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P43770 (UDP_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine phosphorylase

Short name=UPase
Short name=UrdPase
EC=2.4.2.3
Gene names
Name:udp
Ordered Locus Names:HI_0280
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Sequence caution

The sequence AAC21943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processUMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

nucleotide catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuridine phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Uridine phosphorylase
PRO_0000063186

Sequences

Sequence LengthMass (Da)Tools
P43770 [UniParc].

Last modified October 3, 2003. Version 2.
Checksum: 30A007A6A764DEF6

FASTA25227,254
        10         20         30         40         50         60 
MSGVFHLNLT KAQLKGATLA IVPGDPARSE RIAKQLDNPE FLTSTREFTS WLGYINGQPI 

        70         80         90        100        110        120 
VVCSTGIGGP STSICVEELA QLGVRTFLRI GTTGAIQPHI NVGDVLITTA AVRLDGASHH 

       130        140        150        160        170        180 
FVPLEYPAVA NFECTTALYN AAKAKGIEPY VGVTVSSDTF YPGQERYDTY SGKVYRNYQG 

       190        200        210        220        230        240 
LLKQWQDLNV MNYEMESSTL FTMCSALGLR AGMVAGVIVN RTQQEIPNEA TIKQTEEKAV 

       250 
SVVITAAQAL LS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21943.1. Different initiation.
PIRC64059.
RefSeqNP_438448.2. NC_000907.1.

3D structure databases

ProteinModelPortalP43770.
SMRP43770. Positions 2-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21943; AAC21943; HI_0280.
GeneID950640.
KEGGhin:HI0280.
PATRIC20189099. VBIHaeInf48452_0296.

Phylogenomic databases

eggNOGCOG2820.
KOK00757.
OMAHIACKPG.
OrthoDBEOG676Z3T.
PhylomeDBP43770.

Enzyme and pathway databases

UniPathwayUPA00574; UER00633.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010058. Uridine_phosphorylase.
[Graphical view]
PANTHERPTHR21234. PTHR21234. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01718. Uridine-psphlse. 1 hit.
PROSITEPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDP_HAEIN
AccessionPrimary (citable) accession number: P43770
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 3, 2003
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names