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P43852 (PUR9_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:HI_0887
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192095

Sequences

Sequence LengthMass (Da)Tools
P43852 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9DE1E241DD238E87

FASTA53258,350
        10         20         30         40         50         60 
MADRPIRQAL LSVSDKTGIV EFAQGLVKRG VKLLSTGGTA KLLAQNALPV IEVSDYTGFP 

        70         80         90        100        110        120 
EMMDGRVKTL HPKVHGGILG RRGTDDAIMQ QHGIEGIDMV VVNLYPFAAT VAKPDCTLAD 

       130        140        150        160        170        180 
AVENIDIGGP TMVRSAAKNH KDVAIVVNNH DFNAILAEMD QHQNSLTFET RFDLAIKAFE 

       190        200        210        220        230        240 
HTAQYDSMIA NYFGQLVKPY HIAEEEEANA KCGQFPRTLN LNFVRKQAMR YGENSHQNAA 

       250        260        270        280        290        300 
FYVDLNVKEA SVATANQLQG KALSYNNIAD TDAALECVKE FDDPACVIVK HANPCGVALG 

       310        320        330        340        350        360 
KDILDAYNRA YQTDPTSAFG GIIAFNRELD EKTANEIVER QFVEVIIAPK VSAEAQEVMK 

       370        380        390        400        410        420 
RKKNVRLLEC GEWTSRSERL DFKRVNGGLL VQDADLGMVG VDDLKVVSKR QPTEQELKDL 

       430        440        450        460        470        480 
LFCWKVAKFV KSNAIVYAKD NQTIGIGAGQ MSRVYSAKIA GIKAQDEGLE VAGCVMASDA 

       490        500        510        520        530 
FFPFRDGIDA AAKVGIQCVI HPGGSMRDQE VIDAADEHNM VMVLTGMRHF RH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22544.1.
PIRB64100.
RefSeqNP_439048.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43852.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0887.

Proteomic databases

PRIDEP43852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22544; AAC22544; HI_0887.
GeneID949891.
KEGGhin:HI0887.
PATRIC20190431. VBIHaeInf48452_0929.

Phylogenomic databases

eggNOGCOG0138.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.
PhylomeDBP43852.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_HAEIN
AccessionPrimary (citable) accession number: P43852
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names