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P43752

- NRDD_HAEIN

UniProt

P43752 - NRDD_HAEIN

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Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene
nrdD, HI_0075
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Gene namesi
Name:nrdD
Ordered Locus Names:HI_0075
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Anaerobic ribonucleoside-triphosphate reductasePRO_0000166684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei682 – 6821Glycine radical By similarity

Keywords - PTMi

Organic radical

Interactioni

Subunit structurei

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits By similarity.

Protein-protein interaction databases

STRINGi71421.HI0075.

Structurei

3D structure databases

ProteinModelPortaliP43752.
SMRiP43752. Positions 124-670.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9592ATP-coneAdd
BLAST
Domaini584 – 707124Glycine radicalAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-cone domain.

Phylogenomic databases

eggNOGiCOG1328.
KOiK00527.
OMAiKRRVKHM.
OrthoDBiEOG622PMK.
PhylomeDBiP43752.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43752-1 [UniParc]FASTAAdd to Basket

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MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE    50
IFTRHQGEID INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ 100
LTKEIEGLIE QSNVELLNEN ANKDAKVIPT QRDLLAGIVA KHYAKHNILP 150
RDVVEAHEKG EIHYHDLDYA PFFPMFNCML VDLEGMLSRG FKMGNAEIEP 200
PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ ISYEKHLKHA 250
QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL 300
GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY 350
DIKQLALECA SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE 400
IHDGRNNLGV VSLNLPRIAL ESKNEEDFYR TLDERLAIAK KALMTRIARL 450
ENTKARVAPI LYMEGACGVR LKADENVAQI FKNGRASISL GYIGIHETIN 500
ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF SLYSTPSENL 550
CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP 600
LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF 650
TGEFECTSKG FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV 700
KRRVKHL 707
Length:707
Mass (Da):80,233
Last modified:November 1, 1995 - v1
Checksum:iA3795F7921A6781D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21751.1.
PIRiA64047.
RefSeqiNP_438248.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21751; AAC21751; HI_0075.
GeneIDi950970.
KEGGihin:HI0075.
PATRICi20188605. VBIHaeInf48452_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC21751.1 .
PIRi A64047.
RefSeqi NP_438248.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43752.
SMRi P43752. Positions 124-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21751 ; AAC21751 ; HI_0075 .
GeneIDi 950970.
KEGGi hin:HI0075.
PATRICi 20188605. VBIHaeInf48452_0076.

Phylogenomic databases

eggNOGi COG1328.
KOi K00527.
OMAi KRRVKHM.
OrthoDBi EOG622PMK.
PhylomeDBi P43752.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view ]
Pfami PF03477. ATP-cone. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02487. NrdD. 1 hit.
PROSITEi PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNRDD_HAEIN
AccessioniPrimary (citable) accession number: P43752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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