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P43853

- HIS1_HAEIN

UniProt

P43853 - HIS1_HAEIN

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.By similarity

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Feedback inhibited by histidine.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferase (EC:2.4.2.17)
    Short name:
    ATP-PRT
    Short name:
    ATP-PRTase
    Gene namesi
    Name:hisG
    Ordered Locus Names:HI_0468
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303ATP phosphoribosyltransferasePRO_0000151852Add
    BLAST

    Proteomic databases

    PRIDEiP43853.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0468.

    Structurei

    3D structure databases

    ProteinModelPortaliP43853.
    SMRiP43853. Positions 10-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0040.
    KOiK00765.
    OMAiTRMQGVI.
    OrthoDBiEOG66MQT3.
    PhylomeDBiP43853.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNTTMQPNR LRIALQKKGR LSQDCAILLK QCGVKINWNE QRLIAYAENL    50
    PIEILRVRDD DIPGLIFDGV VDLGIIGENV LEEEELGRRA ANETVTYKKL 100
    RQLDFGDCRL SLAVDRDCHY ENVKDLANRR IATSYPHLLK RYMNENGVSF 150
    KSCLLNGSVE VAPSAGIAYA ICDLVSSGAT LEANGLKEVD VIYRSKACLI 200
    QRAEPLESTK QALVDKLLTR IQGVQQAAES KYIMLHAPKE KLEKITALLP 250
    GVENPTILPL ASDTTRVAMH VVSQENLFWE TMEQLKEAGA SSILVLPIEK 300
    MME 303
    Length:303
    Mass (Da):33,821
    Last modified:November 1, 1995 - v1
    Checksum:i08C14D1F6E98A31D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22127.1.
    PIRiD64070.
    RefSeqiNP_438629.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22127; AAC22127; HI_0468.
    GeneIDi949555.
    KEGGihin:HI0468.
    PATRICi20189491. VBIHaeInf48452_0488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22127.1 .
    PIRi D64070.
    RefSeqi NP_438629.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43853.
    SMRi P43853. Positions 10-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0468.

    Proteomic databases

    PRIDEi P43853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22127 ; AAC22127 ; HI_0468 .
    GeneIDi 949555.
    KEGGi hin:HI0468.
    PATRICi 20189491. VBIHaeInf48452_0488.

    Phylogenomic databases

    eggNOGi COG0040.
    KOi K00765.
    OMAi TRMQGVI.
    OrthoDBi EOG66MQT3.
    PhylomeDBi P43853.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiHIS1_HAEIN
    AccessioniPrimary (citable) accession number: P43853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3