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P43884

- PLIN1_RAT

UniProt

P43884 - PLIN1_RAT

Protein

Perilipin-1

Gene

Plin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels By similarity.By similarity

    GO - Biological processi

    1. lipid metabolic process Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-1
    Alternative name(s):
    Lipid droplet-associated protein
    Gene namesi
    Name:Plin1
    Synonyms:Peri, Plin
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3351. Plin1.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Lipid droplet
    Note: Lipid droplet surface-associated.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. lipid particle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Lipid droplet

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Perilipin-1PRO_0000099886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei411 – 4111PhosphoserineBy similarity
    Modified residuei460 – 4601PhosphoserineBy similarity

    Post-translational modificationi

    Major cAMP-dependent protein kinase substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL. When unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.1 Publication
    The N-terminus is blocked.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP43884.

    PTM databases

    PhosphoSiteiP43884.

    Expressioni

    Tissue specificityi

    Adipocytes.

    Gene expression databases

    GenevestigatoriP43884.

    Interactioni

    Subunit structurei

    Interacts with ABHD5. Interacts with CIDEC By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020559.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni291 – 32232Required for interaction with CIDECBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi308 – 31912Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Phylogenomic databases

    eggNOGiNOG75006.
    HOGENOMiHOG000261608.
    InParanoidiP43884.
    KOiK08768.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P43884-1) [UniParc]FASTAAdd to Basket

    Also known as: PERIA

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMNKGPTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YNSTKEAHPL    50
    VASVCNAYEK GVQGASNLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE 100
    KIPALQYPPE KIASELKGTI STRLRSARNS ISVPIASTSD KVLGATLAGC 150
    ELALGMAKET AEYAANTRVG RLASGGADLA LGSIEKVVEY LLPPDKVESA 200
    PSSGRQKTQK APKAKPSLLR RVSTLANTLS RHTMQTTARA LKRGHSLAMW 250
    IPGVAPLSSL AQWGASAAMQ VVSRRQSEVR VPWLHNLAAS KDENHEDQTD 300
    TEGEETDEEE EEEESEAEEN VLREVTALPT PLGFLGGVVH TVQKTLQNTI 350
    SAVTWAPAAV LGTVGRILHL TPAQAVSSTK GRAMSLSDAL KGVTDNVVDT 400
    VVHYVPLPRL SLMEPESEFQ DIDNPPAEVE RKGSGSRPAS PESTARPGQP 450
    RAACAVRGLS APSCPDLDDK TETSARPGLL AMPREKPARR VSDSFFRPSV 500
    MEPILGRTQY SQLRKKS 517
    Length:517
    Mass (Da):55,614
    Last modified:November 1, 1995 - v1
    Checksum:i1041F76DC2F55A25
    GO
    Isoform B (identifier: P43884-2) [UniParc]FASTAAdd to Basket

    Also known as: PERIB

    The sequence of this isoform differs from the canonical sequence as follows:
         407-422: LPRLSLMEPESEFQDI → VSPAPGPPSDSQGRFD
         423-517: Missing.

    Show »
    Length:422
    Mass (Da):45,080
    Checksum:iB07043C3ABB4758B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 42216LPRLS…EFQDI → VSPAPGPPSDSQGRFD in isoform B. 1 PublicationVSP_004662Add
    BLAST
    Alternative sequencei423 – 51795Missing in isoform B. 1 PublicationVSP_004663Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26043 mRNA. Translation: AAA41830.1.
    L26044 mRNA. Translation: AAA41831.1.
    PIRiA49413.
    RefSeqiNP_037226.1. NM_013094.1. [P43884-1]
    UniGeneiRn.9737.

    Genome annotation databases

    GeneIDi25629.
    KEGGirno:25629.
    UCSCiRGD:3351. rat. [P43884-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Fat, wonderful fat - Issue 10 of May 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26043 mRNA. Translation: AAA41830.1 .
    L26044 mRNA. Translation: AAA41831.1 .
    PIRi A49413.
    RefSeqi NP_037226.1. NM_013094.1. [P43884-1 ]
    UniGenei Rn.9737.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020559.

    PTM databases

    PhosphoSitei P43884.

    Proteomic databases

    PRIDEi P43884.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25629.
    KEGGi rno:25629.
    UCSCi RGD:3351. rat. [P43884-1 ]

    Organism-specific databases

    CTDi 5346.
    RGDi 3351. Plin1.

    Phylogenomic databases

    eggNOGi NOG75006.
    HOGENOMi HOG000261608.
    InParanoidi P43884.
    KOi K08768.

    Miscellaneous databases

    NextBioi 607427.
    PROi P43884.

    Gene expression databases

    Genevestigatori P43884.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes."
      Greenberg A.S., Egan J.J., Wek S.A., Moos M.C. Jr., Londos C., Kimmel A.R.
      Proc. Natl. Acad. Sci. U.S.A. 90:12035-12039(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Adipocyte.
    2. "Dephosphorylation of perilipin by protein phosphatases present in rat adipocytes."
      Clifford G.M., McCormick D.K., Londos C., Vernon R.G., Yeaman S.J.
      FEBS Lett. 435:125-129(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.

    Entry informationi

    Entry nameiPLIN1_RAT
    AccessioniPrimary (citable) accession number: P43884
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3