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P43870

- T2D3_HAEIN

UniProt

P43870 - T2D3_HAEIN

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Protein
Type-2 restriction enzyme HindIII
Gene
hindIIIR, HI_1393
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1151. HindIII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme HindIII (EC:3.1.21.4)
Short name:
R.HindIII
Alternative name(s):
Endonuclease HindIII
Type II restriction enzyme HindIII
Gene namesi
Name:hindIIIR
Ordered Locus Names:HI_1393
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Type-2 restriction enzyme HindIII
PRO_0000077321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1393.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511
Turni16 – 183
Helixi21 – 3313
Helixi37 – 4711
Helixi59 – 7820
Beta strandi81 – 855
Beta strandi94 – 10310
Beta strandi105 – 1106
Helixi122 – 1254
Helixi127 – 1337
Turni134 – 1363
Beta strandi137 – 1448
Helixi146 – 1483
Beta strandi151 – 1533
Helixi155 – 1639
Beta strandi165 – 1695
Helixi170 – 1789
Helixi190 – 1934
Helixi195 – 2006
Helixi205 – 2073
Helixi213 – 22412
Helixi228 – 26134
Helixi265 – 27511
Helixi278 – 29316
Helixi295 – 2984

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E52X-ray2.00A/B/C/D1-300[»]
3A4KX-ray2.17A/B/C/D1-300[»]
ProteinModelPortaliP43870.
SMRiP43870. Positions 2-300.

Miscellaneous databases

EvolutionaryTraceiP43870.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45031.
KOiK01155.
OMAiDINMSSK.
OrthoDBiEOG686NN8.

Family and domain databases

InterProiIPR019043. Restrct_endonuc_II_HindIII.
[Graphical view]
PfamiPF09518. RE_HindIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43870-1 [UniParc]FASTAAdd to Basket

« Hide

MKKSALEKLL SLIENLTNQE FKQATNSLIS FIYKLNRNEV IELVRSIGIL    50
PEAIKPSSTQ EKLFSKAGDI VLAKAFQLLN LNSKPLEQRG NAGDVIALSK 100
EFNYGLVADA KSFRLSRTAK NQKDFKVKAL SEWREDKDYA VLTAPFFQYP 150
TTKSQIFKQS LDENVLLFSW EHLAILLQLD LEETNIFSFE QLWNFPKKQS 200
KKTSVSDAEN NFMRDFNKYF MDLFKIDKDT LNQLLQKEIN FIEERSLIEK 250
EYWKKQINII KNFTREEAIE ALLKDINMSS KIETIDSFIK GIKSNDRLYL 300
Length:300
Mass (Da):34,952
Last modified:November 1, 1995 - v1
Checksum:i62F62AC4B18E841B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15391 Genomic DNA. Translation: AAA61958.1.
L42023 Genomic DNA. Translation: AAC23040.1.
PIRiH64121.
RefSeqiNP_439547.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23040; AAC23040; HI_1393.
GeneIDi950303.
KEGGihin:HI1393.
PATRICi20191483. VBIHaeInf48452_1452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15391 Genomic DNA. Translation: AAA61958.1 .
L42023 Genomic DNA. Translation: AAC23040.1 .
PIRi H64121.
RefSeqi NP_439547.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E52 X-ray 2.00 A/B/C/D 1-300 [» ]
3A4K X-ray 2.17 A/B/C/D 1-300 [» ]
ProteinModelPortali P43870.
SMRi P43870. Positions 2-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1393.

Chemistry

BindingDBi P43870.
ChEMBLi CHEMBL5004.

Protein family/group databases

REBASEi 1151. HindIII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23040 ; AAC23040 ; HI_1393 .
GeneIDi 950303.
KEGGi hin:HI1393.
PATRICi 20191483. VBIHaeInf48452_1452.

Phylogenomic databases

eggNOGi NOG45031.
KOi K01155.
OMAi DINMSSK.
OrthoDBi EOG686NN8.

Miscellaneous databases

EvolutionaryTracei P43870.

Family and domain databases

InterProi IPR019043. Restrct_endonuc_II_HindIII.
[Graphical view ]
Pfami PF09518. RE_HindIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, analysis and expression of the HindIII R-M-encoding genes."
    Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G.
    Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-26.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT2D3_HAEIN
AccessioniPrimary (citable) accession number: P43870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3

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