P43770 (UDP_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine phosphorylase
Short name=UPase
Short name=UrdPase
EC=2.4.2.3

Gene names

Name:	udp
Ordered Locus Names:	HI_0280

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.
Catalytic activity	Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PNP/UDP phosphorylase family.
Sequence caution	The sequence AAC21943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway nucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	uridine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Uridine phosphorylase		PRO_0000063186

Sequences

	Sequence		Length	Mass (Da)
	P43770 [UniParc]. Last modified October 3, 2003. Version 2. Checksum: 30A007A6A764DEF6	FASTA	252	27,254
	10 20 30 40 50 60 MSGVFHLNLT KAQLKGATLA IVPGDPARSE RIAKQLDNPE FLTSTREFTS WLGYINGQPI 70 80 90 100 110 120 VVCSTGIGGP STSICVEELA QLGVRTFLRI GTTGAIQPHI NVGDVLITTA AVRLDGASHH 130 140 150 160 170 180 FVPLEYPAVA NFECTTALYN AAKAKGIEPY VGVTVSSDTF YPGQERYDTY SGKVYRNYQG 190 200 210 220 230 240 LLKQWQDLNV MNYEMESSTL FTMCSALGLR AGMVAGVIVN RTQQEIPNEA TIKQTEEKAV 250 SVVITAAQAL LS

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21943.1. Different initiation.
PIR	C64059.
RefSeq	NP_438448.2. NC_000907.1.
3D structure databases
ProteinModelPortal	P43770.
SMR	P43770. Positions 2-251.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC21943; AAC21943; HI_0280.
GeneID	950640.
KEGG	hin:HI0280.
PATRIC	20189099. VBIHaeInf48452_0296.
Phylogenomic databases
eggNOG	COG2820.
KO	K00757.
OMA	ICVEELA.
ProtClustDB	PRK11178.
Enzyme and pathway databases
UniPathway	UPA00574; UER00633.
Family and domain databases
Gene3D	3.40.50.1580. 1 hit.
InterPro	IPR018017. Nucleoside_phosphorylase. IPR018016. Nucleoside_phosphorylase_CS. IPR000845. Nucleoside_phosphorylase_d. IPR010058. Uridine_phosphorylase. [Graphical view]
PANTHER	PTHR21234. PTHR21234. 1 hit.
Pfam	PF01048. PNP_UDP_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01718. Uridine-psphlse. 1 hit.
PROSITE	PS01232. PNP_UDP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDP_HAEIN

Accession

Primary (citable) accession number: P43770

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 3, 2003
Last modified:	May 29, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program