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P43794

- GLNA_HAEIN

UniProt

P43794 - GLNA_HAEIN

Protein

Glutamine synthetase

Gene

glnA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:HI_0865
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Glutamine synthetasePRO_0000153238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei402 – 4021O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0865.

    Structurei

    3D structure databases

    ProteinModelPortaliP43794.
    SMRiP43794. Positions 9-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiDMLLMPI.
    OrthoDBiEOG6B360N.
    PhylomeDBiP43794.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43794-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNANAIANV FKLIEENNVK FVLLRFTDIK GKEHGVSIPV SLVDEDMFED    50
    GKMFDGSSVE GWKTINKADM LLMPMAETAI VDPFAQIPTL SIRCSVYEPT 100
    TMQSYDRDPR SIAIRAENYM RSTGIADQAF FGPEPEFFLF DDVRFNVSMN 150
    KASFSIDDIE AAWNTNKKYE EGNNAYRPLK KGGYCAVAPI DSAHDIRSEM 200
    CLILEEMGLV IEAHHHEVAT AGQNEIATKF NTLTLKADET QIYKHVVQNV 250
    ALEHGKTACF MPKPITGDNG SGMHCNMSLS KDGKNIFQGD KYAGLSETAL 300
    YYIGGIIKHA KALNAFTNPS TNSYKRLVPG YEAPVLLAYS ASNRSASIRI 350
    PAVTNPKAIR VEARFPDPLA NPYLAFAALL MAGLDGVVNK IHPGDAMDKN 400
    LYDLPPEELK DIPAVASSLE EALNSLEKDY EFLTQGGVFA KDFIDAFISI 450
    KRKEVERLNM APHPVEFEMY YA 472
    Length:472
    Mass (Da):52,344
    Last modified:November 1, 1995 - v1
    Checksum:i160DDD0F91B28046
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22524.1.
    PIRiI64098.
    RefSeqiNP_439025.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22524; AAC22524; HI_0865.
    GeneIDi949878.
    KEGGihin:HI0865.
    PATRICi20190385. VBIHaeInf48452_0906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22524.1 .
    PIRi I64098.
    RefSeqi NP_439025.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43794.
    SMRi P43794. Positions 9-472.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22524 ; AAC22524 ; HI_0865 .
    GeneIDi 949878.
    KEGGi hin:HI0865.
    PATRICi 20190385. VBIHaeInf48452_0906.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi DMLLMPI.
    OrthoDBi EOG6B360N.
    PhylomeDBi P43794.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiGLNA_HAEIN
    AccessioniPrimary (citable) accession number: P43794
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3