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P43850

- PURK_HAEIN

UniProt

P43850 - PURK_HAEIN

Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

purK

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).By similarity

    Catalytic activityi

    ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851ATPBy similarity
    Binding sitei125 – 1251ATPBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei166 – 1661ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi158 – 1614ATPPROSITE-ProRule annotation
    Nucleotide bindingi244 – 2452ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: InterPro
    4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00942.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N5-carboxyaminoimidazole ribonucleotide synthase (EC:6.3.4.18)
    Short name:
    N5-CAIR synthase
    Alternative name(s):
    5-(carboxyamino)imidazole ribonucleotide synthetase
    Gene namesi
    Name:purK
    Ordered Locus Names:HI_1616
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362N5-carboxyaminoimidazole ribonucleotide synthasePRO_0000074998Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1616.

    Structurei

    3D structure databases

    ProteinModelPortaliP43850.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 274186ATP-graspPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PurK/PurT family.Curated
    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0026.
    KOiK01589.
    OMAiIAPAHIT.
    OrthoDBiEOG6QZMX7.
    PhylomeDBiP43850.

    Family and domain databases

    Gene3Di3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02222. ATP-grasp. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01161. purK. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43850-1 [UniParc]FASTAAdd to Basket

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    MQNSTLYPTV YVLGNGQLGR MLRYAGAPLD IYVEPLAFNA PVFDLPENAI    50
    ITAEIERWEK TPLTELLGNH KNFVNQHIFG LLADRFTQKS LLDELNLSTS 100
    PWCLLKDKNQ WNDLFQTVGE KVVVKRRTGG YDGRGQWIIR DENRADITDD 150
    LFGEVIAEKF IPFDYEVSIV GARFKNGEKR FYPVTHNLQQ NGILRYSVVD 200
    CAFPQQSVQQ KQAETMLGKI MDKLGYVGVM AMECFVVGDK LLINELAPRV 250
    HNSGHWTQLG CSISQFELHL RALLNLPTPE LQTFAPSVMI NLIGTNHNPK 300
    WLNIPFAQLH WYGKEVRIGR KVGHINLSHP NKAVIIQQLE KLCTELPEDY 350
    QSGLNWAIEK LK 362
    Length:362
    Mass (Da):41,273
    Last modified:November 1, 1995 - v1
    Checksum:i90CE70504784B452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23264.1.
    PIRiH64132.
    RefSeqiNP_439758.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23264; AAC23264; HI_1616.
    GeneIDi950468.
    KEGGihin:HI1616.
    PATRICi20191963. VBIHaeInf48452_1689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23264.1 .
    PIRi H64132.
    RefSeqi NP_439758.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43850.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1616.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23264 ; AAC23264 ; HI_1616 .
    GeneIDi 950468.
    KEGGi hin:HI1616.
    PATRICi 20191963. VBIHaeInf48452_1689.

    Phylogenomic databases

    eggNOGi COG0026.
    KOi K01589.
    OMAi IAPAHIT.
    OrthoDBi EOG6QZMX7.
    PhylomeDBi P43850.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00942 .

    Family and domain databases

    Gene3Di 3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02222. ATP-grasp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01161. purK. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPURK_HAEIN
    AccessioniPrimary (citable) accession number: P43850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3