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P43883

- PLIN2_MOUSE

UniProt

P43883 - PLIN2_MOUSE

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Protein

Perilipin-2

Gene

Plin2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in development and maintenance of adipose tissue.

GO - Biological processi

  1. lipid storage Source: MGI
  2. long-chain fatty acid transport Source: MGI
  3. response to drug Source: Ensembl
  4. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name:
ADRP
Gene namesi
Name:Plin2
Synonyms:Adfp, Adrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:87920. Plin2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. lipid particle Source: MGI
  4. nucleus Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 425424Perilipin-2PRO_0000099889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP43883.
PaxDbiP43883.
PRIDEiP43883.

PTM databases

PhosphoSiteiP43883.

Expressioni

Tissue specificityi

Adipose tissue specific. Expressed abundantly and preferentially in fat pads.

Inductioni

By dexamethasone.

Gene expression databases

BgeeiP43883.
CleanExiMM_ADFP.
ExpressionAtlasiP43883. baseline and differential.
GenevestigatoriP43883.

Interactioni

Protein-protein interaction databases

BioGridi197983. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP43883.
SMRiP43883. Positions 189-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiNOG68493.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiP43883.
KOiK17284.
OMAiTKDNHPY.
OrthoDBiEOG7SN8CD.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43883-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVVDPQQ SVVMRVANLP LVSSTYDLVS SAYVSTKDQY PYLRSVCEMA
60 70 80 90 100
EKGVKTVTSA AMTSALPIIQ KLEPQIAVAN TYACKGLDRM EERLPILNQP
110 120 130 140 150
TSEIVASARG AVTGAKDVVT TTMAGAKDSV ASTVSGVVDK TKGAVTGSVE
160 170 180 190 200
RTKSVVNGSI NTVLGMVQFM NSGVDNAITK SELLVDQYFP LTQEELEMEA
210 220 230 240 250
KKVEGFDMVQ KPSNYERLES LSTKLCSRAY HQALSRVKEA KQKSQETISQ
260 270 280 290 300
LHSTVHLIEF ARKNMHSANQ KIQGAQDKLY VSWVEWKRSI GYDDTDESHC
310 320 330 340 350
VEHIESRTLA IARNLTQQLQ TTCQTVLVNA QGLPQNIQDQ AKHLGVMAGD
360 370 380 390 400
IYSVFRNAAS FKEVSDGVLT SSKGQLQKMK ESLDEVMDYF VNNTPLNWLV
410 420
GPFYPQSTEV NKASLKVQQS EVKAQ
Length:425
Mass (Da):46,646
Last modified:July 27, 2011 - v2
Checksum:iD2624E1BFF335BF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831L → M in AAA37176. (PubMed:1518805)Curated
Sequence conflicti183 – 1831L → M in L09734. (PubMed:8325636)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93275 mRNA. Translation: AAA37176.1.
L09734 Unassigned DNA. No translation available.
AY035850 mRNA. Translation: AAK63075.1.
AK150177 mRNA. Translation: BAE29361.1.
AK152081 mRNA. Translation: BAE30931.1.
AK152263 mRNA. Translation: BAE31081.1.
AK153222 mRNA. Translation: BAE31815.1.
AK154582 mRNA. Translation: BAE32690.1.
AK167140 mRNA. Translation: BAE39285.1.
AL824707 Genomic DNA. Translation: CAM27449.1.
BC054766 mRNA. Translation: AAH54766.1.
CCDSiCCDS18308.1.
PIRiA46251.
RefSeqiNP_031434.3. NM_007408.3.
XP_006537620.1. XM_006537557.1.
UniGeneiMm.381.

Genome annotation databases

EnsembliENSMUST00000000466; ENSMUSP00000000466; ENSMUSG00000028494.
GeneIDi11520.
KEGGimmu:11520.
UCSCiuc008tlz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93275 mRNA. Translation: AAA37176.1 .
L09734 Unassigned DNA. No translation available.
AY035850 mRNA. Translation: AAK63075.1 .
AK150177 mRNA. Translation: BAE29361.1 .
AK152081 mRNA. Translation: BAE30931.1 .
AK152263 mRNA. Translation: BAE31081.1 .
AK153222 mRNA. Translation: BAE31815.1 .
AK154582 mRNA. Translation: BAE32690.1 .
AK167140 mRNA. Translation: BAE39285.1 .
AL824707 Genomic DNA. Translation: CAM27449.1 .
BC054766 mRNA. Translation: AAH54766.1 .
CCDSi CCDS18308.1.
PIRi A46251.
RefSeqi NP_031434.3. NM_007408.3.
XP_006537620.1. XM_006537557.1.
UniGenei Mm.381.

3D structure databases

ProteinModelPortali P43883.
SMRi P43883. Positions 189-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197983. 1 interaction.

PTM databases

PhosphoSitei P43883.

Proteomic databases

MaxQBi P43883.
PaxDbi P43883.
PRIDEi P43883.

Protocols and materials databases

DNASUi 11520.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000466 ; ENSMUSP00000000466 ; ENSMUSG00000028494 .
GeneIDi 11520.
KEGGi mmu:11520.
UCSCi uc008tlz.1. mouse.

Organism-specific databases

CTDi 123.
MGIi MGI:87920. Plin2.

Phylogenomic databases

eggNOGi NOG68493.
GeneTreei ENSGT00500000044795.
HOGENOMi HOG000033816.
HOVERGENi HBG002935.
InParanoidi P43883.
KOi K17284.
OMAi TKDNHPY.
OrthoDBi EOG7SN8CD.
TreeFami TF328397.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 278956.
PROi P43883.
SOURCEi Search...

Gene expression databases

Bgeei P43883.
CleanExi MM_ADFP.
ExpressionAtlasi P43883. baseline and differential.
Genevestigatori P43883.

Family and domain databases

InterProi IPR004279. Perilipin.
[Graphical view ]
PANTHERi PTHR14024. PTHR14024. 1 hit.
Pfami PF03036. Perilipin. 1 hit.
[Graphical view ]
PIRSFi PIRSF036881. PAT. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein."
    Jiang H.P., Serrero G.
    Proc. Natl. Acad. Sci. U.S.A. 89:7856-7860(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipocyte.
  2. "Structure of the gene encoding mouse adipose differentiation-related protein (ADRP)."
    Eisinger D.P., Serrero G.
    Genomics 16:638-644(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C3H.
    Tissue: Adipose tissue.
  3. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
    Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
    J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPLIN2_MOUSE
AccessioniPrimary (citable) accession number: P43883
Secondary accession number(s): Q8K3Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3