P43761 (TRPE_HAEIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 93.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Anthranilate synthase component 1 EC=4.1.3.27 Alternative name(s): Anthranilate synthase component I | ||||
| Gene names |
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| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 71421 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › ![]() |
Protein attributes
| Sequence length | 518 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. |
| Pathway | Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5. |
| Subunit structure | Tetramer of two components I and two components II By similarity. |
| Miscellaneous | Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity By similarity. |
| Sequence similarities | Belongs to the anthranilate synthase component I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis |
| Molecular function | Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | anthranilate synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 518 | 518 | Anthranilate synthase component 1 | PRO_0000154093 | |||
Sequences
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References
| [1] | "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C.Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L42023 Genomic DNA. Translation: AAC23033.1. |
| PIR | C64121. |
| RefSeq | NP_439539.1. NC_000907.1. |
3D structure databases | |
| ProteinModelPortal | P43761. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 71421.HI1387. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAC23033; AAC23033; HI_1387. |
| GeneID | 950300. |
| KEGG | hin:HI1387. |
| PATRIC | 20191467. VBIHaeInf48452_1444. |
Phylogenomic databases | |
| eggNOG | COG0147. |
| KO | K01657. |
| OMA | NDIARVC. |
| ProtClustDB | PRK13564. |
Enzyme and pathway databases | |
| UniPathway | UPA00035; UER00040. |
Family and domain databases | |
| Gene3D | 3.60.120.10. 1 hit. |
| InterPro | IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005257. Anth_synth_I_TrpE. IPR015890. Chorismate-bd_C. [Graphical view] |
| Pfam | PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view] |
| PIRSF | PIRSF001373. TrpE. 1 hit. |
| PRINTS | PR00095. ANTSNTHASEI. |
| SUPFAM | SSF56322. TRPE_1_chor_bd. 1 hit. |
| TIGRFAMs | TIGR00565. trpE_proteo. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TRPE_HAEIN | ||||||||
| Accession | Primary (citable) accession number: P43761 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Haemophilus influenzae Haemophilus influenzae (strain Rd): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
