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Protein

Perilipin-1

Gene

Plin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processLipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-163560. Triglyceride catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-1
Alternative name(s):
Lipid droplet-associated protein
Gene namesi
Name:Plin1
Synonyms:Peri, Plin
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3351. Plin1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998861 – 517Perilipin-1Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei224PhosphothreonineBy similarity1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei301PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei434PhosphoserineBy similarity1
Modified residuei436PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Isoform B (identifier: P43884-2)
Modified residuei408PhosphoserineCombined sources1

Post-translational modificationi

Major cAMP-dependent protein kinase substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL. When unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43884.
PRIDEiP43884.

PTM databases

iPTMnetiP43884.
PhosphoSitePlusiP43884.

Expressioni

Tissue specificityi

Adipocytes.

Interactioni

Subunit structurei

Interacts with ABHD5. Interacts with CIDEC (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061809.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni291 – 322Required for interaction with CIDECBy similarityAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi308 – 319Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiENOG410IGIT. Eukaryota.
ENOG4111TBF. LUCA.
HOGENOMiHOG000261608.
InParanoidiP43884.

Family and domain databases

InterProiView protein in InterPro
IPR004279. Perilipin.
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiView protein in Pfam
PF03036. Perilipin. 1 hit.
PIRSFiPIRSF036881. PAT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P43884-1) [UniParc]FASTAAdd to basket
Also known as: PERIA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMNKGPTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YNSTKEAHPL
60 70 80 90 100
VASVCNAYEK GVQGASNLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE
110 120 130 140 150
KIPALQYPPE KIASELKGTI STRLRSARNS ISVPIASTSD KVLGATLAGC
160 170 180 190 200
ELALGMAKET AEYAANTRVG RLASGGADLA LGSIEKVVEY LLPPDKVESA
210 220 230 240 250
PSSGRQKTQK APKAKPSLLR RVSTLANTLS RHTMQTTARA LKRGHSLAMW
260 270 280 290 300
IPGVAPLSSL AQWGASAAMQ VVSRRQSEVR VPWLHNLAAS KDENHEDQTD
310 320 330 340 350
TEGEETDEEE EEEESEAEEN VLREVTALPT PLGFLGGVVH TVQKTLQNTI
360 370 380 390 400
SAVTWAPAAV LGTVGRILHL TPAQAVSSTK GRAMSLSDAL KGVTDNVVDT
410 420 430 440 450
VVHYVPLPRL SLMEPESEFQ DIDNPPAEVE RKGSGSRPAS PESTARPGQP
460 470 480 490 500
RAACAVRGLS APSCPDLDDK TETSARPGLL AMPREKPARR VSDSFFRPSV
510
MEPILGRTQY SQLRKKS
Length:517
Mass (Da):55,614
Last modified:November 1, 1995 - v1
Checksum:i1041F76DC2F55A25
GO
Isoform B (identifier: P43884-2) [UniParc]FASTAAdd to basket
Also known as: PERIB

The sequence of this isoform differs from the canonical sequence as follows:
     407-422: LPRLSLMEPESEFQDI → VSPAPGPPSDSQGRFD
     423-517: Missing.

Show »
Length:422
Mass (Da):45,080
Checksum:iB07043C3ABB4758B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004662407 – 422LPRLS…EFQDI → VSPAPGPPSDSQGRFD in isoform B. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_004663423 – 517Missing in isoform B. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26043 mRNA. Translation: AAA41830.1.
L26044 mRNA. Translation: AAA41831.1.
PIRiA49413.
UniGeneiRn.9737.

Genome annotation databases

UCSCiRGD:3351. rat. [P43884-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPLIN1_RAT
AccessioniPrimary (citable) accession number: P43884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families