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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-1931-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:llmg_1927
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Prephenate dehydrogenasePRO_0000119194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416870.llmg_1927.

Structurei

3D structure databases

ProteinModelPortaliP43901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 283282Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST
Domaini287 – 35468ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILIIGLG LIGSSIALGI KKAHPEFEIL GSDREEVENI AQKRGIIDSK
60 70 80 90 100
VELVKGAQEA DIIILAVPIS VTLELLKQIA TFDLKDGLLI TDAGSTKSEI
110 120 130 140 150
VELANQLFSG TKVKFIGGHP MAGSHKSGVM AADLNLFENA YYVLTEESQE
160 170 180 190 200
LRELLKGLHA KFIILDAKEH DKVTGQVSHF PHILASTLVW QSDDYAKEHP
210 220 230 240 250
LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITLERIE NFKKHLDEIA
260 270 280 290 300
LKITKRDSQA IEHFFEEGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL
310 320 330 340 350
RVLALLQDFS ITNIKINEEN REDIHGQLQI SFKRAEDLQE AREIIEKATD

FTVV
Length:354
Mass (Da):39,531
Last modified:November 1, 1995 - v1
Checksum:i95BA5322AD509482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78413 Genomic DNA. Translation: CAA55179.1.
AM406671 Genomic DNA. Translation: CAL98496.1.
PIRiS52579.
RefSeqiWP_011835675.1. NC_009004.1.
YP_001033192.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL98496; CAL98496; llmg_1927.
KEGGillm:llmg_1927.
PATRICi22285043. VBILacLac4574_1974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78413 Genomic DNA. Translation: CAA55179.1.
AM406671 Genomic DNA. Translation: CAL98496.1.
PIRiS52579.
RefSeqiWP_011835675.1. NC_009004.1.
YP_001033192.1. NC_009004.1.

3D structure databases

ProteinModelPortaliP43901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416870.llmg_1927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL98496; CAL98496; llmg_1927.
KEGGillm:llmg_1927.
PATRICi22285043. VBILacLac4574_1974.

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiMWRDICL.
OrthoDBiEOG6B8XMB.

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961.
BioCyciLLAC416870:GCDT-1931-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic aspects of aromatic amino acid biosynthesis in Lactococcus lactis."
    Griffin H.G., Gasson M.J.
    Mol. Gen. Genet. 246:119-127(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MG1363 / F15876.
  2. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
    Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
    J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MG1363.

Entry informationi

Entry nameiTYRA_LACLM
AccessioniPrimary (citable) accession number: P43901
Secondary accession number(s): A2RMG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.