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P43776

- DHPS_HAEIN

UniProt

P43776 - DHPS_HAEIN

Protein

Dihydropteroate synthase

Gene

folP-A

more
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.By similarity

    Catalytic activityi

    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221MagnesiumBy similarity
    Binding sitei30 – 301SubstrateBy similarity
    Binding sitei96 – 961SubstrateBy similarity
    Binding sitei115 – 1151SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Binding sitei221 – 2211SubstrateBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Binding sitei257 – 2571SubstrateBy similarity

    GO - Molecular functioni

    1. dihydropteroate synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. response to antibiotic Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Antibiotic resistance, Folate biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydropteroate synthase (EC:2.5.1.15)
    Short name:
    DHPS
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
    Gene namesi
    Name:folP-A
    Ordered Locus Names:HI_1336
    AND
    Name:folP-B
    Ordered Locus Names:HI_1464
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Dihydropteroate synthasePRO_0000168210Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1464.

    Structurei

    3D structure databases

    ProteinModelPortaliP43776.
    SMRiP43776. Positions 1-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 267253Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 632Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DHPS family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    KOiK00796.
    OMAiDCWISVD.
    OrthoDBiEOG67T5P5.
    PhylomeDBiP43776.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43776-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYANNKCL DLSVPQIMGI LNFTPDSFSD SGQFFSLDKA LFQVEKMLEE    50
    GATIIDIGGE STRPNADEVS EQEELHRVVP VVEAVRNRFD CWISVDSSKA 100
    VVMREAANVG MDLINDIRAL QEPNALETAV KLALPVCIMH MQGQPRTMQA 150
    NPYYENVVQD VLAFLQKRTN ECLSAGIKKE NLIWDMGFGF GKSVQHNYQL 200
    LQNLNEFCQI GYPVLAGLSR KSMIGAVLDK PVDQRIIGSA AGALIAVQKG 250
    AKILRVHDVA ATSDMLKVWQ ATANA 275
    Length:275
    Mass (Da):30,330
    Last modified:November 1, 1995 - v1
    Checksum:i8164FD3FBB7B9A30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22983.1.
    L42023 Genomic DNA. Translation: AAC23111.1.
    PIRiE64117.
    RefSeqiNP_439487.1. NC_000907.1.
    NP_439615.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22983; AAC22983; HI_1336.
    AAC23111; AAC23111; HI_1464.
    GeneIDi950351.
    950701.
    KEGGihin:HI1336.
    hin:HI1464.
    PATRICi20191355. VBIHaeInf48452_1388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22983.1 .
    L42023 Genomic DNA. Translation: AAC23111.1 .
    PIRi E64117.
    RefSeqi NP_439487.1. NC_000907.1.
    NP_439615.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43776.
    SMRi P43776. Positions 1-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22983 ; AAC22983 ; HI_1336 .
    AAC23111 ; AAC23111 ; HI_1464 .
    GeneIDi 950351.
    950701.
    KEGGi hin:HI1336.
    hin:HI1464.
    PATRICi 20191355. VBIHaeInf48452_1388.

    Phylogenomic databases

    eggNOGi COG0294.
    KOi K00796.
    OMAi DCWISVD.
    OrthoDBi EOG67T5P5.
    PhylomeDBi P43776.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00156 .

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiDHPS_HAEIN
    AccessioniPrimary (citable) accession number: P43776
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3