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P43776 (DHPS_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropteroate synthase

Short name=DHPS
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene names
Name:folP-A
Ordered Locus Names:HI_1336
AND
Name:folP-B
Ordered Locus Names:HI_1464
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Dihydropteroate synthase
PRO_0000168210

Regions

Domain15 – 267253Pterin-binding
Region62 – 632Substrate binding By similarity

Sites

Metal binding221Magnesium By similarity
Binding site301Substrate By similarity
Binding site961Substrate By similarity
Binding site1151Substrate By similarity
Binding site1851Substrate By similarity
Binding site2211Substrate By similarity
Binding site2551Substrate By similarity
Binding site2571Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P43776 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8164FD3FBB7B9A30

FASTA27530,330
        10         20         30         40         50         60 
MKLYANNKCL DLSVPQIMGI LNFTPDSFSD SGQFFSLDKA LFQVEKMLEE GATIIDIGGE 

        70         80         90        100        110        120 
STRPNADEVS EQEELHRVVP VVEAVRNRFD CWISVDSSKA VVMREAANVG MDLINDIRAL 

       130        140        150        160        170        180 
QEPNALETAV KLALPVCIMH MQGQPRTMQA NPYYENVVQD VLAFLQKRTN ECLSAGIKKE 

       190        200        210        220        230        240 
NLIWDMGFGF GKSVQHNYQL LQNLNEFCQI GYPVLAGLSR KSMIGAVLDK PVDQRIIGSA 

       250        260        270 
AGALIAVQKG AKILRVHDVA ATSDMLKVWQ ATANA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22983.1.
L42023 Genomic DNA. Translation: AAC23111.1.
PIRE64117.
RefSeqNP_439487.1. NC_000907.1.
NP_439615.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43776.
SMRP43776. Positions 1-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22983; AAC22983; HI_1336.
AAC23111; AAC23111; HI_1464.
GeneID950351.
950701.
KEGGhin:HI1336.
hin:HI1464.
PATRIC20191355. VBIHaeInf48452_1388.

Phylogenomic databases

eggNOGCOG0294.
KOK00796.
OMASVYEHGV.
OrthoDBEOG67T5P5.
ProtClustDBCLSK870099.

Enzyme and pathway databases

UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS_HAEIN
AccessionPrimary (citable) accession number: P43776
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 13, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names