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Protein

Dihydropteroate synthase

Gene

folP-A

more
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity).By similarity

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221MagnesiumBy similarity
Binding sitei30 – 301SubstrateBy similarity
Binding sitei96 – 961SubstrateBy similarity
Binding sitei115 – 1151SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei255 – 2551SubstrateBy similarity
Binding sitei257 – 2571SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP-A
Ordered Locus Names:HI_1336
AND
Name:folP-B
Ordered Locus Names:HI_1464
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Dihydropteroate synthasePRO_0000168210Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1464.

Structurei

3D structure databases

ProteinModelPortaliP43776.
SMRiP43776. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 267253Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 632Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
KOiK00796.
OMAiSIDTYHA.
OrthoDBiEOG67T5P5.
PhylomeDBiP43776.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYANNKCL DLSVPQIMGI LNFTPDSFSD SGQFFSLDKA LFQVEKMLEE
60 70 80 90 100
GATIIDIGGE STRPNADEVS EQEELHRVVP VVEAVRNRFD CWISVDSSKA
110 120 130 140 150
VVMREAANVG MDLINDIRAL QEPNALETAV KLALPVCIMH MQGQPRTMQA
160 170 180 190 200
NPYYENVVQD VLAFLQKRTN ECLSAGIKKE NLIWDMGFGF GKSVQHNYQL
210 220 230 240 250
LQNLNEFCQI GYPVLAGLSR KSMIGAVLDK PVDQRIIGSA AGALIAVQKG
260 270
AKILRVHDVA ATSDMLKVWQ ATANA
Length:275
Mass (Da):30,330
Last modified:November 1, 1995 - v1
Checksum:i8164FD3FBB7B9A30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22983.1.
L42023 Genomic DNA. Translation: AAC23111.1.
PIRiE64117.
RefSeqiNP_439487.1. NC_000907.1.
NP_439615.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22983; AAC22983; HI_1336.
AAC23111; AAC23111; HI_1464.
GeneIDi950351.
950701.
KEGGihin:HI1336.
hin:HI1464.
PATRICi20191355. VBIHaeInf48452_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22983.1.
L42023 Genomic DNA. Translation: AAC23111.1.
PIRiE64117.
RefSeqiNP_439487.1. NC_000907.1.
NP_439615.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43776.
SMRiP43776. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22983; AAC22983; HI_1336.
AAC23111; AAC23111; HI_1464.
GeneIDi950351.
950701.
KEGGihin:HI1336.
hin:HI1464.
PATRICi20191355. VBIHaeInf48452_1388.

Phylogenomic databases

eggNOGiCOG0294.
KOiK00796.
OMAiSIDTYHA.
OrthoDBiEOG67T5P5.
PhylomeDBiP43776.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiDHPS_HAEIN
AccessioniPrimary (citable) accession number: P43776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.