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Protein

Lon protease

Gene

lon

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei679UniRule annotation1
Active sitei722UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 363ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-478-MONOMER

Protein family/group databases

MEROPSiS16.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Synonyms:lon-A
Ordered Locus Names:HI_0462
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761361 – 803Lon proteaseAdd BLAST803

Proteomic databases

PRIDEiP43864

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI0462

Structurei

3D structure databases

ProteinModelPortaliP43864
SMRiP43864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 200Lon N-terminalPROSITE-ProRule annotationAdd BLAST192
Domaini592 – 773Lon proteolyticPROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P Bacteria
COG0466 LUCA
KOiK01338
OMAiPILCLYG
PhylomeDBiP43864

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_01973 lon_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027543 Lon_bac
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P43864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNTQRTMP VLPLRDVVVF PYMVMPLFVG RAKSINALEE AMNDDKQILL
60 70 80 90 100
VSQREADLEE PTPEDLFDVG TIANIIQLLK LPDDTVKVLV EGQNRAKINS
110 120 130 140 150
LEDGEKCFSA QITPIETTYG DEKELVVAKS AVLSEFENYL TLNKKVPTDI
160 170 180 190 200
LNALQRIDDV DRLADTMAAH LPVSIRHKQN ALELANVQER LEYLLGMMES
210 220 230 240 250
EADILQVEKR IRGRVKKQME KSQRNYYLNE QIKAIRKEMD GGENEDTIDE
260 270 280 290 300
VEQLHQKVEA AGMPADVRDK VENELQKLKM MSAMSSEATV IRSYIEWMIQ
310 320 330 340 350
VPWHQRSKVK KDIVKAQQVL DTDHYGLDRV KERILEYLAV QARLNKVKGP
360 370 380 390 400
ILCLVGPPGV GKTSLGQSIA NATGRKYVRM ALGGVRDEAE IRGHRKTYIG
410 420 430 440 450
ALPGKLIQKM AKVGVKNPLF LLDEIDKMAS DMRGDPASAL LEVLDPEQNT
460 470 480 490 500
TFNDHYLEVD YDLSDVMFVA TSNSMNIPGP LLDRMEVIRL SGYTEDEKLN
510 520 530 540 550
IAMRHLLAKQ IERNGLKKGE LTVEESAILD IIRYYTREAG VRGLEREISK
560 570 580 590 600
ICRKAVKNLL VNPKLKSITV NSDNLHDYLG VKRFEFGKAD TQNRIGEVTG
610 620 630 640 650
LAWTEVGGDL LTIETASVVG KGKLSFTGSL GDVMKESIQA AMTVVRARAD
660 670 680 690 700
KLGINAEFHE KRDIHIHVPD GATPKDGPSA GIAMCTALIS CLTGNPVRAD
710 720 730 740 750
VAMTGEISLR GKVLPIGGLK EKLLAAHRGG IKTVLIPKEN VKDLEEIPEN
760 770 780 790 800
VKQNLAIHAV ETIDEVLGFA LENPPEGIEF VKVEAKPKAP RRKVTSKSER

AVN
Length:803
Mass (Da):89,347
Last modified:November 1, 1995 - v1
Checksum:i9E590852611EEA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22121.1
PIRiA64070
RefSeqiNP_438623.1, NC_000907.1
WP_005693703.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22121; AAC22121; HI_0462
GeneIDi949549
KEGGihin:HI0462
PATRICifig|71421.8.peg.482

Similar proteinsi

Entry informationi

Entry nameiLON_HAEIN
AccessioniPrimary (citable) accession number: P43864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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