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P43854 (PUR1_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase

Short name=ATase
EC=2.4.2.14
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Short name=GPATase
Gene names
Name:purF
Ordered Locus Names:HI_1207
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.

Cofactor

Binds 1 magnesium ion per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Contains 1 glutamine amidotransferase type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 505504Amidophosphoribosyltransferase
PRO_0000139639

Regions

Domain2 – 235234Glutamine amidotransferase type-2

Sites

Active site21For GATase activity
Metal binding3681Magnesium By similarity
Metal binding3691Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P43854 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CD665BB22EB88E22

FASTA50556,206
        10         20         30         40         50         60 
MCGIVGIVSQ SPVNESIYAA LTLLQHRGQD AAGIVTVDDE NRFRLRKANG LVSDVFHQEH 

        70         80         90        100        110        120 
MLRLQGNAGL GHVRYPTAGS SSVSEAQPFY VNSPYGVTLV HNGNLTNSVE LKEKVFKTAR 

       130        140        150        160        170        180 
RHVNTNSDSE LLLNILANHL DHIPQDHLDP QDIFYAVRKT HKDVRGAYAC LAMIIGHGMV 

       190        200        210        220        230        240 
AFRDPFGIRP LVLGKREENG KTDYMFASET VALDIVGFEF VRDIAAGEAV YVTFDGELYS 

       250        260        270        280        290        300 
QQCAESAVLN PCIFEYVYFA RPDSTIDGVS VYAARVHMGE KLGQKIAKEW ADEIDNIDVV 

       310        320        330        340        350        360 
IPVPETSTDI ALQIARVLGK PYRQGFVKNR YVGRTFIMPG QAQRISSVRR KLNTIKAEFK 

       370        380        390        400        410        420 
DKNVLLVDDS IVRGTTSEQI VEMARSAGAK KIYFASAAPE IRYPNVYGID MPSRDELIAY 

       430        440        450        460        470        480 
GRNVDEIAEL IGVDKLIFQD LTALTESVQL ENPAIQGFDC SVFTGEYITG DISPEYLEKI 

       490        500 
ATQRNDNAKK KREKQASNLE IYNEQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22861.1.
PIRI64189.
RefSeqNP_439363.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43854.
SMRP43854. Positions 2-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1207.

Protein family/group databases

MEROPSC44.001.

Proteomic databases

PRIDEP43854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22861; AAC22861; HI_1207.
GeneID950171.
KEGGhin:HI1207.
PATRIC20191093. VBIHaeInf48452_1259.

Phylogenomic databases

eggNOGCOG0034.
KOK00764.
OMACDACFTG.
OrthoDBEOG6KT2Q1.
ProtClustDBPRK09246.

Enzyme and pathway databases

UniPathwayUPA00074; UER00124.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. purF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR1_HAEIN
AccessionPrimary (citable) accession number: P43854
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names