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P43755

- RIR2_HAEIN

UniProt

P43755 - RIR2_HAEIN

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 2By similarity
    Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
    Active sitei123 – 1231PROSITE-ProRule annotation
    Metal bindingi205 – 2051Iron 2By similarity
    Metal bindingi239 – 2391Iron 2By similarity
    Metal bindingi242 – 2421Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:HI_1660
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 376375Ribonucleoside-diphosphate reductase subunit betaPRO_0000190479Add
    BLAST

    Proteomic databases

    PRIDEiP43755.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1660.

    Structurei

    3D structure databases

    ProteinModelPortaliP43755.
    SMRiP43755. Positions 2-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiWIETWAF.
    OrthoDBiEOG6J48J7.
    PhylomeDBiP43755.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43755-1 [UniParc]FASTAAdd to Basket

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    MAYTTFSQNK NDQLKEPMFF GQNVNVARYD QQKYETFEKL IEKQLSFFWR    50
    PEEVDVSQDR IDYAALPEHE KHIFISNLKY QTLLDSIQGR SPNVALLPLV 100
    SIPELETWIE TWTFSETIHS RSYTHIIRNI VNDPSIVFDD IVTNEEIIKR 150
    AQDISSYYDD LIRDSQLYGL YGEGTYTVDG KECVVTLRSL KKQLYLCLMS 200
    VNALEAIRFY VSFACSFAFA ERRLMEGNAK IIKFIARDEA LHLTGTQHIL 250
    NIMAAGQDDP EMAEIAEECK QEAYDLFVAA AEQEKAWADY LFKDGSMIGL 300
    NRDILVQYVE YITNIRMQAV GLPLPFQTRS NPIPWINAWL VSDNVQVAPQ 350
    EVEVSSYLVG QIDSKVDTND FDDFSL 376
    Length:376
    Mass (Da):43,326
    Last modified:January 23, 2007 - v2
    Checksum:iF3B8FD9EAF9C7238
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23306.1.
    PIRiC64135.
    RefSeqiNP_439802.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23306; AAC23306; HI_1660.
    GeneIDi950858.
    KEGGihin:HI1660.
    PATRICi20192069. VBIHaeInf48452_1738.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23306.1 .
    PIRi C64135.
    RefSeqi NP_439802.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43755.
    SMRi P43755. Positions 2-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1660.

    Proteomic databases

    PRIDEi P43755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23306 ; AAC23306 ; HI_1660 .
    GeneIDi 950858.
    KEGGi hin:HI1660.
    PATRICi 20192069. VBIHaeInf48452_1738.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi WIETWAF.
    OrthoDBi EOG6J48J7.
    PhylomeDBi P43755.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiRIR2_HAEIN
    AccessioniPrimary (citable) accession number: P43755
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3