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Protein

Elongation factor Ts

Gene

tsf

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Ts
Short name:
EF-Ts
Gene namesi
Name:tsf
Ordered Locus Names:TTHA0860
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001612221 – 196Elongation factor TsAdd BLAST196

Interactioni

Subunit structurei

Heterotetramer composed of two EF-Ts.EF-Tu dimer complexes.

Protein-protein interaction databases

DIPiDIP-6078N.
IntActiP43895. 1 interactor.
STRINGi300852.TTHA0860.

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 14Combined sources12
Helixi18 – 27Combined sources10
Turni28 – 30Combined sources3
Helixi32 – 50Combined sources19
Beta strandi57 – 64Combined sources8
Beta strandi68 – 79Combined sources12
Helixi81 – 85Combined sources5
Helixi87 – 103Combined sources17
Beta strandi106 – 109Combined sources4
Helixi110 – 112Combined sources3
Helixi115 – 130Combined sources16
Turni131 – 133Combined sources3
Helixi136 – 154Combined sources19
Helixi156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi164 – 168Combined sources5
Helixi169 – 180Combined sources12
Beta strandi185 – 193Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIPX-ray3.00C/D/G/H1-196[»]
1TFEX-ray1.70A55-196[»]
ProteinModelPortaliP43895.
SMRiP43895.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43895.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 83Involved in Mg(2+) ion dislocation from EF-TuBy similarity4

Sequence similaritiesi

Belongs to the EF-Ts family.Curated

Phylogenomic databases

eggNOGiENOG4105CU7. Bacteria.
COG0264. LUCA.
HOGENOMiHOG000220986.
KOiK02357.
OMAiQIYIQAA.
PhylomeDBiP43895.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 1 hit.
TIGRFAMsiTIGR00116. tsf. 1 hit.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQMELIKKL REATGAGMMD VKRALEDAGW DEEKAVQLLR ERGAMKAAKK
60 70 80 90 100
ADREAREGII GHYIHHNQRV GVLVELNCET DFVARNELFQ NLAKDLAMHI
110 120 130 140 150
AMMNPRYVSA EEIPAEELEK ERQIYIQAAL NEGKPQQIAE KIAEGRLKKY
160 170 180 190
LEEVVLLEQP FVKDDKVKVK ELIQQAIAKI GENIVVRRFC RFELGA
Length:196
Mass (Da):22,413
Last modified:November 1, 1995 - v1
Checksum:i36A771F686BBB0DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83598 Genomic DNA. Translation: CAA58578.1.
AP008226 Genomic DNA. Translation: BAD70683.1.
RefSeqiWP_011228249.1. NC_006461.1.
YP_144126.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70683; BAD70683; BAD70683.
GeneIDi3170120.
KEGGittj:TTHA0860.
PATRICi23956702. VBITheThe93045_0854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83598 Genomic DNA. Translation: CAA58578.1.
AP008226 Genomic DNA. Translation: BAD70683.1.
RefSeqiWP_011228249.1. NC_006461.1.
YP_144126.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIPX-ray3.00C/D/G/H1-196[»]
1TFEX-ray1.70A55-196[»]
ProteinModelPortaliP43895.
SMRiP43895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6078N.
IntActiP43895. 1 interactor.
STRINGi300852.TTHA0860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70683; BAD70683; BAD70683.
GeneIDi3170120.
KEGGittj:TTHA0860.
PATRICi23956702. VBITheThe93045_0854.

Phylogenomic databases

eggNOGiENOG4105CU7. Bacteria.
COG0264. LUCA.
HOGENOMiHOG000220986.
KOiK02357.
OMAiQIYIQAA.
PhylomeDBiP43895.

Miscellaneous databases

EvolutionaryTraceiP43895.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 1 hit.
TIGRFAMsiTIGR00116. tsf. 1 hit.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFTS_THET8
AccessioniPrimary (citable) accession number: P43895
Secondary accession number(s): Q5SJZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.