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P43793

- DHE4_HAEIN

UniProt

P43793 - DHE4_HAEIN

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Protein

NADP-specific glutamate dehydrogenase

Gene
gdhA, HI_0189
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Active sitei128 – 1281Proton donor By similarity
Binding sitei167 – 1671Substrate; via carbonyl oxygen By similarity
Sitei168 – 1681Important for catalysis By similarity
Binding sitei211 – 2111NADP By similarity
Binding sitei242 – 2421NADP By similarity
Binding sitei380 – 3801Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:HI_0189
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449NADP-specific glutamate dehydrogenasePRO_0000182770Add
BLAST

Proteomic databases

PRIDEiP43793.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi71421.HI0189.

Structurei

3D structure databases

ProteinModelPortaliP43793.
SMRiP43793. Positions 6-449.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
KOiK00262.
OMAiIMLDIHA.
OrthoDBiEOG65XN4D.
PhylomeDBiP43793.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43793-1 [UniParc]FASTAAdd to Basket

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MSKVASLDAF LTKVAQRDGY QPEFLQAVRE VFTSIWPFLE ANPKYRSEAL    50
LERLVEPERA FQFRVAWTDD KGQVQVNRAF RVQFNSAIGP FKGGMRFHPS 100
VNLSILKFLG FEQIFKNALT TLPMGGAKGG SDFDPKGKSD AEVMRFCQAL 150
MAELYRHVGA DTDVPAGDIG VGGREVGYLA GYMKKLSNQS ACVFTGRGLS 200
FGGSLIRPEA TGYGLIYFAQ AMLAEKGDSF AGKVVSVSGS GNVAQYAIEK 250
ALSLGAKVVT CSDSSGYVYD PNGFTTEKLA ALFDIKNTKR GRVKDYAEQF 300
GLQYFEGKRP WEVQVDIALP CATQNELELS DAQRLIKNGV KLVAEGANMP 350
TTIEATEALL AADVLFGPGK AANAGGVATS GLEMAQSSQR LYWTAEEVDA 400
QLHRIMLDIH ANCKKYGTIE GQENINYVVG ANVAGFVKVA DAMLAQGVY 449
Length:449
Mass (Da):48,660
Last modified:November 1, 1995 - v1
Checksum:i4698E0CD6C665A34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21858.1.
PIRiA64053.
RefSeqiNP_438358.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21858; AAC21858; HI_0189.
GeneIDi951095.
KEGGihin:HI0189.
PATRICi20188875. VBIHaeInf48452_0194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21858.1 .
PIRi A64053.
RefSeqi NP_438358.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43793.
SMRi P43793. Positions 6-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0189.

Proteomic databases

PRIDEi P43793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21858 ; AAC21858 ; HI_0189 .
GeneIDi 951095.
KEGGi hin:HI0189.
PATRICi 20188875. VBIHaeInf48452_0194.

Phylogenomic databases

eggNOGi COG0334.
KOi K00262.
OMAi IMLDIHA.
OrthoDBi EOG65XN4D.
PhylomeDBi P43793.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDHE4_HAEIN
AccessioniPrimary (citable) accession number: P43793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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