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P43755

- RIR2_HAEIN

UniProt

P43755 - RIR2_HAEIN

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
Metal bindingi116 – 1161Iron 2By similarity
Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
Active sitei123 – 1231PROSITE-ProRule annotation
Metal bindingi205 – 2051Iron 2By similarity
Metal bindingi239 – 2391Iron 2By similarity
Metal bindingi242 – 2421Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:HI_1660
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 376375Ribonucleoside-diphosphate reductase subunit betaPRO_0000190479Add
BLAST

Proteomic databases

PRIDEiP43755.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi71421.HI1660.

Structurei

3D structure databases

ProteinModelPortaliP43755.
SMRiP43755. Positions 2-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.
PhylomeDBiP43755.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43755-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYTTFSQNK NDQLKEPMFF GQNVNVARYD QQKYETFEKL IEKQLSFFWR
60 70 80 90 100
PEEVDVSQDR IDYAALPEHE KHIFISNLKY QTLLDSIQGR SPNVALLPLV
110 120 130 140 150
SIPELETWIE TWTFSETIHS RSYTHIIRNI VNDPSIVFDD IVTNEEIIKR
160 170 180 190 200
AQDISSYYDD LIRDSQLYGL YGEGTYTVDG KECVVTLRSL KKQLYLCLMS
210 220 230 240 250
VNALEAIRFY VSFACSFAFA ERRLMEGNAK IIKFIARDEA LHLTGTQHIL
260 270 280 290 300
NIMAAGQDDP EMAEIAEECK QEAYDLFVAA AEQEKAWADY LFKDGSMIGL
310 320 330 340 350
NRDILVQYVE YITNIRMQAV GLPLPFQTRS NPIPWINAWL VSDNVQVAPQ
360 370
EVEVSSYLVG QIDSKVDTND FDDFSL
Length:376
Mass (Da):43,326
Last modified:January 23, 2007 - v2
Checksum:iF3B8FD9EAF9C7238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23306.1.
PIRiC64135.
RefSeqiNP_439802.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23306; AAC23306; HI_1660.
GeneIDi950858.
KEGGihin:HI1660.
PATRICi20192069. VBIHaeInf48452_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23306.1 .
PIRi C64135.
RefSeqi NP_439802.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43755.
SMRi P43755. Positions 2-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1660.

Proteomic databases

PRIDEi P43755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23306 ; AAC23306 ; HI_1660 .
GeneIDi 950858.
KEGGi hin:HI1660.
PATRICi 20192069. VBIHaeInf48452_1738.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi WIETWAF.
OrthoDBi EOG6J48J7.
PhylomeDBi P43755.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRIR2_HAEIN
AccessioniPrimary (citable) accession number: P43755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3