Reviewed, UniProtKB/Swiss-Prot P43892 (KCY1_HAEIN)

Names and origin

Protein names

Recommended name:
    Cytidylate kinase 1
      Short name=CK 1
    EC=2.7.4.14
Alternative name(s):
    Cytidine monophosphate kinase 1
      Short name=CMP kinase 1

Gene names

Name:	cmk1
Synonyms:	cmkA
Ordered Locus Names:	HI1219

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Cytidylate kinase 1 HAMAP MF_00238		PRO_0000131921
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43892-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 3DD5694F323C98D3	FASTA	231	25,500
	10 20 30 40 50 60 MIITVDGPSG AGKGTLCYAL AEKLGYALLD SGAIYRVTAL AALQRKTDLT NETDLAELAR 70 80 90 100 110 120 HLDIQFIPQN GEVSILLAGM DVSRLIRTQE VADAASKVAV FQKVRSALLQ LQQDFAKNDG 130 140 150 160 170 180 LIADGRDMGT VVFPNAQVKL FLDASAEERA KRRYKQLQNK GINGNFAQIL AEIKERDFRD 190 200 210 220 230 RNREVAPLKP ADDALLLDST TLSIDEVIDQ ALAYIQRXGI SFRFNCLFKE E

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC22872.1.
PIR	I64110.
RefSeq	NP_439375.2.
3D structure databases
HSSP	HSSP built from PDB template 1KDO based on UniProtKB P23863.
ModBase	Search...
Genome annotation databases
GeneID	950461.
GenomeReviews	Gene locus HI1219 in contig L42023_GR.
KEGG	hin:HI1219.
NMPDR	fig|71421.1.peg.1165.
TIGR	HI1219.
Phylogenomic databases
HOGENOM	P43892.
OMA	GLLYRAV.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1219-MON.
BRENDA	2.7.4.14. 109.
Family and domain databases
HAMAP	MF_00238. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kin_d. [Graphical view]
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY1_HAEIN

Accession

Primary (citable) accession number: P43892

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)