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Protein

Lon protease

Gene

lon

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei679 – 6791UniRule annotation
Active sitei722 – 7221UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi356 – 3638ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Synonyms:lon-A
Ordered Locus Names:HI_0462
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Lon proteasePRO_0000076136Add
BLAST

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0462.

Structurei

3D structure databases

ProteinModelPortaliP43864.
SMRiP43864. Positions 9-111, 491-584, 594-781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 200192Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini592 – 773182Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiYLLGMME.
OrthoDBiEOG6XHC23.
PhylomeDBiP43864.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNTQRTMP VLPLRDVVVF PYMVMPLFVG RAKSINALEE AMNDDKQILL
60 70 80 90 100
VSQREADLEE PTPEDLFDVG TIANIIQLLK LPDDTVKVLV EGQNRAKINS
110 120 130 140 150
LEDGEKCFSA QITPIETTYG DEKELVVAKS AVLSEFENYL TLNKKVPTDI
160 170 180 190 200
LNALQRIDDV DRLADTMAAH LPVSIRHKQN ALELANVQER LEYLLGMMES
210 220 230 240 250
EADILQVEKR IRGRVKKQME KSQRNYYLNE QIKAIRKEMD GGENEDTIDE
260 270 280 290 300
VEQLHQKVEA AGMPADVRDK VENELQKLKM MSAMSSEATV IRSYIEWMIQ
310 320 330 340 350
VPWHQRSKVK KDIVKAQQVL DTDHYGLDRV KERILEYLAV QARLNKVKGP
360 370 380 390 400
ILCLVGPPGV GKTSLGQSIA NATGRKYVRM ALGGVRDEAE IRGHRKTYIG
410 420 430 440 450
ALPGKLIQKM AKVGVKNPLF LLDEIDKMAS DMRGDPASAL LEVLDPEQNT
460 470 480 490 500
TFNDHYLEVD YDLSDVMFVA TSNSMNIPGP LLDRMEVIRL SGYTEDEKLN
510 520 530 540 550
IAMRHLLAKQ IERNGLKKGE LTVEESAILD IIRYYTREAG VRGLEREISK
560 570 580 590 600
ICRKAVKNLL VNPKLKSITV NSDNLHDYLG VKRFEFGKAD TQNRIGEVTG
610 620 630 640 650
LAWTEVGGDL LTIETASVVG KGKLSFTGSL GDVMKESIQA AMTVVRARAD
660 670 680 690 700
KLGINAEFHE KRDIHIHVPD GATPKDGPSA GIAMCTALIS CLTGNPVRAD
710 720 730 740 750
VAMTGEISLR GKVLPIGGLK EKLLAAHRGG IKTVLIPKEN VKDLEEIPEN
760 770 780 790 800
VKQNLAIHAV ETIDEVLGFA LENPPEGIEF VKVEAKPKAP RRKVTSKSER

AVN
Length:803
Mass (Da):89,347
Last modified:November 1, 1995 - v1
Checksum:i9E590852611EEA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22121.1.
PIRiA64070.
RefSeqiNP_438623.1. NC_000907.1.
WP_005693703.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22121; AAC22121; HI_0462.
GeneIDi949549.
KEGGihin:HI0462.
PATRICi20189479. VBIHaeInf48452_0482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22121.1.
PIRiA64070.
RefSeqiNP_438623.1. NC_000907.1.
WP_005693703.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43864.
SMRiP43864. Positions 9-111, 491-584, 594-781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0462.

Protein family/group databases

MEROPSiS16.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22121; AAC22121; HI_0462.
GeneIDi949549.
KEGGihin:HI0462.
PATRICi20189479. VBIHaeInf48452_0482.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiYLLGMME.
OrthoDBiEOG6XHC23.
PhylomeDBiP43864.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiLON_HAEIN
AccessioniPrimary (citable) accession number: P43864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.