Reviewed, UniProtKB/Swiss-Prot P43761 (TRPE_HAEIN)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	HI1387

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity By similarity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Anthranilate synthase component 1		PRO_0000154093

Sequences

	Sequence		Length	Mass (Da)
	P43761-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D597A7D56E921409	FASTA	518	57,522
	10 20 30 40 50 60 MNIQTQAFIA VTAQPIPYYA DTTAIFNTLC QSNSNSLLLD SAEIGSKNSL QSLILVNAAV 70 80 90 100 110 120 KITCLGHNVT FKALNNNGKQ VLKEIHPKLT ALGKVSAVNF EDEFSVQFLP LDNQLDEDSK 130 140 150 160 170 180 LQSATIFDGL RVISSLYQHS QTPIFLGGLF AYDLVANFIP MDGITLKNDG INCPDYSFYL 190 200 210 220 230 240 AEHLITIDHQ NQQATLKSFC FAQEEQVNIA KTSLSIAQKL KNIDHVLSIK AASDEVKTNF 250 260 270 280 290 300 DDPEFTGIVK ALKHHINIGD VFQIVPSRRF SLACPNTLAS YAQLKQNNPS PYMFYMNDED 310 320 330 340 350 360 FILFGASPES ALKYAPENRQ LEIYPIAGSR PRGFDAHGNI DPELDARLEL ELRLDHKEQA 370 380 390 400 410 420 EHLMLVDLAR NDIARVCQSG TRKVAELMQV DRYSHIMHLV SRVVGKLRPE LDALHAYQAC 430 440 450 460 470 480 MNMGTLTGAP KIKAMQLIYQ FEQQKRHSYG GAVGYLTSDG HFDTCIVIRS AFVQNGMAHV 490 500 510 QAGCGEVLDS DPQMEADETR HKAAAVLKAI RQVNTQAK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC23033.1.
PIR	C64121.
RefSeq	NP_439539.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0G based on UniProtKB P05041.
ModBase	Search...
Genome annotation databases
GeneID	950300.
GenomeReviews	Gene locus HI1387 in contig L42023_GR.
KEGG	hin:HI1387.
NMPDR	fig|71421.1.peg.1323.
TIGR	HI1387.
Phylogenomic databases
HOGENOM	P43761.
OMA	HKELAEH.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1387-MON.
BRENDA	4.1.3.27. 109.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_HAEIN

Accession

Primary (citable) accession number: P43761

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)