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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Putative anthranilate synthase component II (HI_1171), Anthranilate synthase component 2 (trpG), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei81Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei89PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi93Magnesium 1UniRule annotation1
Binding sitei112Anthranilate 1UniRule annotation1
Binding sitei121Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei167Anthranilate 2UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1
Metal bindingi226Magnesium 1UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:HI_1389
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001544481 – 333Anthranilate phosphoribosyltransferaseAdd BLAST333

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1389.

Structurei

3D structure databases

ProteinModelPortaliP43858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni91 – 94Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni109 – 117Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYG. Bacteria.
COG0547. LUCA.
KOiK00766.
OMAiMIVLNAG.
PhylomeDBiP43858.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

P43858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHNQLLEQL YSGHSLSTSE STALFNAVIQ GELSNEQIAA MLIALKVRGA
60 70 80 90 100
NTEEISGAVA ASLQNAKAFP YPNYPFADIV GTGGNGQNTI NISTTSAIVA
110 120 130 140 150
ASMGAKIAKH GNRSVSSKSG ASDVLTALSV NVNVTPEQAR QALDEIGVCF
160 170 180 190 200
LFAQQYHSGF RHVAPVRAAL KTRTIFNILG PLINPARPTY HLLGVYAPEL
210 220 230 240 250
VKTYAETAVA LEHQHSFVVH GSGLDEVALH GETQVAEIKN GKIEYFTLTP
260 270 280 290 300
EDFGLKTQSL ESLRGGEPQE NAQYLTALLQ GKGKAEHANA VAANTALLLK
310 320 330
LFGYDDLKQN VQNVLAHLVS GKAFETLQKL TTY
Length:333
Mass (Da):35,625
Last modified:November 1, 1995 - v1
Checksum:i80BFF7676E0494B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23035.1.
PIRiE64121.
RefSeqiNP_439542.1. NC_000907.1.
WP_005693973.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23035; AAC23035; HI_1389.
GeneIDi950894.
KEGGihin:HI1389.
PATRICi20191473. VBIHaeInf48452_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23035.1.
PIRiE64121.
RefSeqiNP_439542.1. NC_000907.1.
WP_005693973.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23035; AAC23035; HI_1389.
GeneIDi950894.
KEGGihin:HI1389.
PATRICi20191473. VBIHaeInf48452_1447.

Phylogenomic databases

eggNOGiENOG4107QYG. Bacteria.
COG0547. LUCA.
KOiK00766.
OMAiMIVLNAG.
PhylomeDBiP43858.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_HAEIN
AccessioniPrimary (citable) accession number: P43858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.