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P43850

- PURK_HAEIN

UniProt

P43850 - PURK_HAEIN

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene
purK, HI_1616
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATP By similarity
Binding sitei125 – 1251ATP By similarity
Binding sitei136 – 1361ATP By similarity
Binding sitei166 – 1661ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1614ATP By similarity
Nucleotide bindingi244 – 2452ATP By similarity

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthase (EC:6.3.4.18)
Short name:
N5-CAIR synthase
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene namesi
Name:purK
Ordered Locus Names:HI_1616
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362N5-carboxyaminoimidazole ribonucleotide synthasePRO_0000074998Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi71421.HI1616.

Structurei

3D structure databases

ProteinModelPortaliP43850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 274186ATP-graspAdd
BLAST

Sequence similaritiesi

Belongs to the PurK/PurT family.
Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0026.
KOiK01589.
OMAiIAPAHIT.
OrthoDBiEOG6QZMX7.
PhylomeDBiP43850.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43850-1 [UniParc]FASTAAdd to Basket

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MQNSTLYPTV YVLGNGQLGR MLRYAGAPLD IYVEPLAFNA PVFDLPENAI    50
ITAEIERWEK TPLTELLGNH KNFVNQHIFG LLADRFTQKS LLDELNLSTS 100
PWCLLKDKNQ WNDLFQTVGE KVVVKRRTGG YDGRGQWIIR DENRADITDD 150
LFGEVIAEKF IPFDYEVSIV GARFKNGEKR FYPVTHNLQQ NGILRYSVVD 200
CAFPQQSVQQ KQAETMLGKI MDKLGYVGVM AMECFVVGDK LLINELAPRV 250
HNSGHWTQLG CSISQFELHL RALLNLPTPE LQTFAPSVMI NLIGTNHNPK 300
WLNIPFAQLH WYGKEVRIGR KVGHINLSHP NKAVIIQQLE KLCTELPEDY 350
QSGLNWAIEK LK 362
Length:362
Mass (Da):41,273
Last modified:November 1, 1995 - v1
Checksum:i90CE70504784B452
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23264.1.
PIRiH64132.
RefSeqiNP_439758.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23264; AAC23264; HI_1616.
GeneIDi950468.
KEGGihin:HI1616.
PATRICi20191963. VBIHaeInf48452_1689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23264.1 .
PIRi H64132.
RefSeqi NP_439758.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43850.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23264 ; AAC23264 ; HI_1616 .
GeneIDi 950468.
KEGGi hin:HI1616.
PATRICi 20191963. VBIHaeInf48452_1689.

Phylogenomic databases

eggNOGi COG0026.
KOi K01589.
OMAi IAPAHIT.
OrthoDBi EOG6QZMX7.
PhylomeDBi P43850.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .

Family and domain databases

Gene3Di 3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPURK_HAEIN
AccessioniPrimary (citable) accession number: P43850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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