P43893 (KCY2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase 2
Short name=CK 2
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase 2
Short name=CMP kinase 2

Gene names

Name:	cmk2
Synonyms:	cmkB
Ordered Locus Names:	HI_1646

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.
Sequence caution	The sequence AAC23293.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Cytidylate kinase 2 HAMAP MF_00238		PRO_0000131922
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43893 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1F9B12FE434D16F0	FASTA	222	24,368
	10 20 30 40 50 60 MIITVDGPSG AGKGTLCYAL AEKLGYALLD SGAIYRVTAL AALQRKTDLT NETDLAELAR 70 80 90 100 110 120 HLDIQFIPQN GEVNIFLAGM DVSRLIRTQE VADAASKVAV FQKVRSALLQ LQQDFAKNDG 130 140 150 160 170 180 LIADGRDMGT VVFPNAQVKL FLDASAEERA KRRYKQLQNK GINGNFAQIL AEIKERDFRD 190 200 210 220 RNREVAPLKP ADDAFYYSLN SSIISCAFFT ISSEPTNSGT RS

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23293.1. Different initiation.
PIR	H64134.
RefSeq	NP_439788.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43893.
SMR	P43893. Positions 2-205.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950485.
GenomeReviews	Gene locus HI_1646 in contig L42023_GR.
NMPDR	fig|71421.1.peg.1560.
PATRIC	20192037. VBIHaeInf48452_1722.
TIGR	HI_1646.
Phylogenomic databases
HOGENOM	HBG354377.
OMA	FFTISSE.
PhylomeDB	P43893.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1646-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY2_HAEIN

Accession

Primary (citable) accession number: P43893

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program