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P43848 (PUR5_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:HI_1429
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741_B

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741_B.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741_B
PRO_0000148215

Sequences

Sequence LengthMass (Da)Tools
P43848 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 06EF6784D42A3936

FASTA34437,066
        10         20         30         40         50         60 
MSNTQLSYKD AGVDIHTGNE LVERIKGDVK RTRRSEVMGG LGGFGALCAL PTKYKEPILV 

        70         80         90        100        110        120 
SGTDGVGTKL RLAIDLKKHD TIGQDLVAMC VNDLIVQGAE PLFFLDYYAT GKLDVDVAAS 

       130        140        150        160        170        180 
VIKGIADGCE MSGCALVGGE TAEMPGMYHE GDYDLAGFCV GVVEKSEIID GTAVKTGDTL 

       190        200        210        220        230        240 
IALGSSGAHS NGYSLIRKVL EVSGANPTDL LEGKPLSEHL LAPTKIYVKS ILQLIKQTEV 

       250        260        270        280        290        300 
HAIAHLTGGG FWENIPRVLP DNTKAVIDES SWQWPAIFNW LQEKGNISRY EMYRTFNCGV 

       310        320        330        340 
GMVIALPEKE VETALALLEQ SGEKAWVIGK IEHLGESEAQ VEIQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23076.1.
PIRG64122.
RefSeqNP_439578.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43848.
SMRP43848. Positions 4-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23076; AAC23076; HI_1429.
GeneID950335.
KEGGhin:HI1429.
PATRIC20191553. VBIHaeInf48452_1486.

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAIDMIAMN.
OrthoDBEOG61CM1V.
ProtClustDBPRK05385.

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_HAEIN
AccessionPrimary (citable) accession number: P43848
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names