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P43783 (GSHR_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione reductase

Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:gor
Ordered Locus Names:HI_0161
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Glutathione reductase
PRO_0000067976

Regions

Nucleotide binding34 – 429FAD By similarity

Sites

Active site4451Proton acceptor By similarity

Amino acid modifications

Disulfide bond42 ↔ 47Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P43783 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 846988C215FE949A

FASTA45649,329
        10         20         30         40         50         60 
MTKHYDYIAI GGGSGGIASL NRAASYGKKC AIIEAKHLGG TCVNVGCVPK KVMFYGAHIA 

        70         80         90        100        110        120 
EAINNYAPDY GFDVEVKKFD FSKLIESRQA YISRIHTSYN NVLAKNNIDV INGFGKFVDA 

       130        140        150        160        170        180 
HTIEVTLADG TKEQVTADHI LIATGGRPYR PNIKGQEYGI DSDGFFALTE LPKRAAVIGA 

       190        200        210        220        230        240 
GYIAVELSGV LNSLGVETHL LVRRHAPMRN QDPLIVETLV EVLAQDGIQL HTNSTPSEIV 

       250        260        270        280        290        300 
KNADGSLTVR CDGQSDVTVD CVIWAAGRVP TTDKIGLENA GVETNEHGYV KVDKYQNTNV 

       310        320        330        340        350        360 
KGIYAVGDII ENGIELTPVA VAAGRRLSER LFNNKPTEYL DYSLVPTVVF SHPPIGTVGL 

       370        380        390        400        410        420 
TEPQAIEQYG AENVKVYKSS FTAMYTAVTQ HRQPCKMKLV CVGKDEKVVG LHGIGFGVDE 

       430        440        450 
MIQGFAVAIK MGATKADFDN TVAIHPTGSE EFVTMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20229 Genomic DNA. Translation: AAA62137.1.
L42023 Genomic DNA. Translation: AAC21833.1.
PIRA64052.
RefSeqNP_438331.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43783.
SMRP43783. Positions 2-456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21833; AAC21833; HI_0161.
GeneID951071.
KEGGhin:HI0161.
PATRIC20188821. VBIHaeInf48452_0167.

Phylogenomic databases

eggNOGCOG1249.
KOK00383.
OMAHRQPCKM.
OrthoDBEOG6QCD6D.
PhylomeDBP43783.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_HAEIN
AccessionPrimary (citable) accession number: P43783
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names