeqiNP_439442.1. NC_000907.1.
WP_005694532.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PV7X-ray2.00A/B81-377[»]
ProteinModelPortaliP43902.
SMRiP43902. Positions 92-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1290.

Protocols and materials databases

DNASUi950220.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22939; AAC22939; HI_1290.
GeneIDi950220.
KEGGihin:HI1290.
PATRICi20191263. VBIHaeInf48452_1342.

Phylogenomic databases

eggNOGiCOG0287.
KOiK14187.
OMAiLEQIQIW.
OrthoDBiEOG618R0Z.
PhylomeDBiP43902.

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.
BRENDAi1.3.1.12. 2529.

Miscellaneous databases

EvolutionaryTraceiP43902.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiTYRA_HAEIN
AccessioniPrimary (citable) accession number: P43902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.