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P43774

- 6PGD_HAEIN

UniProt

P43774 - 6PGD_HAEIN

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, HI_0553
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADP By similarity
Binding sitei104 – 1041Substrate By similarity
Active sitei185 – 1851Proton acceptor By similarity
Active sitei192 – 1921Proton donor By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity
Binding sitei289 – 2891Substrate By similarity
Binding sitei447 – 4471Substrate; shared with dimeric partner By similarity
Binding sitei453 – 4531Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADP By similarity
Nucleotide bindingi34 – 363NADP By similarity
Nucleotide bindingi76 – 783NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP43774.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:HI_0553
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090041Add
BLAST

Proteomic databases

PRIDEiP43774.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi71421.HI0553.

Structurei

3D structure databases

ProteinModelPortaliP43774.
SMRiP43774. Positions 4-475.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1323Substrate binding By similarity
Regioni188 – 1892Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.
PhylomeDBiP43774.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43774-1 [UniParc]FASTAAdd to Basket

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MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLQGAAKG    50
TNIIGAYSLE DLAAKLEKPR KVMLMVRAGD VVDQFIEALL PHLEEGDIII 100
DGGNSNYPDT NRRVKALAEK GIRFIGSGVS GGEEGARHGP SIMPGGNQEA 150
WQYVKPIFQA ISAKTEQGEP CCDWVGGEGA GHFVKMVHNG IEYGDMQLIC 200
EAYQFLKEGL GLSYEEMQAI FAEWKNTELD SYLIDITTDI LGYKDASGEP 250
LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSSFKDQRVA 300
ANQLFGKTIT PVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEQFG 350
WDINYGATAL LWREGCIIRS RFLGNIRDAY EANPNLVFLG SDSYFKGILE 400
NALSDWRKVV AKSIEVGIPM PCMASAITFL DGYTSARLPA NLLQAQRDYF 450
GAHTYERTDK PRGEFFHTNW TGRGGNTAST TYDV 484
Length:484
Mass (Da):53,140
Last modified:November 1, 1995 - v1
Checksum:i8381EEB3C704C5DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22210.1.
PIRiC64077.
RefSeqiNP_438711.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22210; AAC22210; HI_0553.
GeneIDi949604.
KEGGihin:HI0553.
PATRICi20189661. VBIHaeInf48452_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22210.1 .
PIRi C64077.
RefSeqi NP_438711.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43774.
SMRi P43774. Positions 4-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0553.

Proteomic databases

PRIDEi P43774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22210 ; AAC22210 ; HI_0553 .
GeneIDi 949604.
KEGGi hin:HI0553.
PATRICi 20189661. VBIHaeInf48452_0573.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.
PhylomeDBi P43774.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
SABIO-RK P43774.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry namei6PGD_HAEIN
AccessioniPrimary (citable) accession number: P43774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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