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P43794

- GLNA_HAEIN

UniProt

P43794 - GLNA_HAEIN

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Protein

Glutamine synthetase

Gene

glnA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:HI_0865
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Glutamine synthetasePRO_0000153238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi71421.HI0865.

Structurei

3D structure databases

ProteinModelPortaliP43794.
SMRiP43794. Positions 9-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiDMLLMPI.
OrthoDBiEOG6B360N.
PhylomeDBiP43794.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43794 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNANAIANV FKLIEENNVK FVLLRFTDIK GKEHGVSIPV SLVDEDMFED
60 70 80 90 100
GKMFDGSSVE GWKTINKADM LLMPMAETAI VDPFAQIPTL SIRCSVYEPT
110 120 130 140 150
TMQSYDRDPR SIAIRAENYM RSTGIADQAF FGPEPEFFLF DDVRFNVSMN
160 170 180 190 200
KASFSIDDIE AAWNTNKKYE EGNNAYRPLK KGGYCAVAPI DSAHDIRSEM
210 220 230 240 250
CLILEEMGLV IEAHHHEVAT AGQNEIATKF NTLTLKADET QIYKHVVQNV
260 270 280 290 300
ALEHGKTACF MPKPITGDNG SGMHCNMSLS KDGKNIFQGD KYAGLSETAL
310 320 330 340 350
YYIGGIIKHA KALNAFTNPS TNSYKRLVPG YEAPVLLAYS ASNRSASIRI
360 370 380 390 400
PAVTNPKAIR VEARFPDPLA NPYLAFAALL MAGLDGVVNK IHPGDAMDKN
410 420 430 440 450
LYDLPPEELK DIPAVASSLE EALNSLEKDY EFLTQGGVFA KDFIDAFISI
460 470
KRKEVERLNM APHPVEFEMY YA
Length:472
Mass (Da):52,344
Last modified:November 1, 1995 - v1
Checksum:i160DDD0F91B28046
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22524.1.
PIRiI64098.
RefSeqiNP_439025.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22524; AAC22524; HI_0865.
GeneIDi949878.
KEGGihin:HI0865.
PATRICi20190385. VBIHaeInf48452_0906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22524.1 .
PIRi I64098.
RefSeqi NP_439025.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43794.
SMRi P43794. Positions 9-472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22524 ; AAC22524 ; HI_0865 .
GeneIDi 949878.
KEGGi hin:HI0865.
PATRICi 20190385. VBIHaeInf48452_0906.

Phylogenomic databases

eggNOGi COG0174.
KOi K01915.
OMAi DMLLMPI.
OrthoDBi EOG6B360N.
PhylomeDBi P43794.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiGLNA_HAEIN
AccessioniPrimary (citable) accession number: P43794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3