Reviewed, UniProtKB/Swiss-Prot P43752 (NRDD_HAEIN)

Names and origin

Protein names

Recommended name:
    Anaerobic ribonucleoside-triphosphate reductase
    EC=1.17.4.2

Gene names

Name:	nrdD
Ordered Locus Names:	HI0075

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.
Subunit structure	Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits By similarity.
Sequence similarities	Belongs to the anaerobic ribonucleoside-triphosphate reductase family. Contains 1 ATP-cone domain. Contains 1 glycine radical domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Oxidoreductase
PTM	Organic radical
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside-triphosphate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 707	707	Anaerobic ribonucleoside-triphosphate reductase		PRO_0000166684
Regions
	Domain	4 – 95	92	ATP-cone
	Domain	584 – 707	124	Glycine radical
Amino acid modifications
	Modified residue	682	1	Glycine radical By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43752-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A3795F7921A6781D	FASTA	707	80,233
	10 20 30 40 50 60 MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE IFTRHQGEID 70 80 90 100 110 120 INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ LTKEIEGLIE QSNVELLNEN 130 140 150 160 170 180 ANKDAKVIPT QRDLLAGIVA KHYAKHNILP RDVVEAHEKG EIHYHDLDYA PFFPMFNCML 190 200 210 220 230 240 VDLEGMLSRG FKMGNAEIEP PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ 250 260 270 280 290 300 ISYEKHLKHA QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL 310 320 330 340 350 360 GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY DIKQLALECA 370 380 390 400 410 420 SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE IHDGRNNLGV VSLNLPRIAL 430 440 450 460 470 480 ESKNEEDFYR TLDERLAIAK KALMTRIARL ENTKARVAPI LYMEGACGVR LKADENVAQI 490 500 510 520 530 540 FKNGRASISL GYIGIHETIN ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF 550 560 570 580 590 600 SLYSTPSENL CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP 610 620 630 640 650 660 LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF TGEFECTSKG 670 680 690 700 FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV KRRVKHL

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21751.1.
PIR	A64047.
RefSeq	NP_438248.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950970.
GenomeReviews	Gene locus HI0075 in contig L42023_GR.
KEGG	hin:HI0075.
NMPDR	fig|71421.1.peg.74.
TIGR	HI0075.
Phylogenomic databases
HOGENOM	P43752.
OMA	HGEDEES
Enzyme and pathway databases
BioCyc	HINF71421:HI_0075-MON.
BRENDA	1.17.4.2. 109.
Family and domain databases
InterPro	IPR005144. ATP-cone. IPR001150. Form_AcTrfase_GR. IPR019777. Form_AcTrfase_GR_CS. IPR012833. NrdD. [Graphical view]
Pfam	PF03477. ATP-cone. 1 hit. PF01228. Gly_radical. 1 hit. [Graphical view]
TIGRFAMs	TIGR02487. NrdD. 1 hit.
PROSITE	PS51161. ATP_CONE. 1 hit. PS00850. GLY_RADICAL_1. 1 hit. PS51149. GLY_RADICAL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRDD_HAEIN

Accession

Primary (citable) accession number: P43752

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)