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P43871

- MTH3_HAEIN

UniProt

P43871 - MTH3_HAEIN

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Protein

Modification methylase HindIII

Gene

hindIIIM

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

This methylase recognizes the double-stranded sequence AAGCTT, causes specific methylation on A-1 on both strands, and protects the DNA from cleavage by the HindIII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3428. M.HindIII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HindIII (EC:2.1.1.72)
Short name:
M.HindIII
Alternative name(s):
Adenine-specific methyltransferase HindIII
Gene namesi
Name:hindIIIM
Ordered Locus Names:HI_1392
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Modification methylase HindIIIPRO_0000087964Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1392.

Structurei

3D structure databases

ProteinModelPortaliP43871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0863.
KOiK00571.
OMAiNENSLTH.
OrthoDBiEOG6FV84T.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequencei

Sequence statusi: Complete.

P43871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDCIYNSDS IFEIKKLDSN SIHAIISDIP YGIDYDDWDI LHSNTNSALG
60 70 80 90 100
GTSSAQHKTS LFKRRGKPLN GWSEADKKRP QEYQEWVESW SNEWFRVLKS
110 120 130 140 150
GSSVFVFAGR QFAHRVVVAF ENSGFTFKDM LSWEKDKAPH RAQRISCVFE
160 170 180 190 200
RRGDIANTNK WVGWRVANLR PLFEPILWFQ KPYKTGSTLA DNLIKHEVGA
210 220 230 240 250
WNENSLTHWN IQQGALNHSN ILKVRITSED KGYHVAQKPL NLMKLLIDLV
260 270 280 290 300
TKEEQIVLDP FAGSGTTLLA AKELNRHFIG YEKNNGIYNI AVNRLGIEKN

NCFYNKEKK
Length:309
Mass (Da):35,550
Last modified:November 1, 1995 - v1
Checksum:i954E04023326E061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA. Translation: AAA61959.1.
L42023 Genomic DNA. Translation: AAC23039.1.
RefSeqiNP_439546.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23039; AAC23039; HI_1392.
GeneIDi950302.
KEGGihin:HI1392.
PATRICi20191481. VBIHaeInf48452_1451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA. Translation: AAA61959.1 .
L42023 Genomic DNA. Translation: AAC23039.1 .
RefSeqi NP_439546.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43871.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1392.

Protein family/group databases

REBASEi 3428. M.HindIII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23039 ; AAC23039 ; HI_1392 .
GeneIDi 950302.
KEGGi hin:HI1392.
PATRICi 20191481. VBIHaeInf48452_1451.

Phylogenomic databases

eggNOGi COG0863.
KOi K00571.
OMAi NENSLTH.
OrthoDBi EOG6FV84T.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, analysis and expression of the HindIII R-M-encoding genes."
    Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G.
    Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-16.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiMTH3_HAEIN
AccessioniPrimary (citable) accession number: P43871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3