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P43752 (NRDD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anaerobic ribonucleoside-triphosphate reductase
EC=1.17.4.2
Gene names
Name:nrdD
Ordered Locus Names:HI_0075
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Subunit structure

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits By similarity.

Sequence similarities

Belongs to the anaerobic ribonucleoside-triphosphate reductase family.

Contains 1 ATP-cone domain.

Contains 1 glycine radical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707Anaerobic ribonucleoside-triphosphate reductase
PRO_0000166684

Regions

Domain4 – 9592ATP-cone
Domain584 – 707124Glycine radical

Amino acid modifications

Modified residue6821Glycine radical By similarity

Sequences

Sequence LengthMass (Da)Tools
P43752 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A3795F7921A6781D

FASTA70780,233
        10         20         30         40         50         60 
MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE IFTRHQGEID 

        70         80         90        100        110        120 
INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ LTKEIEGLIE QSNVELLNEN 

       130        140        150        160        170        180 
ANKDAKVIPT QRDLLAGIVA KHYAKHNILP RDVVEAHEKG EIHYHDLDYA PFFPMFNCML 

       190        200        210        220        230        240 
VDLEGMLSRG FKMGNAEIEP PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ 

       250        260        270        280        290        300 
ISYEKHLKHA QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL 

       310        320        330        340        350        360 
GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY DIKQLALECA 

       370        380        390        400        410        420 
SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE IHDGRNNLGV VSLNLPRIAL 

       430        440        450        460        470        480 
ESKNEEDFYR TLDERLAIAK KALMTRIARL ENTKARVAPI LYMEGACGVR LKADENVAQI 

       490        500        510        520        530        540 
FKNGRASISL GYIGIHETIN ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF 

       550        560        570        580        590        600 
SLYSTPSENL CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP 

       610        620        630        640        650        660 
LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF TGEFECTSKG 

       670        680        690        700 
FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV KRRVKHL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC21751.1.
PIRA64047.
RefSeqNP_438248.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43752.
SMRP43752. Positions 124-670.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950970.
GenomeReviewsGene locus HI_0075 in contig L42023_GR.
KEGGhin:HI0075.
NMPDRfig|71421.1.peg.74.
PATRIC20188605. VBIHaeInf48452_0076.
TIGRHI_0075.

Phylogenomic databases

HOGENOMHBG297080.
OMANNTRGEE.
ProtClustDBPRK09263.

Enzyme and pathway databases

BioCycHINF71421:HI_0075-MONOMER.

Family and domain databases

InterProIPR005144. ATP-cone.
IPR001150. Form_AcTrfase_GR.
IPR019777. Form_AcTrfase_GR_CS.
IPR012833. NrdD.
[Graphical view]
KOK00527.
PfamPF03477. ATP-cone. 1 hit.
PF01228. Gly_radical. 1 hit.
[Graphical view]
TIGRFAMsTIGR02487. NrdD. 1 hit.
PROSITEPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNRDD_HAEIN
AccessionPrimary (citable) accession number: P43752
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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