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Reviewed, UniProtKB/Swiss-Prot P43761 (TRPE_HAEIN)

Last modified November 3, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I
Gene names
Name: trpE
Ordered Locus Names: HI1387
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity By similarity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Anthranilate synthase component 1
PRO_0000154093

Sequences

Sequence LengthMass (Da)Tools
P43761-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D597A7D56E921409

FASTA51857,522
        10         20         30         40         50         60 
MNIQTQAFIA VTAQPIPYYA DTTAIFNTLC QSNSNSLLLD SAEIGSKNSL QSLILVNAAV 

        70         80         90        100        110        120 
KITCLGHNVT FKALNNNGKQ VLKEIHPKLT ALGKVSAVNF EDEFSVQFLP LDNQLDEDSK 

       130        140        150        160        170        180 
LQSATIFDGL RVISSLYQHS QTPIFLGGLF AYDLVANFIP MDGITLKNDG INCPDYSFYL 

       190        200        210        220        230        240 
AEHLITIDHQ NQQATLKSFC FAQEEQVNIA KTSLSIAQKL KNIDHVLSIK AASDEVKTNF 

       250        260        270        280        290        300 
DDPEFTGIVK ALKHHINIGD VFQIVPSRRF SLACPNTLAS YAQLKQNNPS PYMFYMNDED 

       310        320        330        340        350        360 
FILFGASPES ALKYAPENRQ LEIYPIAGSR PRGFDAHGNI DPELDARLEL ELRLDHKEQA 

       370        380        390        400        410        420 
EHLMLVDLAR NDIARVCQSG TRKVAELMQV DRYSHIMHLV SRVVGKLRPE LDALHAYQAC 

       430        440        450        460        470        480 
MNMGTLTGAP KIKAMQLIYQ FEQQKRHSYG GAVGYLTSDG HFDTCIVIRS AFVQNGMAHV 

       490        500        510 
QAGCGEVLDS DPQMEADETR HKAAAVLKAI RQVNTQAK 

« Hide

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC23033.1.
PIRC64121.
RefSeqNP_439539.1.

3D structure databases

HSSPHSSP built from PDB template 1K0G based on UniProtKB P05041.
ModBaseSearch...

Genome annotation databases

GeneID950300.
GenomeReviewsGene locus HI1387 in contig L42023_GR.
KEGGhin:HI1387.
NMPDRfig|71421.1.peg.1323.
TIGRHI1387.

Phylogenomic databases

HOGENOMP43761.
OMAHKELAEH.

Enzyme and pathway databases

BioCycHINF71421:HI_1387-MON.
BRENDA4.1.3.27. 109.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR019999. Anthranilate_synth_I_C.
IPR015890. Chorismate-bd_C.
IPR005257. TrpE_synth.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHERPTHR11236. TRPE_1_chor_bd. 1 hit.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
ProDomPD000779. Anth_synth_chor. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00565. trpE_proteo. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_HAEIN
AccessionPrimary (citable) accession number: P43761
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents