Reviewed, UniProtKB/Swiss-Prot P43849 (PUR6_HAEIN)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	HI1615

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074975
Sites
	Binding site	13	1	Substrate By similarity
	Binding site	16	1	Substrate By similarity
	Binding site	43	1	Substrate By similarity
Experimental info
	Sequence conflict	139 – 143	5	DALFT → AELLS in CAA83909. Ref.2
	Sequence conflict	147	1	A → S in CAA83909. Ref.2
	Sequence conflict	151	1	N → S in CAA83909. Ref.2
	Sequence conflict	154 – 155	2	NM → RA in CAA83909. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P43849-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 60A03B0D4DD85412	FASTA	164	17,269
	10 20 30 40 50 60 MSKTAQIAVV MGSKSDWATM QEATQILDEL NVPYHVEVVS AHRTPDKLFE FAENAQKNGY 70 80 90 100 110 120 KVIIAGAGGA AHLPGMIAAK TLVPVLGVPV KSSMLSGVDS LYSIVQMPKG IPVGTLAIGP 130 140 150 160 AGAANAGLLA AQILAGWDDA LFTRLQAFRE NQTNMVLDNP DPRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"The fimbrial gene cluster of Haemophilus influenzae type b." van Ham M.S., van Alphen L., Mooi F.R., van Putten J.P.M. Mol. Microbiol. 13:673-684(1994) [PubMed: 7997179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-161. Strain: AM30 (770235) / Serotype B.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC23263.1. Z33502 Genomic DNA. Translation: CAA83909.1.
PIR	G64132. S54434.
RefSeq	NP_439757.1.
3D structure databases
HSSP	HSSP built from PDB template 1QCZ based on UniProtKB P09028.
SMR	P43849. Positions 5-163.
ModBase	Search...
Genome annotation databases
GeneID	949616.
GenomeReviews	Gene locus HI1615 in contig L42023_GR.
KEGG	hin:HI1615.
NMPDR	fig|71421.1.peg.1531.
TIGR	HI1615.
Phylogenomic databases
HOGENOM	P43849.
OMA	GVVMGSS.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1615-MON.
BRENDA	4.1.1.21. 109.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_HAEIN

Accession

Primary (citable) accession number: P43849

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)