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P43774

- 6PGD_HAEIN

UniProt

P43774 - 6PGD_HAEIN

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041NADPBy similarity
    Binding sitei104 – 1041SubstrateBy similarity
    Active sitei185 – 1851Proton acceptorBy similarity
    Active sitei192 – 1921Proton donorBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Binding sitei447 – 4471Substrate; shared with dimeric partnerBy similarity
    Binding sitei453 – 4531Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity
    Nucleotide bindingi34 – 363NADPBy similarity
    Nucleotide bindingi76 – 783NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKP43774.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:HI_0553
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090041Add
    BLAST

    Proteomic databases

    PRIDEiP43774.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0553.

    Structurei

    3D structure databases

    ProteinModelPortaliP43774.
    SMRiP43774. Positions 4-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Substrate bindingBy similarity
    Regioni188 – 1892Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.
    PhylomeDBiP43774.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43774-1 [UniParc]FASTAAdd to Basket

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    MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLQGAAKG    50
    TNIIGAYSLE DLAAKLEKPR KVMLMVRAGD VVDQFIEALL PHLEEGDIII 100
    DGGNSNYPDT NRRVKALAEK GIRFIGSGVS GGEEGARHGP SIMPGGNQEA 150
    WQYVKPIFQA ISAKTEQGEP CCDWVGGEGA GHFVKMVHNG IEYGDMQLIC 200
    EAYQFLKEGL GLSYEEMQAI FAEWKNTELD SYLIDITTDI LGYKDASGEP 250
    LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSSFKDQRVA 300
    ANQLFGKTIT PVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEQFG 350
    WDINYGATAL LWREGCIIRS RFLGNIRDAY EANPNLVFLG SDSYFKGILE 400
    NALSDWRKVV AKSIEVGIPM PCMASAITFL DGYTSARLPA NLLQAQRDYF 450
    GAHTYERTDK PRGEFFHTNW TGRGGNTAST TYDV 484
    Length:484
    Mass (Da):53,140
    Last modified:November 1, 1995 - v1
    Checksum:i8381EEB3C704C5DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22210.1.
    PIRiC64077.
    RefSeqiNP_438711.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22210; AAC22210; HI_0553.
    GeneIDi949604.
    KEGGihin:HI0553.
    PATRICi20189661. VBIHaeInf48452_0573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22210.1 .
    PIRi C64077.
    RefSeqi NP_438711.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43774.
    SMRi P43774. Positions 4-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0553.

    Proteomic databases

    PRIDEi P43774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22210 ; AAC22210 ; HI_0553 .
    GeneIDi 949604.
    KEGGi hin:HI0553.
    PATRICi 20189661. VBIHaeInf48452_0573.

    Phylogenomic databases

    eggNOGi COG0362.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.
    PhylomeDBi P43774.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    SABIO-RK P43774.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry namei6PGD_HAEIN
    AccessioniPrimary (citable) accession number: P43774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3