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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-927-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:HI_0887
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001920951 – 532Bifunctional purine biosynthesis protein PurHAdd BLAST532

Proteomic databases

PRIDEiP43852.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0887.

Structurei

3D structure databases

ProteinModelPortaliP43852.
SMRiP43852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 147MGS-likePROSITE-ProRule annotationAdd BLAST147

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105DC1. Bacteria.
COG0138. LUCA.
KOiK00602.
OMAiDLLFAWK.
PhylomeDBiP43852.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH. 1 hit.
InterProiView protein in InterPro
IPR024051. AICAR_Tfase_dup_dom_sf.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
IPR036914. MGS-like_dom_sf.
IPR002695. PurH-like.
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiView protein in Pfam
PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiView protein in SMART
SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.
PROSITEiView protein in PROSITE
PS51855. MGS. 1 hit.

Sequencei

Sequence statusi: Complete.

P43852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRPIRQAL LSVSDKTGIV EFAQGLVKRG VKLLSTGGTA KLLAQNALPV
60 70 80 90 100
IEVSDYTGFP EMMDGRVKTL HPKVHGGILG RRGTDDAIMQ QHGIEGIDMV
110 120 130 140 150
VVNLYPFAAT VAKPDCTLAD AVENIDIGGP TMVRSAAKNH KDVAIVVNNH
160 170 180 190 200
DFNAILAEMD QHQNSLTFET RFDLAIKAFE HTAQYDSMIA NYFGQLVKPY
210 220 230 240 250
HIAEEEEANA KCGQFPRTLN LNFVRKQAMR YGENSHQNAA FYVDLNVKEA
260 270 280 290 300
SVATANQLQG KALSYNNIAD TDAALECVKE FDDPACVIVK HANPCGVALG
310 320 330 340 350
KDILDAYNRA YQTDPTSAFG GIIAFNRELD EKTANEIVER QFVEVIIAPK
360 370 380 390 400
VSAEAQEVMK RKKNVRLLEC GEWTSRSERL DFKRVNGGLL VQDADLGMVG
410 420 430 440 450
VDDLKVVSKR QPTEQELKDL LFCWKVAKFV KSNAIVYAKD NQTIGIGAGQ
460 470 480 490 500
MSRVYSAKIA GIKAQDEGLE VAGCVMASDA FFPFRDGIDA AAKVGIQCVI
510 520 530
HPGGSMRDQE VIDAADEHNM VMVLTGMRHF RH
Length:532
Mass (Da):58,350
Last modified:November 1, 1995 - v1
Checksum:i9DE1E241DD238E87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22544.1.
PIRiB64100.
RefSeqiNP_439048.1. NC_000907.1.
WP_005693238.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22544; AAC22544; HI_0887.
GeneIDi949891.
KEGGihin:HI0887.
PATRICifig|71421.8.peg.929.

Similar proteinsi

Entry informationi

Entry nameiPUR9_HAEIN
AccessioniPrimary (citable) accession number: P43852
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome