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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Gene

glpB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor (By similarity).By similarity

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FMNBy similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA), Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB), Anaerobic glycerol-3-phosphate dehydrogenase subunit C (glpC)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-719-MONOMER
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit B (EC:1.1.5.3)
Short name:
Anaerobic G-3-P dehydrogenase subunit B
Short name:
Anaerobic G3Pdhase B
Gene namesi
Name:glpB
Ordered Locus Names:HI_0684
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045631 – 432Anaerobic glycerol-3-phosphate dehydrogenase subunit BAdd BLAST432

Proteomic databases

PRIDEiP43800

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.By similarity

Protein-protein interaction databases

STRINGi71421.HI0684

Structurei

3D structure databases

ProteinModelPortaliP43800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108KJ0 Bacteria
COG3075 LUCA
KOiK00112
OMAiVAINAQC
PhylomeDBiP43800

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00753 Glycerol3P_GlpB, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR009158 G3P_DH_GlpB_su
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PIRSFiPIRSF000141 Anaerobic_G3P_dh, 1 hit
SUPFAMiSSF51905 SSF51905, 4 hits
TIGRFAMsiTIGR03378 glycerol3P_GlpB, 1 hit

Sequencei

Sequence statusi: Complete.

P43800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFDVAIIGG GLAGLTCAIA LQQRGKRCVI INNGQAAIDF ASGSLDLLSR
60 70 80 90 100
MPSTTYGENR AVENLKENIT ALRNELPAHP YSLLGAEKVL AKAQDFERLA
110 120 130 140 150
NELHLDLIGS TEKNHWRVTG LGSLRGAWLS PNSVPTVQGN EPFPHKRIAV
160 170 180 190 200
LGIEGYHDFQ PQLLAANLVL NPQFEHCEVT SGFLNIPQLD ELRKNAREFR
210 220 230 240 250
SVNISQLLEH KLAFKDLVKE IIESAQGAEA VFLPACFGLE NQEFMTALRD
260 270 280 290 300
ATKLALFELP TLPPSLLGMR QRIQLRHKFE SLGGLMINGD SALNATFEGN
310 320 330 340 350
QVRCINTRLL EDEEITADNF VLASGSFFSK GLISEFDKIY EPVFESDIIG
360 370 380 390 400
VEGFNNKDRF TWTAHRFAHP QPYQSAGVAI NAQCQVKKCG QFLTNLYAVG
410 420 430
NVIGGFNALE LGCGSGVAVV TALAVADEIL AK
Length:432
Mass (Da):47,251
Last modified:November 1, 1995 - v1
Checksum:i6D99EEAC75549228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22344.1
RefSeqiNP_438844.1, NC_000907.1
WP_005694609.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22344; AAC22344; HI_0684
GeneIDi950690
KEGGihin:HI0684
PATRICifig|71421.8.peg.715

Similar proteinsi

Entry informationi

Entry nameiGLPB_HAEIN
AccessioniPrimary (citable) accession number: P43800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health