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P43853

- HIS1_HAEIN

UniProt

P43853 - HIS1_HAEIN

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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Magnesium.By similarity

Enzyme regulationi

Feedback inhibited by histidine.By similarity

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:HI_0468
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303ATP phosphoribosyltransferasePRO_0000151852Add
BLAST

Proteomic databases

PRIDEiP43853.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0468.

Structurei

3D structure databases

ProteinModelPortaliP43853.
SMRiP43853. Positions 10-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0040.
KOiK00765.
OMAiTRMQGVI.
OrthoDBiEOG66MQT3.
PhylomeDBiP43853.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNTTMQPNR LRIALQKKGR LSQDCAILLK QCGVKINWNE QRLIAYAENL
60 70 80 90 100
PIEILRVRDD DIPGLIFDGV VDLGIIGENV LEEEELGRRA ANETVTYKKL
110 120 130 140 150
RQLDFGDCRL SLAVDRDCHY ENVKDLANRR IATSYPHLLK RYMNENGVSF
160 170 180 190 200
KSCLLNGSVE VAPSAGIAYA ICDLVSSGAT LEANGLKEVD VIYRSKACLI
210 220 230 240 250
QRAEPLESTK QALVDKLLTR IQGVQQAAES KYIMLHAPKE KLEKITALLP
260 270 280 290 300
GVENPTILPL ASDTTRVAMH VVSQENLFWE TMEQLKEAGA SSILVLPIEK

MME
Length:303
Mass (Da):33,821
Last modified:November 1, 1995 - v1
Checksum:i08C14D1F6E98A31D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22127.1.
PIRiD64070.
RefSeqiNP_438629.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22127; AAC22127; HI_0468.
GeneIDi949555.
KEGGihin:HI0468.
PATRICi20189491. VBIHaeInf48452_0488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22127.1 .
PIRi D64070.
RefSeqi NP_438629.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43853.
SMRi P43853. Positions 10-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0468.

Proteomic databases

PRIDEi P43853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22127 ; AAC22127 ; HI_0468 .
GeneIDi 949555.
KEGGi hin:HI0468.
PATRICi 20189491. VBIHaeInf48452_0488.

Phylogenomic databases

eggNOGi COG0040.
KOi K00765.
OMAi TRMQGVI.
OrthoDBi EOG66MQT3.
PhylomeDBi P43853.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
HAMAPi MF_00079. HisG_Long.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
TIGRFAMsi TIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiHIS1_HAEIN
AccessioniPrimary (citable) accession number: P43853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3