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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110NAD; via amide nitrogenUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Binding sitei143NAD; via amide nitrogenUniRule annotation1
Active sitei195Proton acceptorUniRule annotation1
Binding sitei259NADUniRule annotation1
Binding sitei285NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-624-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:HI_0605
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001379691 – 335Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST335

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0605

Structurei

3D structure databases

ProteinModelPortaliP43798
SMRiP43798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 260Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF Bacteria
COG0240 LUCA
KOiK00057
OMAiWLCKGFE
PhylomeDBiP43798

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

P43798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSQTPITV LGAGSYGTAL AITFSRNGSP THLWGHNPAH IAQMQTERQN
60 70 80 90 100
YRFLPDVIFP EDLHLESNLA QAMEYSQDIL IVVPSHAFGE ILIKIKPHLK
110 120 130 140 150
AHHRLIWATK GLERNTGRLL QTVVEEQLGT QYPLAVLSGP TFAKELAQGL
160 170 180 190 200
PSAITLAANN EQFAREFQSR IHCSKGFRVY INSDMTGVQL GGAIKNVIAI
210 220 230 240 250
GAGISDGMGF GANARTALIT RGIAEITRLG ISLGANTNTF MGMSGLGDLV
260 270 280 290 300
LTCTDNQSRN RRFGLMLGKG LDAQMAMENI GQVVEGFYNT KEAYLLAQRQ
310 320 330
GVEMPITEQI YQMLFCGKSA QDVAISLLGR ACKGE
Length:335
Mass (Da):36,394
Last modified:November 1, 1995 - v1
Checksum:i4913F8F2203B7CFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22264.1
PIRiF64080
RefSeqiNP_438763.1, NC_000907.1
WP_005694541.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22264; AAC22264; HI_0605
GeneIDi949436
KEGGihin:HI0605
PATRICifig|71421.8.peg.629

Entry informationi

Entry nameiGPDA_HAEIN
AccessioniPrimary (citable) accession number: P43798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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