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P43852

- PUR9_HAEIN

UniProt

P43852 - PUR9_HAEIN

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:HI_0887
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Bifunctional purine biosynthesis protein PurHPRO_0000192095Add
    BLAST

    Proteomic databases

    PRIDEiP43852.

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0887.

    Structurei

    3D structure databases

    ProteinModelPortaliP43852.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.
    PhylomeDBiP43852.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43852-1 [UniParc]FASTAAdd to Basket

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    MADRPIRQAL LSVSDKTGIV EFAQGLVKRG VKLLSTGGTA KLLAQNALPV    50
    IEVSDYTGFP EMMDGRVKTL HPKVHGGILG RRGTDDAIMQ QHGIEGIDMV 100
    VVNLYPFAAT VAKPDCTLAD AVENIDIGGP TMVRSAAKNH KDVAIVVNNH 150
    DFNAILAEMD QHQNSLTFET RFDLAIKAFE HTAQYDSMIA NYFGQLVKPY 200
    HIAEEEEANA KCGQFPRTLN LNFVRKQAMR YGENSHQNAA FYVDLNVKEA 250
    SVATANQLQG KALSYNNIAD TDAALECVKE FDDPACVIVK HANPCGVALG 300
    KDILDAYNRA YQTDPTSAFG GIIAFNRELD EKTANEIVER QFVEVIIAPK 350
    VSAEAQEVMK RKKNVRLLEC GEWTSRSERL DFKRVNGGLL VQDADLGMVG 400
    VDDLKVVSKR QPTEQELKDL LFCWKVAKFV KSNAIVYAKD NQTIGIGAGQ 450
    MSRVYSAKIA GIKAQDEGLE VAGCVMASDA FFPFRDGIDA AAKVGIQCVI 500
    HPGGSMRDQE VIDAADEHNM VMVLTGMRHF RH 532
    Length:532
    Mass (Da):58,350
    Last modified:November 1, 1995 - v1
    Checksum:i9DE1E241DD238E87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22544.1.
    PIRiB64100.
    RefSeqiNP_439048.1. NC_000907.1.
    WP_005693238.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22544; AAC22544; HI_0887.
    GeneIDi949891.
    KEGGihin:HI0887.
    PATRICi20190431. VBIHaeInf48452_0929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22544.1 .
    PIRi B64100.
    RefSeqi NP_439048.1. NC_000907.1.
    WP_005693238.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43852.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0887.

    Proteomic databases

    PRIDEi P43852.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22544 ; AAC22544 ; HI_0887 .
    GeneIDi 949891.
    KEGGi hin:HI0887.
    PATRICi 20190431. VBIHaeInf48452_0929.

    Phylogenomic databases

    eggNOGi COG0138.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.
    PhylomeDBi P43852.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPUR9_HAEIN
    AccessioniPrimary (citable) accession number: P43852
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3