Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair.By similarity

Catalytic activityi

Ribonucleoside 5'-triphosphate + formate = 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O.By similarity

Enzyme regulationi

Activated under anaerobic conditions by NrdG, a tightly associated activase. Activation involves the formation of a glycyl radical at Gly-682.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi645ZincBy similarity1
Metal bindingi648ZincBy similarity1
Metal bindingi663ZincBy similarity1
Metal bindingi666ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductaseBy similarity (EC:1.1.98.6By similarity)
Alternative name(s):
Class III ribonucleoside-triphosphate reductaseBy similarity
Gene namesi
Name:nrdD
Ordered Locus Names:HI_0075
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001666841 – 707Anaerobic ribonucleoside-triphosphate reductaseAdd BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei682Glycine radicalPROSITE-ProRule annotation1

Keywords - PTMi

Organic radical

Interactioni

Subunit structurei

Forms a tetramer composed of two NrdD and two NrdG subunits.By similarity

Protein-protein interaction databases

STRINGi71421.HI0075.

Structurei

3D structure databases

ProteinModelPortaliP43752.
SMRiP43752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 95ATP-conePROSITE-ProRule annotationAdd BLAST92
Domaini584 – 707Glycine radicalPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CJD. Bacteria.
COG1328. LUCA.
KOiK21636.
OMAiQSEWAGA.
PhylomeDBiP43752.

Family and domain databases

CDDicd01675. RNR_III. 1 hit.
InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF13597. NRDD. 1 hit.
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P43752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE
60 70 80 90 100
IFTRHQGEID INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ
110 120 130 140 150
LTKEIEGLIE QSNVELLNEN ANKDAKVIPT QRDLLAGIVA KHYAKHNILP
160 170 180 190 200
RDVVEAHEKG EIHYHDLDYA PFFPMFNCML VDLEGMLSRG FKMGNAEIEP
210 220 230 240 250
PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ ISYEKHLKHA
260 270 280 290 300
QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL
310 320 330 340 350
GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY
360 370 380 390 400
DIKQLALECA SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE
410 420 430 440 450
IHDGRNNLGV VSLNLPRIAL ESKNEEDFYR TLDERLAIAK KALMTRIARL
460 470 480 490 500
ENTKARVAPI LYMEGACGVR LKADENVAQI FKNGRASISL GYIGIHETIN
510 520 530 540 550
ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF SLYSTPSENL
560 570 580 590 600
CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP
610 620 630 640 650
LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF
660 670 680 690 700
TGEFECTSKG FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV

KRRVKHL
Length:707
Mass (Da):80,233
Last modified:November 1, 1995 - v1
Checksum:iA3795F7921A6781D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21751.1.
PIRiA64047.
RefSeqiNP_438248.1. NC_000907.1.
WP_005693847.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21751; AAC21751; HI_0075.
GeneIDi950970.
KEGGihin:HI0075.
PATRICifig|71421.8.peg.76.

Similar proteinsi

Entry informationi

Entry nameiNRDD_HAEIN
AccessioniPrimary (citable) accession number: P43752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families