Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P43901 (TYRA_LACLM)

Last modified November 3, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12
Gene names
Name: tyrA
Ordered Locus Names: llmg_1927
OrganismLactococcus lactis subsp. cremoris (strain MG1363) [Complete proteome] [HAMAP]
Taxonomic identifier416870 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Prephenate dehydrogenase
PRO_0000119194

Regions

Domain2 – 283282Prephenate/arogenate dehydrogenase
Domain286 – 35469ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
P43901-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 95BA5322AD509482

FASTA35439,531
        10         20         30         40         50         60 
MKKILIIGLG LIGSSIALGI KKAHPEFEIL GSDREEVENI AQKRGIIDSK VELVKGAQEA 

        70         80         90        100        110        120 
DIIILAVPIS VTLELLKQIA TFDLKDGLLI TDAGSTKSEI VELANQLFSG TKVKFIGGHP 

       130        140        150        160        170        180 
MAGSHKSGVM AADLNLFENA YYVLTEESQE LRELLKGLHA KFIILDAKEH DKVTGQVSHF 

       190        200        210        220        230        240 
PHILASTLVW QSDDYAKEHP LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITLERIE 

       250        260        270        280        290        300 
NFKKHLDEIA LKITKRDSQA IEHFFEEGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL 

       310        320        330        340        350 
RVLALLQDFS ITNIKINEEN REDIHGQLQI SFKRAEDLQE AREIIEKATD FTVV 

« Hide

References

« Hide 'large scale' references
[1]"Genetic aspects of aromatic amino acid biosynthesis in Lactococcus lactis."
Griffin H.G., Gasson M.J.
Mol. Gen. Genet. 246:119-127(1995) [PubMed: 7823907] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MG1363 / F15876.
[2]"The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
J. Bacteriol. 189:3256-3270(2007) [PubMed: 17307855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

X78413 Genomic DNA. Translation: CAA55179.1.
AM406671 Genomic DNA. Translation: CAL98496.1.
PIRS52579.
RefSeqYP_001033192.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP43901.

Genome annotation databases

GeneID4799070.
GenomeReviewsGene locus llmg_1927 in contig AM406671_GR.
KEGGllm:llmg_1927.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQRAIRWG.

Family and domain databases

InterProIPR002912. ACT_bd.
IPR003099. Prephen_DH.
[Graphical view]
PANTHERPTHR21363. Prephen_DH. 1 hit.
PfamPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PROSITEPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_LACLM
AccessionPrimary (citable) accession number: P43901
Secondary accession number(s): A2RMG6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents