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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADPBy similarity
Binding sitei104 – 1041SubstrateBy similarity
Active sitei185 – 1851Proton acceptorBy similarity
Active sitei192 – 1921Proton donorBy similarity
Binding sitei193 – 1931SubstrateBy similarity
Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Binding sitei447 – 4471Substrate; shared with dimeric partnerBy similarity
Binding sitei453 – 4531Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADPBy similarity
Nucleotide bindingi34 – 363NADPBy similarity
Nucleotide bindingi76 – 783NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP43774.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:HI_0553
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090041Add
BLAST

Proteomic databases

PRIDEiP43774.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0553.

Structurei

3D structure databases

ProteinModelPortaliP43774.
SMRiP43774. Positions 4-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1323Substrate bindingBy similarity
Regioni188 – 1892Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiSDEYNWD.
OrthoDBiEOG6MSS4W.
PhylomeDBiP43774.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKGDIGVI GLAVMGQNLI LNMNDHGFKV VAYNRTTSKV DEFLQGAAKG
60 70 80 90 100
TNIIGAYSLE DLAAKLEKPR KVMLMVRAGD VVDQFIEALL PHLEEGDIII
110 120 130 140 150
DGGNSNYPDT NRRVKALAEK GIRFIGSGVS GGEEGARHGP SIMPGGNQEA
160 170 180 190 200
WQYVKPIFQA ISAKTEQGEP CCDWVGGEGA GHFVKMVHNG IEYGDMQLIC
210 220 230 240 250
EAYQFLKEGL GLSYEEMQAI FAEWKNTELD SYLIDITTDI LGYKDASGEP
260 270 280 290 300
LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITESVFARC VSSFKDQRVA
310 320 330 340 350
ANQLFGKTIT PVEGDKKVWI EAVRKALLAS KIISYAQGFM LIREASEQFG
360 370 380 390 400
WDINYGATAL LWREGCIIRS RFLGNIRDAY EANPNLVFLG SDSYFKGILE
410 420 430 440 450
NALSDWRKVV AKSIEVGIPM PCMASAITFL DGYTSARLPA NLLQAQRDYF
460 470 480
GAHTYERTDK PRGEFFHTNW TGRGGNTAST TYDV
Length:484
Mass (Da):53,140
Last modified:November 1, 1995 - v1
Checksum:i8381EEB3C704C5DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22210.1.
PIRiC64077.
RefSeqiNP_438711.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22210; AAC22210; HI_0553.
GeneIDi949604.
KEGGihin:HI0553.
PATRICi20189661. VBIHaeInf48452_0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22210.1.
PIRiC64077.
RefSeqiNP_438711.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43774.
SMRiP43774. Positions 4-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0553.

Proteomic databases

PRIDEiP43774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22210; AAC22210; HI_0553.
GeneIDi949604.
KEGGihin:HI0553.
PATRICi20189661. VBIHaeInf48452_0573.

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiSDEYNWD.
OrthoDBiEOG6MSS4W.
PhylomeDBiP43774.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.
SABIO-RKP43774.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry namei6PGD_HAEIN
AccessioniPrimary (citable) accession number: P43774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.