Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43871 (MTH3_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase HindIII

Short name=M.HindIII
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase HindIII
Gene names
Name:hindIIIM
Ordered Locus Names:HI_1392
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence AAGCTT, causes specific methylation on A-1 on both strands, and protects the DNA from cleavage by the HindIII endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Modification methylase HindIII
PRO_0000087964

Sequences

Sequence LengthMass (Da)Tools
P43871 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 954E04023326E061

FASTA30935,550
        10         20         30         40         50         60 
MIDCIYNSDS IFEIKKLDSN SIHAIISDIP YGIDYDDWDI LHSNTNSALG GTSSAQHKTS 

        70         80         90        100        110        120 
LFKRRGKPLN GWSEADKKRP QEYQEWVESW SNEWFRVLKS GSSVFVFAGR QFAHRVVVAF 

       130        140        150        160        170        180 
ENSGFTFKDM LSWEKDKAPH RAQRISCVFE RRGDIANTNK WVGWRVANLR PLFEPILWFQ 

       190        200        210        220        230        240 
KPYKTGSTLA DNLIKHEVGA WNENSLTHWN IQQGALNHSN ILKVRITSED KGYHVAQKPL 

       250        260        270        280        290        300 
NLMKLLIDLV TKEEQIVLDP FAGSGTTLLA AKELNRHFIG YEKNNGIYNI AVNRLGIEKN 


NCFYNKEKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L15391 Genomic DNA. Translation: AAA61959.1.
L42023 Genomic DNA. Translation: AAC23039.1.
RefSeqNP_439546.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43871.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1392.

Protein family/group databases

REBASE3428. M.HindIII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23039; AAC23039; HI_1392.
GeneID950302.
KEGGhin:HI1392.
PATRIC20191481. VBIHaeInf48452_1451.

Phylogenomic databases

eggNOGCOG0863.
KOK00571.
OMARAQRISC.
OrthoDBEOG6FV84T.
ProtClustDBCLSK892404.

Family and domain databases

InterProIPR002941. DNA_methylase_N4/N6.
IPR001091. RM_Methylase.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
ProtoNetSearch...

Entry information

Entry nameMTH3_HAEIN
AccessionPrimary (citable) accession number: P43871
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names