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P43850 (PURK_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide synthase
Short name=N5-CAIR synthase
EC=6.3.4.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene names
Name:purK
Ordered Locus Names:HI_1616
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PurK/PurT family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362N5-carboxyaminoimidazole ribonucleotide synthase
PRO_0000074998

Regions

Domain89 – 274186ATP-grasp
Nucleotide binding158 – 1614ATP By similarity
Nucleotide binding244 – 2452ATP By similarity

Sites

Binding site851ATP By similarity
Binding site1251ATP By similarity
Binding site1361ATP By similarity
Binding site1661ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P43850 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 90CE70504784B452

FASTA36241,273
        10         20         30         40         50         60 
MQNSTLYPTV YVLGNGQLGR MLRYAGAPLD IYVEPLAFNA PVFDLPENAI ITAEIERWEK 

        70         80         90        100        110        120 
TPLTELLGNH KNFVNQHIFG LLADRFTQKS LLDELNLSTS PWCLLKDKNQ WNDLFQTVGE 

       130        140        150        160        170        180 
KVVVKRRTGG YDGRGQWIIR DENRADITDD LFGEVIAEKF IPFDYEVSIV GARFKNGEKR 

       190        200        210        220        230        240 
FYPVTHNLQQ NGILRYSVVD CAFPQQSVQQ KQAETMLGKI MDKLGYVGVM AMECFVVGDK 

       250        260        270        280        290        300 
LLINELAPRV HNSGHWTQLG CSISQFELHL RALLNLPTPE LQTFAPSVMI NLIGTNHNPK 

       310        320        330        340        350        360 
WLNIPFAQLH WYGKEVRIGR KVGHINLSHP NKAVIIQQLE KLCTELPEDY QSGLNWAIEK 


LK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23264.1.
PIRH64132.
RefSeqNP_439758.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43850.
ModBaseSearch...

Protein-protein interaction databases

STRING71421.HI1616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23264; AAC23264; HI_1616.
GeneID950468.
KEGGhin:HI1616.
PATRIC20191963. VBIHaeInf48452_1689.

Phylogenomic databases

eggNOGCOG0026.
KOK01589.
OMAHWYEKEV.
ProtClustDBPRK06019.

Enzyme and pathway databases

UniPathwayUPA00074; UER00942.

Family and domain databases

Gene3D3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01161. purK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURK_HAEIN
AccessionPrimary (citable) accession number: P43850
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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