Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit A

Gene

glpA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • FADBy similarity
  • FMNBy similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 4829FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. FMN binding Source: InterPro
  3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC:1.1.5.3)
Short name:
G-3-P dehydrogenase
Gene namesi
Name:glpA
Ordered Locus Names:HI_0685
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cell inner membrane By similarity; Peripheral membrane protein By similarity
Note: Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase.By similarity

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Anaerobic glycerol-3-phosphate dehydrogenase subunit APRO_0000126095Add
BLAST

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.By similarity

Protein-protein interaction databases

STRINGi71421.HI0685.

Structurei

3D structure databases

ProteinModelPortaliP43799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
KOiK00111.
OMAiMIAMNHR.
OrthoDBiEOG651SR7.
PhylomeDBiP43799.

Family and domain databases

InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSPSIYKD VGDLSSLSTD VIIIGGGATG AGIARDCALR GIDCILLERR
60 70 80 90 100
DIATGATGRN HGLLHSGARY AVNDQESAEE CIKENRILRK IARHCVDETE
110 120 130 140 150
GLFITLPEDS LDYQKTFLES CAKSGIDAQA IDPELAKIME PSVNPDLVGA
160 170 180 190 200
VVVPDGSIDP FRLTASNMMD ATENGAKMFT YCEVKNLIRE GGKVIGVNAY
210 220 230 240 250
DHKNRRERQF FAPLVVNAGG IWGQGIAEYA DLKIKMFPAK GALLVMGHRI
260 270 280 290 300
NKLVINRCRK PADADILVPG DTICVIGTTS SRIPYDQIDN MEVTPEEVDI
310 320 330 340 350
LFREGEKLAP SLRHTRVLRA YAGVRPLVAS DDDPSGRNVS RGIVLLDHAE
360 370 380 390 400
RDGLDGFITI TGGKLMTYRL MAEWATDLVC KKLNKTARCV TAEQPLPGST
410 420 430 440 450
ESRQETNQKV ISLPSTIRYS AVYRHGSRAT RLLEKERLDR SMVCECEAVT
460 470 480 490 500
AGEVRYAVDE LDVNNLVDLR RRSRVGMGTC QAELCACRAA GLMNRFEVAT
510 520 530 540 550
PRQSTTQLSA FMEERWRGIE PIAWGEAIRE AEFTSWMYAS VLGLNDVKPL
560
DEQAQQGTDS NEF
Length:563
Mass (Da):61,920
Last modified:November 1, 1995 - v1
Checksum:i7E662A80F4E1EED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22345.1.
PIRiE64086.
RefSeqiNP_438845.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22345; AAC22345; HI_0685.
GeneIDi949605.
KEGGihin:HI0685.
PATRICi20189989. VBIHaeInf48452_0716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22345.1.
PIRiE64086.
RefSeqiNP_438845.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43799.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22345; AAC22345; HI_0685.
GeneIDi949605.
KEGGihin:HI0685.
PATRICi20189989. VBIHaeInf48452_0716.

Phylogenomic databases

eggNOGiCOG0578.
KOiK00111.
OMAiMIAMNHR.
OrthoDBiEOG651SR7.
PhylomeDBiP43799.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Family and domain databases

InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiGLPA_HAEIN
AccessioniPrimary (citable) accession number: P43799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.