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Protein

NAD(P) transhydrogenase subunit alpha

Gene

pntA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.By similarity

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei175NAD; via amide nitrogenBy similarity1
Binding sitei225NAD; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 128NADBy similarity4
Nucleotide bindingi195 – 197NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1387-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit alpha (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit alpha
Pyridine nucleotide transhydrogenase subunit alpha
Gene namesi
Name:pntA
Ordered Locus Names:HI_1362
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 400CytoplasmicSequence analysisAdd BLAST400
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 451CytoplasmicSequence analysis9
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 478PeriplasmicSequence analysis6
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 512CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990181 – 512NAD(P) transhydrogenase subunit alphaAdd BLAST512

Proteomic databases

PRIDEiP43842

Interactioni

Subunit structurei

Heterodimer of an alpha (PntA) and a beta (PntB) chain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi71421.HI1362

Structurei

3D structure databases

ProteinModelPortaliP43842
SMRiP43842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AlaDH/PNT family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IIE Bacteria
COG3288 LUCA
KOiK00324
OMAiAKVFIMG
PhylomeDBiP43842

Family and domain databases

InterProiView protein in InterPro
IPR008143 Ala_DH/PNT_CS2
IPR008142 AlaDH/PNT_CS1
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR036291 NAD(P)-bd_dom_sf
IPR026255 NADP_transhyd_a
IPR024605 NADP_transhyd_a_C
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PF12769 PNTB_4TM, 1 hit
PIRSFiPIRSF000203 NADP_transhydrogenase_alpha, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SM01003 AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00561 pntA, 1 hit
PROSITEiView protein in PROSITE
PS00836 ALADH_PNT_1, 1 hit
PS00837 ALADH_PNT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIGVPRELL ENESRVAATP KTVQQILKLG FDVIVEHDAG FKASFEDQAF
60 70 80 90 100
LEAGAKIGTS AEIWQSDIIF KVNAPTDEEI AQMKEGAALV SFIWRMQNPE
110 120 130 140 150
LMKKLTAKKI NVLAMDAVPR ISRAQALDAL SSMANISGYR AVIEAAHEFG
160 170 180 190 200
SFFTGQITAA GKVPPAKVLV IGAGVAGLAA IGAANSLGAI VRAFDSRPEV
210 220 230 240 250
KEQVQSMGAS FLEIDFKEEG GSGDGYAKVM SEEFNRRAME LYAEQAKEVD
260 270 280 290 300
IIITTAAIPG KPAPRLITKE MVDSMKPGSV IVDLAAATGG NCEYTQAGKV
310 320 330 340 350
VTTENQVKVI GYTDFPSRLP TQSSQLYGTN LVNLLKLLCK EKDGNINIDF
360 370 380 390 400
EDVVLRGVTV VRDGEEIPPA QIQVSAQPKQ ETKAAPVAEK KESKPTDPRV
410 420 430 440 450
KYGVMAGVGV LFLWLASVAP AAFLSHFTVF VLACVVGYYV VWNVSHALHT
460 470 480 490 500
PLMAVTNAIS GIIIVGALLQ IRQPTGNLFI DALAFVAILV ASINIFGGFR
510
VTQRMLAMFR KG
Length:512
Mass (Da):54,973
Last modified:November 1, 1995 - v1
Checksum:i50D63AD536E837EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23009.1
PIRiE64119
RefSeqiNP_439513.1, NC_000907.1
WP_005693998.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23009; AAC23009; HI_1362
GeneIDi950278
KEGGihin:HI1362
PATRICifig|71421.8.peg.1416

Similar proteinsi

Entry informationi

Entry nameiPNTA_HAEIN
AccessioniPrimary (citable) accession number: P43842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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