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Protein

Perilipin-2

Gene

Plin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in development and maintenance of adipose tissue.1 Publication

GO - Biological processi

  • lipid storage Source: MGI
  • long-chain fatty acid transport Source: MGI
  • response to drug Source: Ensembl
  • response to organic cyclic compound Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein2 Publications
Short name:
ADRP1 Publication
Gene namesi
Name:Plin2
Synonyms:Adfp, Adrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:87920. Plin2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998892 – 425Perilipin-2Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei213PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP43883.
MaxQBiP43883.
PaxDbiP43883.
PeptideAtlasiP43883.
PRIDEiP43883.

PTM databases

iPTMnetiP43883.
PhosphoSitePlusiP43883.
SwissPalmiP43883.

Expressioni

Tissue specificityi

Adipose tissue specific. Expressed abundantly and preferentially in fat pads.1 Publication

Inductioni

By dexamethasone.

Gene expression databases

BgeeiENSMUSG00000028494.
CleanExiMM_ADFP.
ExpressionAtlasiP43883. baseline and differential.
GenevisibleiP43883. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hspa8P630173EBI-16156700,EBI-433443

Protein-protein interaction databases

BioGridi197983. 1 interactor.
DIPiDIP-61639N.
IntActiP43883. 1 interactor.
STRINGi10090.ENSMUSP00000000466.

Structurei

3D structure databases

ProteinModelPortaliP43883.
SMRiP43883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiENOG410IJG1. Eukaryota.
ENOG410XTQ5. LUCA.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiP43883.
KOiK17284.
OMAiTSAMPII.
OrthoDBiEOG091G0D6Q.
TreeFamiTF328397.

Family and domain databases

InterProiView protein in InterPro
IPR004279. Perilipin.
PfamiView protein in Pfam
PF03036. Perilipin. 1 hit.
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVVDPQQ SVVMRVANLP LVSSTYDLVS SAYVSTKDQY PYLRSVCEMA
60 70 80 90 100
EKGVKTVTSA AMTSALPIIQ KLEPQIAVAN TYACKGLDRM EERLPILNQP
110 120 130 140 150
TSEIVASARG AVTGAKDVVT TTMAGAKDSV ASTVSGVVDK TKGAVTGSVE
160 170 180 190 200
RTKSVVNGSI NTVLGMVQFM NSGVDNAITK SELLVDQYFP LTQEELEMEA
210 220 230 240 250
KKVEGFDMVQ KPSNYERLES LSTKLCSRAY HQALSRVKEA KQKSQETISQ
260 270 280 290 300
LHSTVHLIEF ARKNMHSANQ KIQGAQDKLY VSWVEWKRSI GYDDTDESHC
310 320 330 340 350
VEHIESRTLA IARNLTQQLQ TTCQTVLVNA QGLPQNIQDQ AKHLGVMAGD
360 370 380 390 400
IYSVFRNAAS FKEVSDGVLT SSKGQLQKMK ESLDEVMDYF VNNTPLNWLV
410 420
GPFYPQSTEV NKASLKVQQS EVKAQ
Length:425
Mass (Da):46,646
Last modified:July 27, 2011 - v2
Checksum:iD2624E1BFF335BF9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183L → M in AAA37176 (PubMed:1518805).Curated1
Sequence conflicti183L → M in L09734 (PubMed:8325636).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93275 mRNA. Translation: AAA37176.1.
L09734 Unassigned DNA. No translation available.
AY035850 mRNA. Translation: AAK63075.1.
AK150177 mRNA. Translation: BAE29361.1.
AK152081 mRNA. Translation: BAE30931.1.
AK152263 mRNA. Translation: BAE31081.1.
AK153222 mRNA. Translation: BAE31815.1.
AK154582 mRNA. Translation: BAE32690.1.
AK167140 mRNA. Translation: BAE39285.1.
AL824707 Genomic DNA. Translation: CAM27449.1.
BC054766 mRNA. Translation: AAH54766.1.
CCDSiCCDS18308.1.
PIRiA46251.
RefSeqiNP_031434.3. NM_007408.3.
XP_006537620.1. XM_006537557.1.
UniGeneiMm.381.

Genome annotation databases

EnsembliENSMUST00000000466; ENSMUSP00000000466; ENSMUSG00000028494.
GeneIDi11520.
KEGGimmu:11520.
UCSCiuc008tlz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPLIN2_MOUSE
AccessioniPrimary (citable) accession number: P43883
Secondary accession number(s): Q8K3Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families