Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43755 (RIR2_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:HI_1660
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 376375Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190479

Sites

Active site1231 By similarity
Metal binding851Iron 1 By similarity
Metal binding1161Iron 1 By similarity
Metal binding1161Iron 2 By similarity
Metal binding1191Iron 1 By similarity
Metal binding2051Iron 2 By similarity
Metal binding2391Iron 2 By similarity
Metal binding2421Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43755 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: F3B8FD9EAF9C7238

FASTA37643,326
        10         20         30         40         50         60 
MAYTTFSQNK NDQLKEPMFF GQNVNVARYD QQKYETFEKL IEKQLSFFWR PEEVDVSQDR 

        70         80         90        100        110        120 
IDYAALPEHE KHIFISNLKY QTLLDSIQGR SPNVALLPLV SIPELETWIE TWTFSETIHS 

       130        140        150        160        170        180 
RSYTHIIRNI VNDPSIVFDD IVTNEEIIKR AQDISSYYDD LIRDSQLYGL YGEGTYTVDG 

       190        200        210        220        230        240 
KECVVTLRSL KKQLYLCLMS VNALEAIRFY VSFACSFAFA ERRLMEGNAK IIKFIARDEA 

       250        260        270        280        290        300 
LHLTGTQHIL NIMAAGQDDP EMAEIAEECK QEAYDLFVAA AEQEKAWADY LFKDGSMIGL 

       310        320        330        340        350        360 
NRDILVQYVE YITNIRMQAV GLPLPFQTRS NPIPWINAWL VSDNVQVAPQ EVEVSSYLVG 

       370 
QIDSKVDTND FDDFSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23306.1.
PIRC64135.
RefSeqNP_439802.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43755.
SMRP43755. Positions 2-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1660.

Proteomic databases

PRIDEP43755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23306; AAC23306; HI_1660.
GeneID950858.
KEGGhin:HI1660.
PATRIC20192069. VBIHaeInf48452_1738.

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMAWIETWAF.
OrthoDBEOG6J48J7.
PhylomeDBP43755.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_HAEIN
AccessionPrimary (citable) accession number: P43755
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names