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P43852

- PUR9_HAEIN

UniProt

P43852 - PUR9_HAEIN

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, HI_0887
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:HI_0887
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192095Add
BLAST

Proteomic databases

PRIDEiP43852.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0887.

Structurei

3D structure databases

ProteinModelPortaliP43852.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiP43852.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P43852-1 [UniParc]FASTAAdd to Basket

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MADRPIRQAL LSVSDKTGIV EFAQGLVKRG VKLLSTGGTA KLLAQNALPV    50
IEVSDYTGFP EMMDGRVKTL HPKVHGGILG RRGTDDAIMQ QHGIEGIDMV 100
VVNLYPFAAT VAKPDCTLAD AVENIDIGGP TMVRSAAKNH KDVAIVVNNH 150
DFNAILAEMD QHQNSLTFET RFDLAIKAFE HTAQYDSMIA NYFGQLVKPY 200
HIAEEEEANA KCGQFPRTLN LNFVRKQAMR YGENSHQNAA FYVDLNVKEA 250
SVATANQLQG KALSYNNIAD TDAALECVKE FDDPACVIVK HANPCGVALG 300
KDILDAYNRA YQTDPTSAFG GIIAFNRELD EKTANEIVER QFVEVIIAPK 350
VSAEAQEVMK RKKNVRLLEC GEWTSRSERL DFKRVNGGLL VQDADLGMVG 400
VDDLKVVSKR QPTEQELKDL LFCWKVAKFV KSNAIVYAKD NQTIGIGAGQ 450
MSRVYSAKIA GIKAQDEGLE VAGCVMASDA FFPFRDGIDA AAKVGIQCVI 500
HPGGSMRDQE VIDAADEHNM VMVLTGMRHF RH 532
Length:532
Mass (Da):58,350
Last modified:November 1, 1995 - v1
Checksum:i9DE1E241DD238E87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22544.1.
PIRiB64100.
RefSeqiNP_439048.1. NC_000907.1.
WP_005693238.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22544; AAC22544; HI_0887.
GeneIDi949891.
KEGGihin:HI0887.
PATRICi20190431. VBIHaeInf48452_0929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22544.1 .
PIRi B64100.
RefSeqi NP_439048.1. NC_000907.1.
WP_005693238.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43852.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0887.

Proteomic databases

PRIDEi P43852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22544 ; AAC22544 ; HI_0887 .
GeneIDi 949891.
KEGGi hin:HI0887.
PATRICi 20190431. VBIHaeInf48452_0929.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi P43852.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPUR9_HAEIN
AccessioniPrimary (citable) accession number: P43852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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