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P43901 (TYRA_LACLM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:llmg_1927
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Prephenate dehydrogenase
PRO_0000119194

Regions

Domain2 – 283282Prephenate/arogenate dehydrogenase
Domain287 – 35468ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
P43901 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 95BA5322AD509482

FASTA35439,531
        10         20         30         40         50         60 
MKKILIIGLG LIGSSIALGI KKAHPEFEIL GSDREEVENI AQKRGIIDSK VELVKGAQEA 

        70         80         90        100        110        120 
DIIILAVPIS VTLELLKQIA TFDLKDGLLI TDAGSTKSEI VELANQLFSG TKVKFIGGHP 

       130        140        150        160        170        180 
MAGSHKSGVM AADLNLFENA YYVLTEESQE LRELLKGLHA KFIILDAKEH DKVTGQVSHF 

       190        200        210        220        230        240 
PHILASTLVW QSDDYAKEHP LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITLERIE 

       250        260        270        280        290        300 
NFKKHLDEIA LKITKRDSQA IEHFFEEGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL 

       310        320        330        340        350 
RVLALLQDFS ITNIKINEEN REDIHGQLQI SFKRAEDLQE AREIIEKATD FTVV 

« Hide

References

« Hide 'large scale' references
[1]"Genetic aspects of aromatic amino acid biosynthesis in Lactococcus lactis."
Griffin H.G., Gasson M.J.
Mol. Gen. Genet. 246:119-127(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MG1363 / F15876.
[2]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MG1363.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78413 Genomic DNA. Translation: CAA55179.1.
AM406671 Genomic DNA. Translation: CAL98496.1.
PIRS52579.
RefSeqYP_001033192.1. NC_009004.1.

3D structure databases

ProteinModelPortalP43901.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING416870.llmg_1927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL98496; CAL98496; llmg_1927.
GeneID4799070.
KEGGllm:llmg_1927.
PATRIC22285043. VBILacLac4574_1974.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043494.
KOK04517.
OMAQRAIRWG.
OrthoDBEOG6B8XMB.
ProtClustDBPRK06545.

Enzyme and pathway databases

BioCycLLAC416870:GCDT-1931-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_LACLM
AccessionPrimary (citable) accession number: P43901
Secondary accession number(s): A2RMG6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways