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P43869 (P5CR_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrroline-5-carboxylate reductase

Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2
Gene names
Name:proC
Ordered Locus Names:HI_0307
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpyrroline-5-carboxylate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Pyrroline-5-carboxylate reductase
PRO_0000187290

Sequences

Sequence LengthMass (Da)Tools
P43869 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 132B69A9CEAE8B35

FASTA27129,124
        10         20         30         40         50         60 
MQHKLIAFIG GGNMAQAIIL GLLKQGYPAE QIIVNDPNEE KRAFFANLDV ATSENNVGSA 

        70         80         90        100        110        120 
IKAEVVLLAV KPQMMAEVCS PLSAVDFSDK LLISIAAGIS TERLNALIPS VKSIVRVMPN 

       130        140        150        160        170        180 
TPALVGEGMA GLFAPKNTSE NYRTFAQDLL GAVGRTVWVN DETQMHAVTA ASGSSPAYFF 

       190        200        210        220        230        240 
LMLEAMQKAL IKMNIDEKTA RELVQQSMLG AAKMVTENPQ IALSTLRENV TSKGGTTAAA 

       250        260        270 
LAVFDAQHFN QTIEQAMQAC LSRSQEMETL F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21972.1.
PIRI64060.
RefSeqNP_438474.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43869.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21972; AAC21972; HI_0307.
GeneID949427.
KEGGhin:HI0307.
PATRIC20189155. VBIHaeInf48452_0324.

Phylogenomic databases

eggNOGCOG0345.
KOK00286.
OMAYFFLMLE.
OrthoDBEOG6JB16S.
ProtClustDBPRK11880.

Enzyme and pathway databases

UniPathwayUPA00098; UER00361.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERPTHR11645. PTHR11645. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00112. proC. 1 hit.
PROSITEPS00521. P5CR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP5CR_HAEIN
AccessionPrimary (citable) accession number: P43869
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names