P43886 (CYSE_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine acetyltransferase
Short name=SAT
EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	HI_0606

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 267

267

Serine acetyltransferase

PRO_0000068674

Secondary structure

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267

Helix Strand Turn

Details...

Helix

2 – 19

18

Helix

21 – 23

3

Helix

24 – 30

7

Turn

31 – 33

3

Helix

37 – 49

13

Beta strand

52 – 54

3

Helix

56 – 69

14

Helix

72 – 87

16

Helix

95 – 100

6

Helix

102 – 117

16

Turn

118 – 120

3

Helix

122 – 136

15

Beta strand

137 – 140

4

Beta strand

151 – 154

4

Beta strand

158 – 160

3

Beta strand

171 – 173

3

Beta strand

177 – 179

3

Beta strand

185 – 187

3

Beta strand

203 – 207

5

Beta strand

231 – 233

3

Turn

234 – 237

4

Helix

248 – 251

4

Sequences

	Sequence		Length	Mass (Da)
	P43886 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 93428DE9D504DFB4	FASTA	267	29,166
	10 20 30 40 50 60 MTLDVWQHIR QEAKELAENE PMLASFFHST ILKHQNLGGA LSYLLANKLA NPIMPAISLR 70 80 90 100 110 120 EIIEEAYQSN PSIIDCAACD IQAVRHRDPA VELWSTPLLY LKGFHAIQSY RITHYLWNQN 130 140 150 160 170 180 RKSLALYLQN QISVAFDVDI HPAAKIGHGI MFDHATGIVV GETSVIENDV SILQGVTLGG 190 200 210 220 230 240 TGKESGDRHP KVREGVMIGA GAKILGNIEV GKYAKIGANS VVLNPVPEYA TAAGVPARIV 250 260 SQDKAAKPAF DMNQYFIGID DGMNLNI

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

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Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L42023 Genomic DNA. Translation: AAC22265.1.

PIR

G64080.

RefSeq

NP_438764.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1S80	X-ray	2.70	A/B/C/D/E/F	2-266	[»]
1SSM	X-ray	2.15	A/B/C/D/E/F	1-242	[»]
1SSQ	X-ray	1.85	A/D	3-267	[»]
1SST	X-ray	2.00	A/B/C	1-267	[»]
1Y7L	X-ray	1.55	P	258-267	[»]

ProteinModelPortal

P43886.

SMR

P43886. Positions 1-240.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

949654.

GenomeReviews

Gene locus HI_0606 in contig L42023_GR.

KEGG

hin:HI0606.

PATRIC

20189791. VBIHaeInf48452_0630.

TIGR

HI_0606.

Phylogenomic databases

HOGENOM

HBG754554.

OMA

DPLLYFK.

ProtClustDB

PRK11132.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0606-MONOMER.

Family and domain databases

InterPro

IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010493. Ser_AcTrfase_N.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]

KO

K00640.

Pfam

PF00132. Hexapep. 1 hit.
PF06426. SATase_N. 1 hit.
[Graphical view]

SMART

SM00971. SATase_N. 1 hit.
[Graphical view]

SUPFAM

SSF51161. Trimer_LpxA_like. 1 hit.

TIGRFAMs

TIGR01172. CysE. 1 hit.

PROSITE

PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CYSE_HAEIN

Accession

Primary (citable) accession number: P43886

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program