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P43752

- NRDD_HAEIN

UniProt

P43752 - NRDD_HAEIN

Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Gene namesi
    Name:nrdD
    Ordered Locus Names:HI_0075
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Anaerobic ribonucleoside-triphosphate reductasePRO_0000166684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei682 – 6821Glycine radicalPROSITE-ProRule annotation

    Keywords - PTMi

    Organic radical

    Interactioni

    Subunit structurei

    Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0075.

    Structurei

    3D structure databases

    ProteinModelPortaliP43752.
    SMRiP43752. Positions 124-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 9592ATP-conePROSITE-ProRule annotationAdd
    BLAST
    Domaini584 – 707124Glycine radicalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-cone domain.PROSITE-ProRule annotation
    Contains 1 glycine radical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1328.
    KOiK00527.
    OMAiKRRVKHM.
    OrthoDBiEOG622PMK.
    PhylomeDBiP43752.

    Family and domain databases

    InterProiIPR005144. ATP-cone.
    IPR019777. Form_AcTrfase_GR_CS.
    IPR001150. Gly_radical.
    IPR012833. NrdD.
    [Graphical view]
    PfamiPF03477. ATP-cone. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02487. NrdD. 1 hit.
    PROSITEiPS51161. ATP_CONE. 1 hit.
    PS00850. GLY_RADICAL_1. 1 hit.
    PS51149. GLY_RADICAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43752-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE    50
    IFTRHQGEID INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ 100
    LTKEIEGLIE QSNVELLNEN ANKDAKVIPT QRDLLAGIVA KHYAKHNILP 150
    RDVVEAHEKG EIHYHDLDYA PFFPMFNCML VDLEGMLSRG FKMGNAEIEP 200
    PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ ISYEKHLKHA 250
    QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL 300
    GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY 350
    DIKQLALECA SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE 400
    IHDGRNNLGV VSLNLPRIAL ESKNEEDFYR TLDERLAIAK KALMTRIARL 450
    ENTKARVAPI LYMEGACGVR LKADENVAQI FKNGRASISL GYIGIHETIN 500
    ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF SLYSTPSENL 550
    CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP 600
    LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF 650
    TGEFECTSKG FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV 700
    KRRVKHL 707
    Length:707
    Mass (Da):80,233
    Last modified:November 1, 1995 - v1
    Checksum:iA3795F7921A6781D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21751.1.
    PIRiA64047.
    RefSeqiNP_438248.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21751; AAC21751; HI_0075.
    GeneIDi950970.
    KEGGihin:HI0075.
    PATRICi20188605. VBIHaeInf48452_0076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21751.1 .
    PIRi A64047.
    RefSeqi NP_438248.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43752.
    SMRi P43752. Positions 124-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21751 ; AAC21751 ; HI_0075 .
    GeneIDi 950970.
    KEGGi hin:HI0075.
    PATRICi 20188605. VBIHaeInf48452_0076.

    Phylogenomic databases

    eggNOGi COG1328.
    KOi K00527.
    OMAi KRRVKHM.
    OrthoDBi EOG622PMK.
    PhylomeDBi P43752.

    Family and domain databases

    InterProi IPR005144. ATP-cone.
    IPR019777. Form_AcTrfase_GR_CS.
    IPR001150. Gly_radical.
    IPR012833. NrdD.
    [Graphical view ]
    Pfami PF03477. ATP-cone. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02487. NrdD. 1 hit.
    PROSITEi PS51161. ATP_CONE. 1 hit.
    PS00850. GLY_RADICAL_1. 1 hit.
    PS51149. GLY_RADICAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiNRDD_HAEIN
    AccessioniPrimary (citable) accession number: P43752
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3