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P43876 (AROE_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:HI_0655
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Subunit structure

Monomer. Ref.2

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Shikimate dehydrogenase HAMAP MF_00222
PRO_0000136006

Regions

Nucleotide binding126 – 1305NADP HAMAP MF_00222
Nucleotide binding149 – 1546NADP HAMAP MF_00222
Nucleotide binding238 – 2425NADP By similarity

Sites

Active site651Proton acceptor Potential
Binding site1021Substrate By similarity
Binding site1891NADP; via amide nitrogen
Binding site1901NADP; via amide nitrogen

Secondary structure

1 .................................................... 272
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43876 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3B7A92AF22D4470B

FASTA27229,760
        10         20         30         40         50         60 
MDLYAVWGNP IAQSKSPLIQ NKLAAQTHQT MEYIAKLGDL DAFEQQLLAF FEEGAKGCNI 

        70         80         90        100        110        120 
TSPFKERAYQ LADEYSQRAK LAEACNTLKK LDDGKLYADN TDGIGLVTDL QRLNWLRPNQ 

       130        140        150        160        170        180 
HVLILGAGGA TKGVLLPLLQ AQQNIVLANR TFSKTKELAE RFQPYGNIQA VSMDSIPLQT 

       190        200        210        220        230        240 
YDLVINATSA GLSGGTASVD AEILKLGSAF YDMQYAKGTD TPFIALCKSL GLTNVSDGFG 

       250        260        270 
MLVAQAAHSF HLWRGVMPDF VSVYEQLKKA ML

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22314.1.
PIRH64084.
RefSeqNP_438815.1. NC_000907.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1P74X-ray2.40A/B1-272[»]
1P77X-ray1.95A1-272[»]
ProteinModelPortalP43876.
SMRP43876. Positions 1-272.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949697.
GenomeReviewsGene locus HI_0655 in contig L42023_GR.
KEGGhin:HI0655.
NMPDRfig|71421.1.peg.625.
PATRIC20189925. VBIHaeInf48452_0684.
TIGRHI_0655.

Phylogenomic databases

HOGENOMHBG553408.
OMAVVFGNPI.
ProtClustDBPRK00258.

Enzyme and pathway databases

BioCycHINF71421:HI_0655-MONOMER.
BRENDA1.1.1.25. 2529.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_HAEIN
AccessionPrimary (citable) accession number: P43876
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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