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P43864 (LON_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lon protease
EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Synonyms:lon-A
Ordered Locus Names:HI_0462
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length803 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm.

Induction

By heat shock By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 803803Lon protease
PRO_0000076136

Regions

Domain9 – 199191Lon
Nucleotide binding356 – 3638ATP By similarity

Sites

Active site6791 By similarity
Active site7221 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43864 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9E590852611EEA5B

FASTA80389,347
        10         20         30         40         50         60 
MAKNTQRTMP VLPLRDVVVF PYMVMPLFVG RAKSINALEE AMNDDKQILL VSQREADLEE 

        70         80         90        100        110        120 
PTPEDLFDVG TIANIIQLLK LPDDTVKVLV EGQNRAKINS LEDGEKCFSA QITPIETTYG 

       130        140        150        160        170        180 
DEKELVVAKS AVLSEFENYL TLNKKVPTDI LNALQRIDDV DRLADTMAAH LPVSIRHKQN 

       190        200        210        220        230        240 
ALELANVQER LEYLLGMMES EADILQVEKR IRGRVKKQME KSQRNYYLNE QIKAIRKEMD 

       250        260        270        280        290        300 
GGENEDTIDE VEQLHQKVEA AGMPADVRDK VENELQKLKM MSAMSSEATV IRSYIEWMIQ 

       310        320        330        340        350        360 
VPWHQRSKVK KDIVKAQQVL DTDHYGLDRV KERILEYLAV QARLNKVKGP ILCLVGPPGV 

       370        380        390        400        410        420 
GKTSLGQSIA NATGRKYVRM ALGGVRDEAE IRGHRKTYIG ALPGKLIQKM AKVGVKNPLF 

       430        440        450        460        470        480 
LLDEIDKMAS DMRGDPASAL LEVLDPEQNT TFNDHYLEVD YDLSDVMFVA TSNSMNIPGP 

       490        500        510        520        530        540 
LLDRMEVIRL SGYTEDEKLN IAMRHLLAKQ IERNGLKKGE LTVEESAILD IIRYYTREAG 

       550        560        570        580        590        600 
VRGLEREISK ICRKAVKNLL VNPKLKSITV NSDNLHDYLG VKRFEFGKAD TQNRIGEVTG 

       610        620        630        640        650        660 
LAWTEVGGDL LTIETASVVG KGKLSFTGSL GDVMKESIQA AMTVVRARAD KLGINAEFHE 

       670        680        690        700        710        720 
KRDIHIHVPD GATPKDGPSA GIAMCTALIS CLTGNPVRAD VAMTGEISLR GKVLPIGGLK 

       730        740        750        760        770        780 
EKLLAAHRGG IKTVLIPKEN VKDLEEIPEN VKQNLAIHAV ETIDEVLGFA LENPPEGIEF 

       790        800 
VKVEAKPKAP RRKVTSKSER AVN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22121.1.
PIRA64070.
RefSeqNP_438623.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43864.
SMRP43864. Positions 9-111, 491-584, 594-781.
ModBaseSearch...

Protein family/group databases

MEROPSS16.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949549.
GenomeReviewsGene locus HI_0462 in contig L42023_GR.
KEGGhin:HI0462.
NMPDRfig|71421.1.peg.436.
PATRIC20189479. VBIHaeInf48452_0482.
TIGRHI_0462.

Phylogenomic databases

HOGENOMHBG566281.
OMAFMEGEIS.
PhylomeDBP43864.
ProtClustDBCLSK870682.

Enzyme and pathway databases

BioCycHINF71421:HI_0462-MONOMER.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
KOK01338.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00763. Lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_HAEIN
AccessionPrimary (citable) accession number: P43864
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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