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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:HI_1583
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Arginine--tRNA ligasePRO_0000151564Add
BLAST

Proteomic databases

PRIDEiP43832.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1583.

Structurei

3D structure databases

ProteinModelPortaliP43832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi122 – 13211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.
PhylomeDBiP43832.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQSILSDK IKQAMILAGA DQSCDALIRQ SGKPQFGDYQ ANGIMAAAKK
60 70 80 90 100
LGLNPREFAQ KVLDNLQLSD IAEKLEIAGP GFINIFLNPT WLTTEISAAL
110 120 130 140 150
SHKNLGIQAT NKQTVVIDYS SPNVAKEMHV GHLRSTIIGD AVARTLEFLG
160 170 180 190 200
HNVIRANHVG DWGTQFGMLI AYLEKMQNEH ASEMELQDLE AFYREAKKHY
210 220 230 240 250
DEDEVFAEKA RNYVVKLQSG DEYCRTMWKR LVDITMQQNQ HNYARLNVTL
260 270 280 290 300
TEKDVMGESL YNPMLPSIVK DLKKQGLAVE NDGALVVYLD EFKNKDGDPM
310 320 330 340 350
GVIVQKKDGG FLYTTTDIAA AKYRYETLKA NRALVFSDTR QSQHMQQAWL
360 370 380 390 400
ITRKAGYVPD SFSLEHKNFG MMLGKDGKPF KTRTGGTVKL ADLLDEAIER
410 420 430 440 450
ATVLINEKNT NLSNDEKEAV IEAVGIGAVK YADLSKNRTT DYVFDWDNML
460 470 480 490 500
SFEGNTAPYM QYAYTRIRSI FNKTDINSTA LLAAPLTIKD DKERTLAIKL
510 520 530 540 550
LQFEEAVQTV GKEGTPHVLC AYLYELAGIF SSFYEHCPIL NAEDESIKLS
560 570
RLKLALLTEK TLKQGLTLLG IKTVEKM
Length:577
Mass (Da):64,732
Last modified:November 1, 1995 - v1
Checksum:i56B2B799C25FFF14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23231.1.
PIRiA64131.
RefSeqiNP_439728.1. NC_000907.1.
WP_005693602.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23231; AAC23231; HI_1583.
GeneIDi950446.
KEGGihin:HI1583.
PATRICi20191899. VBIHaeInf48452_1657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23231.1.
PIRiA64131.
RefSeqiNP_439728.1. NC_000907.1.
WP_005693602.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1583.

Proteomic databases

PRIDEiP43832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23231; AAC23231; HI_1583.
GeneIDi950446.
KEGGihin:HI1583.
PATRICi20191899. VBIHaeInf48452_1657.

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiNPNGPLH.
OrthoDBiEOG6JB13C.
PhylomeDBiP43832.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiSYR_HAEIN
AccessioniPrimary (citable) accession number: P43832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.