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P43845 (PUR2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:HI_0888
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151452

Regions

Domain109 – 316208ATP-grasp
Nucleotide binding135 – 19662ATP By similarity

Sites

Metal binding2861Magnesium or manganese By similarity
Metal binding2881Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P43845 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3F31BC3B5B9D373B

FASTA42946,248
        10         20         30         40         50         60 
MNILIIGNGG REHALAWKVA QSPLADKVFV APGNAGTALE HKVENVNISA TDIPALVKFA 

        70         80         90        100        110        120 
QDKQIGLTIV GPEAPLVIGV VDAFREAGLK IFGPAKAAAQ LEGSKAFTKD FLARHKIPTA 

       130        140        150        160        170        180 
EYQNFTEVEP ALTYLREKGT PIVVKADGLA AGKGVIVAMT LQEAEDAVRD MLSGNAFGEA 

       190        200        210        220        230        240 
GSRVVIEEFL DGEEASFIVM VDGKNVEPMA SSQDHKRVGE NDTGLNTGGM GAYSPAPVIT 

       250        260        270        280        290        300 
PEIHSRIMKE VIYPTVNGMA AEGNVYTGFL YAGLMIMPNG QPKVIEFNCR FGDPETQPIM 

       310        320        330        340        350        360 
LRLKSDLVEL CLKACDGKLD EVISQWDLRA SLGIVLAAEG YPKDYRKGDE ISGLPKSAVK 

       370        380        390        400        410        420 
NEKVFLAGVA EQEGKLVTNG GRVLCVTALG ESVFEAQQKA LKLAEQIQWS GRFYRRDIGY 


RAVERELQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22545.1.
PIRC64100.
RefSeqNP_439049.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43845.
SMRP43845. Positions 1-425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0888.

Proteomic databases

PRIDEP43845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22545; AAC22545; HI_0888.
GeneID949893.
KEGGhin:HI0888.
PATRIC20190433. VBIHaeInf48452_0930.

Phylogenomic databases

eggNOGCOG0151.
KOK01945.
OMAYKGFLYA.
OrthoDBEOG69SKD1.
PhylomeDBP43845.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_HAEIN
AccessionPrimary (citable) accession number: P43845
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names