Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43870

- T2D3_HAEIN

UniProt

P43870 - T2D3_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Type-2 restriction enzyme HindIII

Gene

hindIIIR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1151. HindIII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HindIII (EC:3.1.21.4)
Short name:
R.HindIII
Alternative name(s):
Endonuclease HindIII
Type II restriction enzyme HindIII
Gene namesi
Name:hindIIIR
Ordered Locus Names:HI_1393
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Type-2 restriction enzyme HindIIIPRO_0000077321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1393.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Turni16 – 183Combined sources
Helixi21 – 3313Combined sources
Helixi37 – 4711Combined sources
Helixi59 – 7820Combined sources
Beta strandi81 – 855Combined sources
Beta strandi94 – 10310Combined sources
Beta strandi105 – 1106Combined sources
Helixi122 – 1254Combined sources
Helixi127 – 1337Combined sources
Turni134 – 1363Combined sources
Beta strandi137 – 1448Combined sources
Helixi146 – 1483Combined sources
Beta strandi151 – 1533Combined sources
Helixi155 – 1639Combined sources
Beta strandi165 – 1695Combined sources
Helixi170 – 1789Combined sources
Helixi190 – 1934Combined sources
Helixi195 – 2006Combined sources
Helixi205 – 2073Combined sources
Helixi213 – 22412Combined sources
Helixi228 – 26134Combined sources
Helixi265 – 27511Combined sources
Helixi278 – 29316Combined sources
Helixi295 – 2984Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E52X-ray2.00A/B/C/D1-300[»]
3A4KX-ray2.17A/B/C/D1-300[»]
ProteinModelPortaliP43870.
SMRiP43870. Positions 2-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43870.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45031.
KOiK01155.
OMAiDINMSSK.
OrthoDBiEOG686NN8.

Family and domain databases

InterProiIPR019043. Restrct_endonuc_II_HindIII.
[Graphical view]
PfamiPF09518. RE_HindIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKSALEKLL SLIENLTNQE FKQATNSLIS FIYKLNRNEV IELVRSIGIL
60 70 80 90 100
PEAIKPSSTQ EKLFSKAGDI VLAKAFQLLN LNSKPLEQRG NAGDVIALSK
110 120 130 140 150
EFNYGLVADA KSFRLSRTAK NQKDFKVKAL SEWREDKDYA VLTAPFFQYP
160 170 180 190 200
TTKSQIFKQS LDENVLLFSW EHLAILLQLD LEETNIFSFE QLWNFPKKQS
210 220 230 240 250
KKTSVSDAEN NFMRDFNKYF MDLFKIDKDT LNQLLQKEIN FIEERSLIEK
260 270 280 290 300
EYWKKQINII KNFTREEAIE ALLKDINMSS KIETIDSFIK GIKSNDRLYL
Length:300
Mass (Da):34,952
Last modified:November 1, 1995 - v1
Checksum:i62F62AC4B18E841B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA. Translation: AAA61958.1.
L42023 Genomic DNA. Translation: AAC23040.1.
PIRiH64121.
RefSeqiNP_439547.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23040; AAC23040; HI_1393.
GeneIDi950303.
KEGGihin:HI1393.
PATRICi20191483. VBIHaeInf48452_1452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15391 Genomic DNA. Translation: AAA61958.1 .
L42023 Genomic DNA. Translation: AAC23040.1 .
PIRi H64121.
RefSeqi NP_439547.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E52 X-ray 2.00 A/B/C/D 1-300 [» ]
3A4K X-ray 2.17 A/B/C/D 1-300 [» ]
ProteinModelPortali P43870.
SMRi P43870. Positions 2-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1393.

Chemistry

BindingDBi P43870.
ChEMBLi CHEMBL5004.

Protein family/group databases

REBASEi 1151. HindIII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23040 ; AAC23040 ; HI_1393 .
GeneIDi 950303.
KEGGi hin:HI1393.
PATRICi 20191483. VBIHaeInf48452_1452.

Phylogenomic databases

eggNOGi NOG45031.
KOi K01155.
OMAi DINMSSK.
OrthoDBi EOG686NN8.

Miscellaneous databases

EvolutionaryTracei P43870.

Family and domain databases

InterProi IPR019043. Restrct_endonuc_II_HindIII.
[Graphical view ]
Pfami PF09518. RE_HindIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, analysis and expression of the HindIII R-M-encoding genes."
    Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G.
    Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-26.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT2D3_HAEIN
AccessioniPrimary (citable) accession number: P43870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3