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P43848

- PUR5_HAEIN

UniProt

P43848 - PUR5_HAEIN

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:HI_1429
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148215Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1429.

Structurei

3D structure databases

ProteinModelPortaliP43848.
SMRiP43848. Positions 4-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.Curated

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.
PhylomeDBiP43848.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

P43848-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTQLSYKD AGVDIHTGNE LVERIKGDVK RTRRSEVMGG LGGFGALCAL
60 70 80 90 100
PTKYKEPILV SGTDGVGTKL RLAIDLKKHD TIGQDLVAMC VNDLIVQGAE
110 120 130 140 150
PLFFLDYYAT GKLDVDVAAS VIKGIADGCE MSGCALVGGE TAEMPGMYHE
160 170 180 190 200
GDYDLAGFCV GVVEKSEIID GTAVKTGDTL IALGSSGAHS NGYSLIRKVL
210 220 230 240 250
EVSGANPTDL LEGKPLSEHL LAPTKIYVKS ILQLIKQTEV HAIAHLTGGG
260 270 280 290 300
FWENIPRVLP DNTKAVIDES SWQWPAIFNW LQEKGNISRY EMYRTFNCGV
310 320 330 340
GMVIALPEKE VETALALLEQ SGEKAWVIGK IEHLGESEAQ VEIQ
Length:344
Mass (Da):37,066
Last modified:November 1, 1995 - v1
Checksum:i06EF6784D42A3936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23076.1.
PIRiG64122.
RefSeqiNP_439578.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23076; AAC23076; HI_1429.
GeneIDi950335.
KEGGihin:HI1429.
PATRICi20191553. VBIHaeInf48452_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23076.1 .
PIRi G64122.
RefSeqi NP_439578.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43848.
SMRi P43848. Positions 4-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23076 ; AAC23076 ; HI_1429 .
GeneIDi 950335.
KEGGi hin:HI1429.
PATRICi 20191553. VBIHaeInf48452_1486.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.
PhylomeDBi P43848.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPUR5_HAEIN
AccessioniPrimary (citable) accession number: P43848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3