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P43811

- SPOT_HAEIN

UniProt

P43811 - SPOT_HAEIN

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    3. metal ion binding Source: InterPro
    4. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
    Alternative name(s):
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:spoT
    Ordered Locus Names:HI_1741
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166571Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI1741.

    Structurei

    3D structure databases

    ProteinModelPortaliP43811.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 117100HDAdd
    BLAST
    Domaini601 – 67575ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    KOiK01139.
    OMAiTENDAES.
    OrthoDBiEOG6SV551.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43811-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIARDAHEGQ FRSSGEPYIT HPVAVASIIA QLHLDHEAVM AALLHDVIED    50
    TPYTEEQLKE EFGASVAEIV DGVSKLDKLK FRTRQEAQVE NFRKMILAMT 100
    RDIRVVLIKL ADRTHNMRTL GSLRPDKRRR IAKETLEIYC PLAHRLGIEH 150
    IKNELEDLSF QAMHPHRYEV LKKLVDVARS NRQDLIERIS QEIKVRLENS 200
    GIFARVWGRE KHLYKIYQKM RIKDQEFHSI MDIYAFRVIV KNVDDCYRVL 250
    GQMHNLYKPR PGRVKDYIAV PKANGYQSLQ TSMIGPKGVP VEVHIHTEDM 300
    EQVAEMGITA HWVYKENGKN DSTTAQIRVQ RWLQSLVEIQ QSVGNSFEFI 350
    ENVKSEFFPK EIYVFTPKGR IVELPMGATA VDFAYAVHSD VGNTCVGVTV 400
    EHKPYPLSKA LESGQTVNII TDPNAHPEVA WLNFVVTARA KTRIRHYLKQ 450
    RCEEDAVKLG EVELNVALQP HNLGDFSIQQ IRTVLDALAL SSLDELLREI 500
    GLGNQSASMI AHQFVGVPLE SANTKNLEFE SKILTIAPMQ VGKTQFAQCC 550
    HPILGDPIVG CCTEKNTVVV HHQHCASLKN ACRQSLAKWD NVQSAVNFEA 600
    ELQIEILNEQ NALLSLMTAI SASESSLQNI WTEELENNLL LVILQVCVKD 650
    IKHLANIVHR IKGITGVVNV KRNINEL 677
    Length:677
    Mass (Da):76,726
    Last modified:November 1, 1995 - v1
    Checksum:iFB12CE3C33A18B93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23388.1.
    PIRiF64139.
    RefSeqiNP_439885.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23388; AAC23388; HI_1741.
    GeneIDi950884.
    KEGGihin:HI1741.
    PATRICi20192253. VBIHaeInf48452_1824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23388.1 .
    PIRi F64139.
    RefSeqi NP_439885.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43811.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23388 ; AAC23388 ; HI_1741 .
    GeneIDi 950884.
    KEGGi hin:HI1741.
    PATRICi 20192253. VBIHaeInf48452_1824.

    Phylogenomic databases

    eggNOGi COG0317.
    KOi K01139.
    OMAi TENDAES.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00886 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiSPOT_HAEIN
    AccessioniPrimary (citable) accession number: P43811
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3