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P43854

- PUR1_HAEIN

UniProt

P43854 - PUR1_HAEIN

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Protein

Amidophosphoribosyltransferase

Gene

purF

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.UniRule annotation

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21NucleophileUniRule annotation
Metal bindingi306 – 3061MagnesiumUniRule annotation
Metal bindingi368 – 3681MagnesiumUniRule annotation
Metal bindingi369 – 3691MagnesiumUniRule annotation

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
  3. nucleoside metabolic process Source: InterPro
  4. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
Short name:
GPATaseUniRule annotation
Gene namesi
Name:purFUniRule annotation
Ordered Locus Names:HI_1207
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 505504AmidophosphoribosyltransferasePRO_0000139639Add
BLAST

Proteomic databases

PRIDEiP43854.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1207.

Structurei

3D structure databases

ProteinModelPortaliP43854.
SMRiP43854. Positions 2-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 235234Glutamine amidotransferase type-2UniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation
Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0034.
KOiK00764.
OMAiAARVHMG.
OrthoDBiEOG6KT2Q1.
PhylomeDBiP43854.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01931. PurF.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43854-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGIVSQ SPVNESIYAA LTLLQHRGQD AAGIVTVDDE NRFRLRKANG
60 70 80 90 100
LVSDVFHQEH MLRLQGNAGL GHVRYPTAGS SSVSEAQPFY VNSPYGVTLV
110 120 130 140 150
HNGNLTNSVE LKEKVFKTAR RHVNTNSDSE LLLNILANHL DHIPQDHLDP
160 170 180 190 200
QDIFYAVRKT HKDVRGAYAC LAMIIGHGMV AFRDPFGIRP LVLGKREENG
210 220 230 240 250
KTDYMFASET VALDIVGFEF VRDIAAGEAV YVTFDGELYS QQCAESAVLN
260 270 280 290 300
PCIFEYVYFA RPDSTIDGVS VYAARVHMGE KLGQKIAKEW ADEIDNIDVV
310 320 330 340 350
IPVPETSTDI ALQIARVLGK PYRQGFVKNR YVGRTFIMPG QAQRISSVRR
360 370 380 390 400
KLNTIKAEFK DKNVLLVDDS IVRGTTSEQI VEMARSAGAK KIYFASAAPE
410 420 430 440 450
IRYPNVYGID MPSRDELIAY GRNVDEIAEL IGVDKLIFQD LTALTESVQL
460 470 480 490 500
ENPAIQGFDC SVFTGEYITG DISPEYLEKI ATQRNDNAKK KREKQASNLE

IYNEQ
Length:505
Mass (Da):56,206
Last modified:January 23, 2007 - v2
Checksum:iCD665BB22EB88E22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22861.1.
PIRiI64189.
RefSeqiNP_439363.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22861; AAC22861; HI_1207.
GeneIDi950171.
KEGGihin:HI1207.
PATRICi20191093. VBIHaeInf48452_1259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22861.1 .
PIRi I64189.
RefSeqi NP_439363.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43854.
SMRi P43854. Positions 2-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1207.

Protein family/group databases

MEROPSi C44.001.

Proteomic databases

PRIDEi P43854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22861 ; AAC22861 ; HI_1207 .
GeneIDi 950171.
KEGGi hin:HI1207.
PATRICi 20191093. VBIHaeInf48452_1259.

Phylogenomic databases

eggNOGi COG0034.
KOi K00764.
OMAi AARVHMG.
OrthoDBi EOG6KT2Q1.
PhylomeDBi P43854.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
HAMAPi MF_01931. PurF.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPUR1_HAEIN
AccessioniPrimary (citable) accession number: P43854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3