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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 33NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:llmg_1927
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000000364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191941 – 354Prephenate dehydrogenaseAdd BLAST354

Proteomic databases

PRIDEiP43901

Interactioni

Protein-protein interaction databases

STRINGi416870.llmg_1927

Structurei

3D structure databases

ProteinModelPortaliP43901
SMRiP43901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 283Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST282
Domaini287 – 354ACTPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EVN Bacteria
COG0287 LUCA
HOGENOMiHOG000043494
KOiK04517
OMAiMWRDICL

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR002912 ACT_dom
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
PfamiView protein in Pfam
PF02153 PDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51176 PDH_ADH, 1 hit

Sequencei

Sequence statusi: Complete.

P43901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILIIGLG LIGSSIALGI KKAHPEFEIL GSDREEVENI AQKRGIIDSK
60 70 80 90 100
VELVKGAQEA DIIILAVPIS VTLELLKQIA TFDLKDGLLI TDAGSTKSEI
110 120 130 140 150
VELANQLFSG TKVKFIGGHP MAGSHKSGVM AADLNLFENA YYVLTEESQE
160 170 180 190 200
LRELLKGLHA KFIILDAKEH DKVTGQVSHF PHILASTLVW QSDDYAKEHP
210 220 230 240 250
LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITLERIE NFKKHLDEIA
260 270 280 290 300
LKITKRDSQA IEHFFEEGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL
310 320 330 340 350
RVLALLQDFS ITNIKINEEN REDIHGQLQI SFKRAEDLQE AREIIEKATD

FTVV
Length:354
Mass (Da):39,531
Last modified:November 1, 1995 - v1
Checksum:i95BA5322AD509482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78413 Genomic DNA Translation: CAA55179.1
AM406671 Genomic DNA Translation: CAL98496.1
PIRiS52579
RefSeqiWP_011835675.1, NC_009004.1

Genome annotation databases

EnsemblBacteriaiCAL98496; CAL98496; llmg_1927
KEGGillm:llmg_1927

Similar proteinsi

Entry informationi

Entry nameiTYRA_LACLM
AccessioniPrimary (citable) accession number: P43901
Secondary accession number(s): A2RMG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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