Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateBy similarity1
Binding sitei113SubstrateBy similarity1
Binding sitei116SubstrateBy similarity1
Active sitei128Proton donorPROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenBy similarity1
Sitei168Important for catalysisBy similarity1
Binding sitei211NADPBy similarity1
Binding sitei242NADPBy similarity1
Binding sitei380SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:HI_0189
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827701 – 449NADP-specific glutamate dehydrogenaseAdd BLAST449

Proteomic databases

PRIDEiP43793.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0189.

Structurei

3D structure databases

ProteinModelPortaliP43793.
SMRiP43793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
KOiK00262.
OMAiVPWVDDA.
PhylomeDBiP43793.

Family and domain databases

CDDicd05313. NAD_bind_2_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVASLDAF LTKVAQRDGY QPEFLQAVRE VFTSIWPFLE ANPKYRSEAL
60 70 80 90 100
LERLVEPERA FQFRVAWTDD KGQVQVNRAF RVQFNSAIGP FKGGMRFHPS
110 120 130 140 150
VNLSILKFLG FEQIFKNALT TLPMGGAKGG SDFDPKGKSD AEVMRFCQAL
160 170 180 190 200
MAELYRHVGA DTDVPAGDIG VGGREVGYLA GYMKKLSNQS ACVFTGRGLS
210 220 230 240 250
FGGSLIRPEA TGYGLIYFAQ AMLAEKGDSF AGKVVSVSGS GNVAQYAIEK
260 270 280 290 300
ALSLGAKVVT CSDSSGYVYD PNGFTTEKLA ALFDIKNTKR GRVKDYAEQF
310 320 330 340 350
GLQYFEGKRP WEVQVDIALP CATQNELELS DAQRLIKNGV KLVAEGANMP
360 370 380 390 400
TTIEATEALL AADVLFGPGK AANAGGVATS GLEMAQSSQR LYWTAEEVDA
410 420 430 440
QLHRIMLDIH ANCKKYGTIE GQENINYVVG ANVAGFVKVA DAMLAQGVY
Length:449
Mass (Da):48,660
Last modified:November 1, 1995 - v1
Checksum:i4698E0CD6C665A34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21858.1.
PIRiA64053.
RefSeqiNP_438358.1. NC_000907.1.
WP_005664327.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21858; AAC21858; HI_0189.
GeneIDi951095.
KEGGihin:HI0189.
PATRICi20188875. VBIHaeInf48452_0194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21858.1.
PIRiA64053.
RefSeqiNP_438358.1. NC_000907.1.
WP_005664327.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43793.
SMRiP43793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0189.

Proteomic databases

PRIDEiP43793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC21858; AAC21858; HI_0189.
GeneIDi951095.
KEGGihin:HI0189.
PATRICi20188875. VBIHaeInf48452_0194.

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
KOiK00262.
OMAiVPWVDDA.
PhylomeDBiP43793.

Family and domain databases

CDDicd05313. NAD_bind_2_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHE4_HAEIN
AccessioniPrimary (citable) accession number: P43793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.