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P43774 (6PGD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating

EC=1.1.1.44
Gene names
Name:gnd
Ordered Locus Names:HI_0553
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4844846-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090041

Regions

Nucleotide binding11 – 166NADP By similarity
Nucleotide binding34 – 363NADP By similarity
Nucleotide binding76 – 783NADP By similarity
Region130 – 1323Substrate binding By similarity
Region188 – 1892Substrate binding By similarity

Sites

Active site1851Proton acceptor By similarity
Active site1921Proton donor By similarity
Binding site1041NADP By similarity
Binding site1041Substrate By similarity
Binding site1931Substrate By similarity
Binding site2621Substrate; via amide nitrogen By similarity
Binding site2891Substrate By similarity
Binding site4471Substrate; shared with dimeric partner By similarity
Binding site4531Substrate; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
P43774 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8381EEB3C704C5DA

FASTA48453,140
        10         20         30         40         50         60 
MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLQGAAKG TNIIGAYSLE 

        70         80         90        100        110        120 
DLAAKLEKPR KVMLMVRAGD VVDQFIEALL PHLEEGDIII DGGNSNYPDT NRRVKALAEK 

       130        140        150        160        170        180 
GIRFIGSGVS GGEEGARHGP SIMPGGNQEA WQYVKPIFQA ISAKTEQGEP CCDWVGGEGA 

       190        200        210        220        230        240 
GHFVKMVHNG IEYGDMQLIC EAYQFLKEGL GLSYEEMQAI FAEWKNTELD SYLIDITTDI 

       250        260        270        280        290        300 
LGYKDASGEP LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSSFKDQRVA 

       310        320        330        340        350        360 
ANQLFGKTIT PVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEQFG WDINYGATAL 

       370        380        390        400        410        420 
LWREGCIIRS RFLGNIRDAY EANPNLVFLG SDSYFKGILE NALSDWRKVV AKSIEVGIPM 

       430        440        450        460        470        480 
PCMASAITFL DGYTSARLPA NLLQAQRDYF GAHTYERTDK PRGEFFHTNW TGRGGNTAST 


TYDV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22210.1.
PIRC64077.
RefSeqNP_438711.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43774.
SMRP43774. Positions 4-475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0553.

Proteomic databases

PRIDEP43774.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22210; AAC22210; HI_0553.
GeneID949604.
KEGGhin:HI0553.
PATRIC20189661. VBIHaeInf48452_0573.

Phylogenomic databases

eggNOGCOG0362.
KOK00033.
OMADKDGVFH.
OrthoDBEOG6MSS4W.
PhylomeDBP43774.

Enzyme and pathway databases

SABIO-RKP43774.
UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_HAEIN
AccessionPrimary (citable) accession number: P43774
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names