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P43883 (PLIN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name=ADRP
Gene names
Name:Plin2
Synonyms:Adfp, Adrp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in development and maintenance of adipose tissue.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Adipose tissue specific. Expressed abundantly and preferentially in fat pads.

Induction

By dexamethasone.

Sequence similarities

Belongs to the perilipin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 425424Perilipin-2
PRO_0000099889

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict1831L → M in AAA37176. Ref.1
Sequence conflict1831L → M in L09734. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P43883 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: D2624E1BFF335BF9

FASTA42546,646
        10         20         30         40         50         60 
MAAAVVDPQQ SVVMRVANLP LVSSTYDLVS SAYVSTKDQY PYLRSVCEMA EKGVKTVTSA 

        70         80         90        100        110        120 
AMTSALPIIQ KLEPQIAVAN TYACKGLDRM EERLPILNQP TSEIVASARG AVTGAKDVVT 

       130        140        150        160        170        180 
TTMAGAKDSV ASTVSGVVDK TKGAVTGSVE RTKSVVNGSI NTVLGMVQFM NSGVDNAITK 

       190        200        210        220        230        240 
SELLVDQYFP LTQEELEMEA KKVEGFDMVQ KPSNYERLES LSTKLCSRAY HQALSRVKEA 

       250        260        270        280        290        300 
KQKSQETISQ LHSTVHLIEF ARKNMHSANQ KIQGAQDKLY VSWVEWKRSI GYDDTDESHC 

       310        320        330        340        350        360 
VEHIESRTLA IARNLTQQLQ TTCQTVLVNA QGLPQNIQDQ AKHLGVMAGD IYSVFRNAAS 

       370        380        390        400        410        420 
FKEVSDGVLT SSKGQLQKMK ESLDEVMDYF VNNTPLNWLV GPFYPQSTEV NKASLKVQQS 


EVKAQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein."
Jiang H.P., Serrero G.
Proc. Natl. Acad. Sci. U.S.A. 89:7856-7860(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adipocyte.
[2]"Structure of the gene encoding mouse adipose differentiation-related protein (ADRP)."
Eisinger D.P., Serrero G.
Genomics 16:638-644(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C3H.
Tissue: Adipose tissue.
[3]"Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M93275 mRNA. Translation: AAA37176.1.
L09734 Unassigned DNA. No translation available.
AY035850 mRNA. Translation: AAK63075.1.
AK150177 mRNA. Translation: BAE29361.1.
AK152081 mRNA. Translation: BAE30931.1.
AK152263 mRNA. Translation: BAE31081.1.
AK153222 mRNA. Translation: BAE31815.1.
AK154582 mRNA. Translation: BAE32690.1.
AK167140 mRNA. Translation: BAE39285.1.
AL824707 Genomic DNA. Translation: CAM27449.1.
BC054766 mRNA. Translation: AAH54766.1.
CCDSCCDS18308.1.
PIRA46251.
RefSeqNP_031434.3. NM_007408.3.
XP_006537620.1. XM_006537557.1.
UniGeneMm.381.

3D structure databases

ProteinModelPortalP43883.
SMRP43883. Positions 189-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid197983. 1 interaction.

PTM databases

PhosphoSiteP43883.

Proteomic databases

MaxQBP43883.
PaxDbP43883.
PRIDEP43883.

Protocols and materials databases

DNASU11520.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000466; ENSMUSP00000000466; ENSMUSG00000028494.
GeneID11520.
KEGGmmu:11520.
UCSCuc008tlz.1. mouse.

Organism-specific databases

CTD123.
MGIMGI:87920. Plin2.

Phylogenomic databases

eggNOGNOG68493.
GeneTreeENSGT00500000044795.
HOGENOMHOG000033816.
HOVERGENHBG002935.
InParanoidQ8K3Q8.
KOK17284.
OMATKDNHPY.
OrthoDBEOG7SN8CD.
TreeFamTF328397.

Gene expression databases

ArrayExpressP43883.
BgeeP43883.
CleanExMM_ADFP.
GenevestigatorP43883.

Family and domain databases

InterProIPR004279. Perilipin.
[Graphical view]
PANTHERPTHR14024. PTHR14024. 1 hit.
PfamPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFPIRSF036881. PAT. 1 hit.
ProtoNetSearch...

Other

NextBio278956.
PROP43883.
SOURCESearch...

Entry information

Entry namePLIN2_MOUSE
AccessionPrimary (citable) accession number: P43883
Secondary accession number(s): Q8K3Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot