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P43755

- RIR2_HAEIN

UniProt

P43755 - RIR2_HAEIN

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Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
nrdB, HI_1660
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron 1 By similarity
Metal bindingi116 – 1161Iron 1 By similarity
Metal bindingi116 – 1161Iron 2 By similarity
Metal bindingi119 – 1191Iron 1 By similarity
Active sitei123 – 1231 By similarity
Metal bindingi205 – 2051Iron 2 By similarity
Metal bindingi239 – 2391Iron 2 By similarity
Metal bindingi242 – 2421Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:HI_1660
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 376375Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190479Add
BLAST

Proteomic databases

PRIDEiP43755.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi71421.HI1660.

Structurei

3D structure databases

ProteinModelPortaliP43755.
SMRiP43755. Positions 2-342.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.
PhylomeDBiP43755.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43755-1 [UniParc]FASTAAdd to Basket

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MAYTTFSQNK NDQLKEPMFF GQNVNVARYD QQKYETFEKL IEKQLSFFWR    50
PEEVDVSQDR IDYAALPEHE KHIFISNLKY QTLLDSIQGR SPNVALLPLV 100
SIPELETWIE TWTFSETIHS RSYTHIIRNI VNDPSIVFDD IVTNEEIIKR 150
AQDISSYYDD LIRDSQLYGL YGEGTYTVDG KECVVTLRSL KKQLYLCLMS 200
VNALEAIRFY VSFACSFAFA ERRLMEGNAK IIKFIARDEA LHLTGTQHIL 250
NIMAAGQDDP EMAEIAEECK QEAYDLFVAA AEQEKAWADY LFKDGSMIGL 300
NRDILVQYVE YITNIRMQAV GLPLPFQTRS NPIPWINAWL VSDNVQVAPQ 350
EVEVSSYLVG QIDSKVDTND FDDFSL 376
Length:376
Mass (Da):43,326
Last modified:January 23, 2007 - v2
Checksum:iF3B8FD9EAF9C7238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23306.1.
PIRiC64135.
RefSeqiNP_439802.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23306; AAC23306; HI_1660.
GeneIDi950858.
KEGGihin:HI1660.
PATRICi20192069. VBIHaeInf48452_1738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23306.1 .
PIRi C64135.
RefSeqi NP_439802.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43755.
SMRi P43755. Positions 2-342.
ModBasei Search...

Protein-protein interaction databases

STRINGi 71421.HI1660.

Proteomic databases

PRIDEi P43755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23306 ; AAC23306 ; HI_1660 .
GeneIDi 950858.
KEGGi hin:HI1660.
PATRICi 20192069. VBIHaeInf48452_1738.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi WIETWAF.
OrthoDBi EOG6J48J7.
PhylomeDBi P43755.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiRIR2_HAEIN
AccessioniPrimary (citable) accession number: P43755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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