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P43848

- PUR5_HAEIN

UniProt

P43848 - PUR5_HAEIN

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
    Alternative name(s):
    AIR synthase
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    Gene namesi
    Name:purM
    Ordered Locus Names:HI_1429
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148215Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1429.

    Structurei

    3D structure databases

    ProteinModelPortaliP43848.
    SMRiP43848. Positions 4-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0150.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.
    PhylomeDBiP43848.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43848-1 [UniParc]FASTAAdd to Basket

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    MSNTQLSYKD AGVDIHTGNE LVERIKGDVK RTRRSEVMGG LGGFGALCAL    50
    PTKYKEPILV SGTDGVGTKL RLAIDLKKHD TIGQDLVAMC VNDLIVQGAE 100
    PLFFLDYYAT GKLDVDVAAS VIKGIADGCE MSGCALVGGE TAEMPGMYHE 150
    GDYDLAGFCV GVVEKSEIID GTAVKTGDTL IALGSSGAHS NGYSLIRKVL 200
    EVSGANPTDL LEGKPLSEHL LAPTKIYVKS ILQLIKQTEV HAIAHLTGGG 250
    FWENIPRVLP DNTKAVIDES SWQWPAIFNW LQEKGNISRY EMYRTFNCGV 300
    GMVIALPEKE VETALALLEQ SGEKAWVIGK IEHLGESEAQ VEIQ 344
    Length:344
    Mass (Da):37,066
    Last modified:November 1, 1995 - v1
    Checksum:i06EF6784D42A3936
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23076.1.
    PIRiG64122.
    RefSeqiNP_439578.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23076; AAC23076; HI_1429.
    GeneIDi950335.
    KEGGihin:HI1429.
    PATRICi20191553. VBIHaeInf48452_1486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23076.1 .
    PIRi G64122.
    RefSeqi NP_439578.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43848.
    SMRi P43848. Positions 4-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23076 ; AAC23076 ; HI_1429 .
    GeneIDi 950335.
    KEGGi hin:HI1429.
    PATRICi 20191553. VBIHaeInf48452_1486.

    Phylogenomic databases

    eggNOGi COG0150.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.
    PhylomeDBi P43848.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPUR5_HAEIN
    AccessioniPrimary (citable) accession number: P43848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3