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P43802

- NDK_HAEIN

UniProt

P43802 - NDK_HAEIN

Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.By similarity

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATPBy similarity
    Binding sitei59 – 591ATPBy similarity
    Binding sitei87 – 871ATPBy similarity
    Binding sitei93 – 931ATPBy similarity
    Binding sitei104 – 1041ATPBy similarity
    Binding sitei114 – 1141ATPBy similarity
    Active sitei117 – 1171Pros-phosphohistidine intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CTP biosynthetic process Source: UniProtKB-HAMAP
    2. GTP biosynthetic process Source: UniProtKB-HAMAP
    3. UTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinase (EC:2.7.4.6)
    Short name:
    NDK
    Short name:
    NDP kinase
    Alternative name(s):
    Nucleoside-2-P kinase
    Gene namesi
    Name:ndk
    Ordered Locus Names:HI_0876
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 141141Nucleoside diphosphate kinasePRO_0000136990Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0876.

    Structurei

    3D structure databases

    ProteinModelPortaliP43802.
    SMRiP43802. Positions 4-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NDK family.Curated

    Phylogenomic databases

    eggNOGiCOG0105.
    KOiK00940.
    OMAiFTEDEIC.
    OrthoDBiEOG67DPRV.
    PhylomeDBiP43802.

    Family and domain databases

    Gene3Di3.30.70.141. 1 hit.
    HAMAPiMF_00451. NDP_kinase.
    InterProiIPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view]
    PfamiPF00334. NDK. 1 hit.
    [Graphical view]
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00562. NDK. 1 hit.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 1 hit.
    PROSITEiPS00469. NDP_KINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43802-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTERTFSII KPDVVKRNLI GAILTRFEQN GFKIIASKMV RLTREQAEGF    50
    YAEHQGKEFF VPLVEYMMSS PIVVSVLEKE NAVKDYRTLI GTTNPETAAE 100
    GTIRKDFALS QRENSVHGSD SIESANREIA YFFTNSEIFE R 141
    Length:141
    Mass (Da):16,106
    Last modified:November 1, 1995 - v1
    Checksum:i00071DFD5F791C57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22532.1.
    PIRiD64099.
    RefSeqiNP_439037.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22532; AAC22532; HI_0876.
    GeneIDi949884.
    KEGGihin:HI0876.
    PATRICi20190409. VBIHaeInf48452_0918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22532.1 .
    PIRi D64099.
    RefSeqi NP_439037.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43802.
    SMRi P43802. Positions 4-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22532 ; AAC22532 ; HI_0876 .
    GeneIDi 949884.
    KEGGi hin:HI0876.
    PATRICi 20190409. VBIHaeInf48452_0918.

    Phylogenomic databases

    eggNOGi COG0105.
    KOi K00940.
    OMAi FTEDEIC.
    OrthoDBi EOG67DPRV.
    PhylomeDBi P43802.

    Family and domain databases

    Gene3Di 3.30.70.141. 1 hit.
    HAMAPi MF_00451. NDP_kinase.
    InterProi IPR001564. Nucleoside_diP_kinase.
    IPR023005. Nucleoside_diP_kinase_AS.
    [Graphical view ]
    Pfami PF00334. NDK. 1 hit.
    [Graphical view ]
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00562. NDK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 1 hit.
    PROSITEi PS00469. NDP_KINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiNDK_HAEIN
    AccessioniPrimary (citable) accession number: P43802
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3