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P43883

- PLIN2_MOUSE

UniProt

P43883 - PLIN2_MOUSE

Protein

Perilipin-2

Gene

Plin2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in development and maintenance of adipose tissue.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. lipid storage Source: MGI
    2. long-chain fatty acid transport Source: MGI
    3. response to drug Source: Ensembl
    4. response to organic cyclic compound Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-2
    Alternative name(s):
    Adipophilin
    Adipose differentiation-related protein
    Short name:
    ADRP
    Gene namesi
    Name:Plin2
    Synonyms:Adfp, Adrp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:87920. Plin2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. lipid particle Source: MGI
    4. nucleus Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 425424Perilipin-2PRO_0000099889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP43883.
    PaxDbiP43883.
    PRIDEiP43883.

    PTM databases

    PhosphoSiteiP43883.

    Expressioni

    Tissue specificityi

    Adipose tissue specific. Expressed abundantly and preferentially in fat pads.

    Inductioni

    By dexamethasone.

    Gene expression databases

    ArrayExpressiP43883.
    BgeeiP43883.
    CleanExiMM_ADFP.
    GenevestigatoriP43883.

    Interactioni

    Protein-protein interaction databases

    BioGridi197983. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP43883.
    SMRiP43883. Positions 189-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Phylogenomic databases

    eggNOGiNOG68493.
    GeneTreeiENSGT00500000044795.
    HOGENOMiHOG000033816.
    HOVERGENiHBG002935.
    InParanoidiQ8K3Q8.
    KOiK17284.
    OMAiTKDNHPY.
    OrthoDBiEOG7SN8CD.
    TreeFamiTF328397.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43883-1 [UniParc]FASTAAdd to Basket

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    MAAAVVDPQQ SVVMRVANLP LVSSTYDLVS SAYVSTKDQY PYLRSVCEMA    50
    EKGVKTVTSA AMTSALPIIQ KLEPQIAVAN TYACKGLDRM EERLPILNQP 100
    TSEIVASARG AVTGAKDVVT TTMAGAKDSV ASTVSGVVDK TKGAVTGSVE 150
    RTKSVVNGSI NTVLGMVQFM NSGVDNAITK SELLVDQYFP LTQEELEMEA 200
    KKVEGFDMVQ KPSNYERLES LSTKLCSRAY HQALSRVKEA KQKSQETISQ 250
    LHSTVHLIEF ARKNMHSANQ KIQGAQDKLY VSWVEWKRSI GYDDTDESHC 300
    VEHIESRTLA IARNLTQQLQ TTCQTVLVNA QGLPQNIQDQ AKHLGVMAGD 350
    IYSVFRNAAS FKEVSDGVLT SSKGQLQKMK ESLDEVMDYF VNNTPLNWLV 400
    GPFYPQSTEV NKASLKVQQS EVKAQ 425
    Length:425
    Mass (Da):46,646
    Last modified:July 27, 2011 - v2
    Checksum:iD2624E1BFF335BF9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1831L → M in AAA37176. (PubMed:1518805)Curated
    Sequence conflicti183 – 1831L → M in L09734. (PubMed:8325636)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93275 mRNA. Translation: AAA37176.1.
    L09734 Unassigned DNA. No translation available.
    AY035850 mRNA. Translation: AAK63075.1.
    AK150177 mRNA. Translation: BAE29361.1.
    AK152081 mRNA. Translation: BAE30931.1.
    AK152263 mRNA. Translation: BAE31081.1.
    AK153222 mRNA. Translation: BAE31815.1.
    AK154582 mRNA. Translation: BAE32690.1.
    AK167140 mRNA. Translation: BAE39285.1.
    AL824707 Genomic DNA. Translation: CAM27449.1.
    BC054766 mRNA. Translation: AAH54766.1.
    CCDSiCCDS18308.1.
    PIRiA46251.
    RefSeqiNP_031434.3. NM_007408.3.
    XP_006537620.1. XM_006537557.1.
    UniGeneiMm.381.

    Genome annotation databases

    EnsembliENSMUST00000000466; ENSMUSP00000000466; ENSMUSG00000028494.
    GeneIDi11520.
    KEGGimmu:11520.
    UCSCiuc008tlz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93275 mRNA. Translation: AAA37176.1 .
    L09734 Unassigned DNA. No translation available.
    AY035850 mRNA. Translation: AAK63075.1 .
    AK150177 mRNA. Translation: BAE29361.1 .
    AK152081 mRNA. Translation: BAE30931.1 .
    AK152263 mRNA. Translation: BAE31081.1 .
    AK153222 mRNA. Translation: BAE31815.1 .
    AK154582 mRNA. Translation: BAE32690.1 .
    AK167140 mRNA. Translation: BAE39285.1 .
    AL824707 Genomic DNA. Translation: CAM27449.1 .
    BC054766 mRNA. Translation: AAH54766.1 .
    CCDSi CCDS18308.1.
    PIRi A46251.
    RefSeqi NP_031434.3. NM_007408.3.
    XP_006537620.1. XM_006537557.1.
    UniGenei Mm.381.

    3D structure databases

    ProteinModelPortali P43883.
    SMRi P43883. Positions 189-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 197983. 1 interaction.

    PTM databases

    PhosphoSitei P43883.

    Proteomic databases

    MaxQBi P43883.
    PaxDbi P43883.
    PRIDEi P43883.

    Protocols and materials databases

    DNASUi 11520.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000466 ; ENSMUSP00000000466 ; ENSMUSG00000028494 .
    GeneIDi 11520.
    KEGGi mmu:11520.
    UCSCi uc008tlz.1. mouse.

    Organism-specific databases

    CTDi 123.
    MGIi MGI:87920. Plin2.

    Phylogenomic databases

    eggNOGi NOG68493.
    GeneTreei ENSGT00500000044795.
    HOGENOMi HOG000033816.
    HOVERGENi HBG002935.
    InParanoidi Q8K3Q8.
    KOi K17284.
    OMAi TKDNHPY.
    OrthoDBi EOG7SN8CD.
    TreeFami TF328397.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 278956.
    PROi P43883.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43883.
    Bgeei P43883.
    CleanExi MM_ADFP.
    Genevestigatori P43883.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein."
      Jiang H.P., Serrero G.
      Proc. Natl. Acad. Sci. U.S.A. 89:7856-7860(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adipocyte.
    2. "Structure of the gene encoding mouse adipose differentiation-related protein (ADRP)."
      Eisinger D.P., Serrero G.
      Genomics 16:638-644(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C3H.
      Tissue: Adipose tissue.
    3. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
      Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
      J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPLIN2_MOUSE
    AccessioniPrimary (citable) accession number: P43883
    Secondary accession number(s): Q8K3Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3