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Protein

Elongation factor Ts, mitochondrial

Gene

TSFM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Ts, mitochondrialUniRule annotation
Short name:
EF-TsUniRule annotation
Short name:
EF-TsMtUniRule annotation
Gene namesi
Name:TSFMUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:36413 TSFM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionAdd BLAST55
ChainiPRO_000000746756 – 338Elongation factor Ts, mitochondrialAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89N6-succinyllysineBy similarity1
Modified residuei146N6-succinyllysineBy similarity1
Modified residuei205N6-succinyllysineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43896
PRIDEiP43896

Expressioni

Gene expression databases

BgeeiENSBTAG00000016912

Interactioni

Protein-protein interaction databases

IntActiP43896, 1 interactor
STRINGi9913.ENSBTAP00000022496

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 70Combined sources14
Helixi74 – 83Combined sources10
Turni84 – 86Combined sources3
Helixi88 – 110Combined sources23
Beta strandi117 – 125Combined sources9
Beta strandi128 – 137Combined sources10
Helixi139 – 142Combined sources4
Helixi145 – 162Combined sources18
Beta strandi169 – 171Combined sources3
Beta strandi173 – 177Combined sources5
Helixi179 – 183Combined sources5
Beta strandi189 – 191Combined sources3
Helixi195 – 206Combined sources12
Beta strandi210 – 219Combined sources10
Beta strandi224 – 232Combined sources9
Beta strandi243 – 254Combined sources12
Helixi259 – 261Combined sources3
Helixi263 – 276Combined sources14
Helixi290 – 292Combined sources3
Helixi296 – 298Combined sources3
Helixi309 – 313Combined sources5
Helixi314 – 316Combined sources3
Beta strandi319 – 327Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB2X-ray2.20B56-338[»]
ProteinModelPortaliP43896
SMRiP43896
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43896

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1071 Eukaryota
COG0264 LUCA
GeneTreeiENSGT00390000016293
HOGENOMiHOG000220988
HOVERGENiHBG005571
InParanoidiP43896
KOiK02357
OMAiGYTFANC
OrthoDBiEOG091G0E11
TreeFamiTF314154

Family and domain databases

Gene3Di3.30.479.20, 4 hits
HAMAPiMF_00050 EF_Ts, 1 hit
InterProiView protein in InterPro
IPR036402 EF-Ts_dimer_sf
IPR001816 Transl_elong_EFTs/EF1B
IPR014039 Transl_elong_EFTs/EF1B_dimer
IPR018101 Transl_elong_Ts_CS
IPR009060 UBA-like_sf
PANTHERiPTHR11741 PTHR11741, 1 hit
PfamiView protein in Pfam
PF00889 EF_TS, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54713 SSF54713, 2 hits
PROSITEiView protein in PROSITE
PS01126 EF_TS_1, 1 hit
PS01127 EF_TS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRSLRLC LVARTGSCPL SALGPGPLLP SLQAGLPLLQ SPQQWHTFHS
60 70 80 90 100
GSWLSSASSK ELLMKLRRKT GYSFINCKKA LETCGGDLKQ AESWLHKQAQ
110 120 130 140 150
KEGWSKAARL HGRKTKEGLI GLLQEGDTTV LVEVNCETDF VSRNLKFQQL
160 170 180 190 200
VQQVALGTLL HCQNLKDQLS TYSKGFLNSS ELSELPAGPE REGSLKDQLA
210 220 230 240 250
LAIGKLGENM ILKRAAWVKV PAGFYVGSYV HGAMHSPSLH NLVLGKYGAL
260 270 280 290 300
VICETSELKA NLADLGRRLG QHVVGMAPLS VGSLDDEPGG EAETKMLSQP
310 320 330
YLLDPSITLG QYVQPHGVSV VDFVRFECGE GEDAADAE
Length:338
Mass (Da):36,602
Last modified:November 1, 1995 - v1
Checksum:i449236159482DD68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37935 mRNA Translation: AAA96807.1
BC149988 mRNA Translation: AAI49989.1
PIRiI45941
RefSeqiNP_776629.1, NM_174204.3
UniGeneiBt.103027

Genome annotation databases

EnsembliENSBTAT00000022496; ENSBTAP00000022496; ENSBTAG00000016912
GeneIDi281551
KEGGibta:281551

Similar proteinsi

Entry informationi

Entry nameiEFTS_BOVIN
AccessioniPrimary (citable) accession number: P43896
Secondary accession number(s): A6QQT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health