ATP-dependent hsl protease ATP-binding subunit hslU - Haemophilus influenzae

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Reviewed, UniProtKB/Swiss-Prot P43773 (HSLU_HAEIN)

Last modified June 16, 2009. Version 75. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
ATP-dependent hsl protease ATP-binding subunit hslU

Gene names

Name:	hslU
Ordered Locus Names:	HI0497

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Chaperone subunit of a proteasome-like degradation complex. HAMAP MF_00249
Subunit structure	A double ring-shaped homohexamer of hslV is capped on each side by a ring-shaped hslU homohexamer. HAMAP MF_00249
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the clpX chaperone family. HslU subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	HslUV protease complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro peptidase activity, acting on L-amino acid peptides Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

444

ATP-dependent hsl protease ATP-binding subunit hslU HAMAP MF_00249

PRO_0000160508

Regions

Nucleotide binding

8

ATP HAMAP MF_00249

Secondary structure

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444

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P43773-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C346EA478E4094CE
Show »

444

49,372

        10         20         30         40         50         60 
MSEMTPREIV SELDQHIIGQ ADAKRAVAIA LRNRWRRMQL QEPLRHEVTP KNILMIGPTG 

        70         80         90        100        110        120 
VGKTEIARRL AKLANAPFIK VEATKFTEVG YVGKEVDSII RDLTDSAMKL VRQQEIAKNR 

       130        140        150        160        170        180 
ARAEDVAEER ILDALLPPAK NQWGEVENHD SHSSTRQAFR KKLREGQLDD KEIEIDVSAG 

       190        200        210        220        230        240 
VSMGVEIMAP PGMEEMTNQL QSLFQNLGSD KTKKRKMKIK DALKALIDDE AAKLINPEEL 

       250        260        270        280        290        300 
KQKAIDAVEQ NGIVFIDEID KICKKGEYSG ADVSREGVQR DLLPLVEGST VSTKHGMVKT 

       310        320        330        340        350        360 
DHILFIASGA FQVARPSDLI PELQGRLPIR VELTALSAAD FERILTEPHA SLTEQYKALM 

       370        380        390        400        410        420 
ATEGVNIAFT TDAVKKIAEA AFRVNEKTEN IGARRLHTVM ERLMDKISFS ASDMNGQTVN 

       430        440 
IDAAYVADAL GEVVENEDLS RFIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Crystal and solution structures of an HslUV protease-chaperone complex." Sousa M.C., Trame C.B., Tsuruta H., Wilbanks S.M., Reddy V.S., McKay D.B. Cell 103:633-643(2000) [PubMed: 11106733] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.41 ANGSTROMS).
[3]	"The structures of HslU and the ATP-dependent protease HslU-HslV." Bochtler M., Hartmann C., Song H.K., Bourenkov G.P., Bartunik H.D., Huber R. Nature 403:800-805(2000) [PubMed: 10693812] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC22154.1.

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G3I	X-ray	3.41	A/B/C/D/E/F/S/T/U/V/W/X	1-444	[»]
1G41	X-ray	2.30	A	1-444	[»]
1IM2	X-ray	2.80	A	1-444	[»]
1KYI	X-ray	3.10	A/B/C/D/E/F/S/T/U/V/W/X	1-444	[»]
1OFH	X-ray	2.50	A/B/C	1-444	[»]
1OFI	X-ray	3.20	A/B/C	1-444	[»]

ModBase

Protein-protein interaction databases

DIP

Genome annotation databases

GeneID

GenomeReviews

Gene locus HI0497 in contig L42023_GR.

KEGG

NMPDR

fig|71421.1.peg.468.

TIGR

Phylogenomic databases

HOGENOM

OMA

P43773. TDHVLFI.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0497-MON.

Family and domain databases

HAMAP

MF_00249.
[Tree]

InterPro

IPR003593. ATPase_AAA+_core.
IPR013093. ATPase_AAA-2.
IPR004491. HslU.
[Graphical view]

PANTHER

PTHR11262:SF3. HslU. 1 hit.

Pfam

PF07724. AAA_2. 2 hits.
[Graphical view]

SMART

SM00382. AAA. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00390. hslU. 1 hit.

ProtoNet

Entry information

Entry name

HSLU_HAEIN

Accession

Primary (citable) accession number: P43773

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents