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Protein

Elongation factor Ts, mitochondrial

Gene

TSFM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-5389840. Mitochondrial translation elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Ts, mitochondrialUniRule annotation
Short name:
EF-TsUniRule annotation
Short name:
EF-TsMtUniRule annotation
Gene namesi
Name:TSFMUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionAdd BLAST55
ChainiPRO_000000746756 – 338Elongation factor Ts, mitochondrialAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89N6-succinyllysineBy similarity1
Modified residuei146N6-succinyllysineBy similarity1
Modified residuei205N6-succinyllysineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43896.
PRIDEiP43896.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016912.

Interactioni

Protein-protein interaction databases

IntActiP43896. 1 interactor.
STRINGi9913.ENSBTAP00000022496.

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 70Combined sources14
Helixi74 – 83Combined sources10
Turni84 – 86Combined sources3
Helixi88 – 110Combined sources23
Beta strandi117 – 125Combined sources9
Beta strandi128 – 137Combined sources10
Helixi139 – 142Combined sources4
Helixi145 – 162Combined sources18
Beta strandi169 – 171Combined sources3
Beta strandi173 – 177Combined sources5
Helixi179 – 183Combined sources5
Beta strandi189 – 191Combined sources3
Helixi195 – 206Combined sources12
Beta strandi210 – 219Combined sources10
Beta strandi224 – 232Combined sources9
Beta strandi243 – 254Combined sources12
Helixi259 – 261Combined sources3
Helixi263 – 276Combined sources14
Helixi290 – 292Combined sources3
Helixi296 – 298Combined sources3
Helixi309 – 313Combined sources5
Helixi314 – 316Combined sources3
Beta strandi319 – 327Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB2X-ray2.20B56-338[»]
ProteinModelPortaliP43896.
SMRiP43896.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43896.

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1071. Eukaryota.
COG0264. LUCA.
GeneTreeiENSGT00390000016293.
HOGENOMiHOG000220988.
HOVERGENiHBG005571.
InParanoidiP43896.
KOiK02357.
OMAiLVICETS.
OrthoDBiEOG091G0E11.
TreeFamiTF314154.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRSLRLC LVARTGSCPL SALGPGPLLP SLQAGLPLLQ SPQQWHTFHS
60 70 80 90 100
GSWLSSASSK ELLMKLRRKT GYSFINCKKA LETCGGDLKQ AESWLHKQAQ
110 120 130 140 150
KEGWSKAARL HGRKTKEGLI GLLQEGDTTV LVEVNCETDF VSRNLKFQQL
160 170 180 190 200
VQQVALGTLL HCQNLKDQLS TYSKGFLNSS ELSELPAGPE REGSLKDQLA
210 220 230 240 250
LAIGKLGENM ILKRAAWVKV PAGFYVGSYV HGAMHSPSLH NLVLGKYGAL
260 270 280 290 300
VICETSELKA NLADLGRRLG QHVVGMAPLS VGSLDDEPGG EAETKMLSQP
310 320 330
YLLDPSITLG QYVQPHGVSV VDFVRFECGE GEDAADAE
Length:338
Mass (Da):36,602
Last modified:November 1, 1995 - v1
Checksum:i449236159482DD68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37935 mRNA. Translation: AAA96807.1.
BC149988 mRNA. Translation: AAI49989.1.
PIRiI45941.
RefSeqiNP_776629.1. NM_174204.3.
UniGeneiBt.103027.

Genome annotation databases

EnsembliENSBTAT00000022496; ENSBTAP00000022496; ENSBTAG00000016912.
GeneIDi281551.
KEGGibta:281551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37935 mRNA. Translation: AAA96807.1.
BC149988 mRNA. Translation: AAI49989.1.
PIRiI45941.
RefSeqiNP_776629.1. NM_174204.3.
UniGeneiBt.103027.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB2X-ray2.20B56-338[»]
ProteinModelPortaliP43896.
SMRiP43896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP43896. 1 interactor.
STRINGi9913.ENSBTAP00000022496.

Proteomic databases

PaxDbiP43896.
PRIDEiP43896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022496; ENSBTAP00000022496; ENSBTAG00000016912.
GeneIDi281551.
KEGGibta:281551.

Organism-specific databases

CTDi10102.

Phylogenomic databases

eggNOGiKOG1071. Eukaryota.
COG0264. LUCA.
GeneTreeiENSGT00390000016293.
HOGENOMiHOG000220988.
HOVERGENiHBG005571.
InParanoidiP43896.
KOiK02357.
OMAiLVICETS.
OrthoDBiEOG091G0E11.
TreeFamiTF314154.

Enzyme and pathway databases

ReactomeiR-BTA-5389840. Mitochondrial translation elongation.

Miscellaneous databases

EvolutionaryTraceiP43896.

Gene expression databases

BgeeiENSBTAG00000016912.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFTS_BOVIN
AccessioniPrimary (citable) accession number: P43896
Secondary accession number(s): A6QQT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.