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P43866 (GCH1_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:HI_1447
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119411

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P43866 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BCC60F0038158D38

FASTA21824,945
        10         20         30         40         50         60 
MSKISLDALN VRNALIEKGI ETPMIDPTQA KNERRESIAK HMHEVMKLIG LDLRDDSLEE 

        70         80         90        100        110        120 
TPNRLAKMFI DEIFSGMDYA NFPKMTKIKN QMKVSEMVQV NDITLTSTCE HHFVTIDGKV 

       130        140        150        160        170        180 
CVAYYPKDWV IGLSKINRIV SFFAQRPQVQ ERLTEQLLTA FQTILETDDV AVYVKATHFC 

       190        200        210 
VKARGIRDTN SYTVTSAYGG VFLEDRDTRK EFLATVQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23097.1.
PIRA64124.
RefSeqNP_439599.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43866.
SMRP43866. Positions 4-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23097; AAC23097; HI_1447.
GeneID950345.
KEGGhin:HI1447.
PATRIC20191599. VBIHaeInf48452_1509.

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMADECSHTI.
OrthoDBEOG6XHC8G.
PhylomeDBP43866.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_HAEIN
AccessionPrimary (citable) accession number: P43866
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names