Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine acetyltransferase

Gene

cysE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase (cysE)
  2. Cysteine synthase (cysK)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Enzyme and pathway databases

BRENDAi2.3.1.30. 2529.
SABIO-RKP43886.
UniPathwayiUPA00136; UER00199.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine acetyltransferase (EC:2.3.1.30)
Short name:
SAT
Gene namesi
Name:cysE
Ordered Locus Names:HI_0606
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Serine acetyltransferasePRO_0000068674Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0606.

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1917Combined sources
Helixi21 – 3010Combined sources
Turni31 – 333Combined sources
Beta strandi34 – 363Combined sources
Helixi37 – 4913Combined sources
Beta strandi52 – 543Combined sources
Helixi56 – 6914Combined sources
Helixi72 – 8716Combined sources
Helixi95 – 1006Combined sources
Helixi102 – 11716Combined sources
Turni118 – 1203Combined sources
Helixi122 – 13615Combined sources
Beta strandi137 – 1404Combined sources
Beta strandi151 – 1544Combined sources
Beta strandi158 – 1603Combined sources
Beta strandi171 – 1733Combined sources
Beta strandi177 – 1793Combined sources
Beta strandi182 – 1843Combined sources
Beta strandi185 – 1873Combined sources
Beta strandi203 – 2075Combined sources
Beta strandi231 – 2333Combined sources
Turni234 – 2374Combined sources
Beta strandi238 – 2403Combined sources
Helixi248 – 2514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S80X-ray2.70A/B/C/D/E/F2-266[»]
1SSMX-ray2.15A/B/C/D/E/F1-242[»]
1SSQX-ray1.85A/D1-267[»]
1SSTX-ray2.00A/B/C1-267[»]
1Y7LX-ray1.55P258-267[»]
ProteinModelPortaliP43886.
SMRiP43886. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43886.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7W. Bacteria.
COG1045. LUCA.
KOiK00640.
OMAiFHALQSY.
PhylomeDBiP43886.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR010493. Ser_AcTrfase_N.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF06426. SATase_N. 1 hit.
[Graphical view]
SMARTiSM00971. SATase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01172. cysE. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDVWQHIR QEAKELAENE PMLASFFHST ILKHQNLGGA LSYLLANKLA
60 70 80 90 100
NPIMPAISLR EIIEEAYQSN PSIIDCAACD IQAVRHRDPA VELWSTPLLY
110 120 130 140 150
LKGFHAIQSY RITHYLWNQN RKSLALYLQN QISVAFDVDI HPAAKIGHGI
160 170 180 190 200
MFDHATGIVV GETSVIENDV SILQGVTLGG TGKESGDRHP KVREGVMIGA
210 220 230 240 250
GAKILGNIEV GKYAKIGANS VVLNPVPEYA TAAGVPARIV SQDKAAKPAF
260
DMNQYFIGID DGMNLNI
Length:267
Mass (Da):29,166
Last modified:November 1, 1995 - v1
Checksum:i93428DE9D504DFB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22265.1.
PIRiG64080.
RefSeqiNP_438764.1. NC_000907.1.
WP_005694542.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22265; AAC22265; HI_0606.
GeneIDi949654.
KEGGihin:HI0606.
PATRICi20189791. VBIHaeInf48452_0630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22265.1.
PIRiG64080.
RefSeqiNP_438764.1. NC_000907.1.
WP_005694542.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S80X-ray2.70A/B/C/D/E/F2-266[»]
1SSMX-ray2.15A/B/C/D/E/F1-242[»]
1SSQX-ray1.85A/D1-267[»]
1SSTX-ray2.00A/B/C1-267[»]
1Y7LX-ray1.55P258-267[»]
ProteinModelPortaliP43886.
SMRiP43886. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0606.

Protocols and materials databases

DNASUi949654.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22265; AAC22265; HI_0606.
GeneIDi949654.
KEGGihin:HI0606.
PATRICi20189791. VBIHaeInf48452_0630.

Phylogenomic databases

eggNOGiENOG4105D7W. Bacteria.
COG1045. LUCA.
KOiK00640.
OMAiFHALQSY.
PhylomeDBiP43886.

Enzyme and pathway databases

UniPathwayiUPA00136; UER00199.
BRENDAi2.3.1.30. 2529.
SABIO-RKP43886.

Miscellaneous databases

EvolutionaryTraceiP43886.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR010493. Ser_AcTrfase_N.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF06426. SATase_N. 1 hit.
[Graphical view]
SMARTiSM00971. SATase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01172. cysE. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSE_HAEIN
AccessioniPrimary (citable) accession number: P43886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.