Reviewed, UniProtKB/Swiss-Prot P43885 (SERA_HAEIN)

Names and origin

Protein names

Recommended name:
    D-3-phosphoglycerate dehydrogenase
      Short name=PGDH
    EC=1.1.1.95

Gene names

Name:	serA
Ordered Locus Names:	HI0465

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH.
Enzyme regulation	In bacteria displays feedback inhibition by L-serine By similarity.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glyceric acid: step 1/3.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Gram-negative-bacterium-type cell wall Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro phosphoglycerate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	D-3-phosphoglycerate dehydrogenase		PRO_0000076002
Regions
	Domain	340 – 409	70	ACT
Sites
	Active site	241	1	By similarity
	Active site	270	1	By similarity
	Active site	293	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43885-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: C5A75E6D685B7C80	FASTA	410	44,665
	10 20 30 40 50 60 MTNKVSLDKS KIKFVLFEGV HQSALDTLHA AGYTNIDYYK KALDGDELKE AIKDVHFIGL 70 80 90 100 110 120 RSRTHLTAEM IEAAPKLIAV GCFCIGTNQV DLNAAKARGI PVFNAPFSNT RSVAELVLGE 130 140 150 160 170 180 ILLLMRNVPQ ANAEVHRGVW NKSATGSHEV RGKKLGIIGY GHIGSQLSII AESLGMDVYF 190 200 210 220 230 240 YDIENKLPLG NAKQVRSLEE LLSSCDVVSL HVPELPSTKN LMNVARIAQL KQGAILINAA 250 260 270 280 290 300 RGTVVDIDAL AQALKDGKLQ GAAIDVFPVE PASINEEFIS PLREFDNVIL TPHIGGSTAE 310 320 330 340 350 360 AQENIGFEVA GKFVKYSDNG STLSSVNFPE VSLPEHEGTK RLLHIHENRP GILNKLNQIF 370 380 390 400 410 VEANLNIAAQ YLQTDPKIGY VVVDVETNDA SPLLTKLKEI DGTIRARVLY

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC22124.1.
PIR	C64070.
RefSeq	NP_438626.1.
3D structure databases
HSSP	HSSP built from PDB template 1PSD based on UniProtKB P08328.
ModBase	Search...
Genome annotation databases
GeneID	950636.
GenomeReviews	Gene locus HI0465 in contig L42023_GR.
KEGG	hin:HI0465.
NMPDR	fig|71421.1.peg.439.
TIGR	HI0465.
Phylogenomic databases
HOGENOM	P43885.
OMA	P43885. GIRSKTK.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0465-MON.
BRENDA	1.1.1.95. 109.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR010771. IgaA. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERA_HAEIN

Accession

Primary (citable) accession number: P43885

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)