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P43794 (GLNA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:HI_0865
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Glutamine synthetase
PRO_0000153238

Amino acid modifications

Modified residue4021O-AMP-tyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P43794 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 160DDD0F91B28046

FASTA47252,344
        10         20         30         40         50         60 
MPNANAIANV FKLIEENNVK FVLLRFTDIK GKEHGVSIPV SLVDEDMFED GKMFDGSSVE 

        70         80         90        100        110        120 
GWKTINKADM LLMPMAETAI VDPFAQIPTL SIRCSVYEPT TMQSYDRDPR SIAIRAENYM 

       130        140        150        160        170        180 
RSTGIADQAF FGPEPEFFLF DDVRFNVSMN KASFSIDDIE AAWNTNKKYE EGNNAYRPLK 

       190        200        210        220        230        240 
KGGYCAVAPI DSAHDIRSEM CLILEEMGLV IEAHHHEVAT AGQNEIATKF NTLTLKADET 

       250        260        270        280        290        300 
QIYKHVVQNV ALEHGKTACF MPKPITGDNG SGMHCNMSLS KDGKNIFQGD KYAGLSETAL 

       310        320        330        340        350        360 
YYIGGIIKHA KALNAFTNPS TNSYKRLVPG YEAPVLLAYS ASNRSASIRI PAVTNPKAIR 

       370        380        390        400        410        420 
VEARFPDPLA NPYLAFAALL MAGLDGVVNK IHPGDAMDKN LYDLPPEELK DIPAVASSLE 

       430        440        450        460        470 
EALNSLEKDY EFLTQGGVFA KDFIDAFISI KRKEVERLNM APHPVEFEMY YA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22524.1.
PIRI64098.
RefSeqNP_439025.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43794.
SMRP43794. Positions 9-472.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22524; AAC22524; HI_0865.
GeneID949878.
KEGGhin:HI0865.
PATRIC20190385. VBIHaeInf48452_0906.

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMADMLLMPI.
OrthoDBEOG6B360N.
PhylomeDBP43794.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_HAEIN
AccessionPrimary (citable) accession number: P43794
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names