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P43761 (TRPE_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:HI_1387
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity By similarity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Anthranilate synthase component 1
PRO_0000154093

Sequences

Sequence LengthMass (Da)Tools
P43761 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D597A7D56E921409

FASTA51857,522
        10         20         30         40         50         60 
MNIQTQAFIA VTAQPIPYYA DTTAIFNTLC QSNSNSLLLD SAEIGSKNSL QSLILVNAAV 

        70         80         90        100        110        120 
KITCLGHNVT FKALNNNGKQ VLKEIHPKLT ALGKVSAVNF EDEFSVQFLP LDNQLDEDSK 

       130        140        150        160        170        180 
LQSATIFDGL RVISSLYQHS QTPIFLGGLF AYDLVANFIP MDGITLKNDG INCPDYSFYL 

       190        200        210        220        230        240 
AEHLITIDHQ NQQATLKSFC FAQEEQVNIA KTSLSIAQKL KNIDHVLSIK AASDEVKTNF 

       250        260        270        280        290        300 
DDPEFTGIVK ALKHHINIGD VFQIVPSRRF SLACPNTLAS YAQLKQNNPS PYMFYMNDED 

       310        320        330        340        350        360 
FILFGASPES ALKYAPENRQ LEIYPIAGSR PRGFDAHGNI DPELDARLEL ELRLDHKEQA 

       370        380        390        400        410        420 
EHLMLVDLAR NDIARVCQSG TRKVAELMQV DRYSHIMHLV SRVVGKLRPE LDALHAYQAC 

       430        440        450        460        470        480 
MNMGTLTGAP KIKAMQLIYQ FEQQKRHSYG GAVGYLTSDG HFDTCIVIRS AFVQNGMAHV 

       490        500        510 
QAGCGEVLDS DPQMEADETR HKAAAVLKAI RQVNTQAK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC23033.1.
PIRC64121.
RefSeqNP_439539.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43761.
ModBaseSearch...

Protein-protein interaction databases

STRING71421.HI1387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23033; AAC23033; HI_1387.
GeneID950300.
KEGGhin:HI1387.
PATRIC20191467. VBIHaeInf48452_1444.

Phylogenomic databases

eggNOGCOG0147.
KOK01657.
OMANDIARVC.
ProtClustDBPRK13564.

Enzyme and pathway databases

UniPathwayUPA00035; UER00040.

Family and domain databases

Gene3D3.60.120.10. 1 hit.
InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005257. Anth_synth_I_TrpE.
IPR015890. Chorismate-bd_C.
[Graphical view]
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PIRSFPIRSF001373. TrpE. 1 hit.
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00565. trpE_proteo. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_HAEIN
AccessionPrimary (citable) accession number: P43761
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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