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P43752

- NRDD_HAEIN

UniProt

P43752 - NRDD_HAEIN

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Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Gene namesi
Name:nrdD
Ordered Locus Names:HI_0075
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Anaerobic ribonucleoside-triphosphate reductasePRO_0000166684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei682 – 6821Glycine radicalPROSITE-ProRule annotation

Keywords - PTMi

Organic radical

Interactioni

Subunit structurei

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.By similarity

Protein-protein interaction databases

STRINGi71421.HI0075.

Structurei

3D structure databases

ProteinModelPortaliP43752.
SMRiP43752. Positions 124-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9592ATP-conePROSITE-ProRule annotationAdd
BLAST
Domaini584 – 707124Glycine radicalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-cone domain.PROSITE-ProRule annotation
Contains 1 glycine radical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1328.
KOiK00527.
OMAiKRRVKHM.
OrthoDBiEOG622PMK.
PhylomeDBiP43752.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43752-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNFGVIKRD GSRAEFEIQR IINAIKKAAS AVNISDEFYC HQIGQEVGNE
60 70 80 90 100
IFTRHQGEID INQIQKIVED KLMASRYPEV ARAYIEYRHD RDLAREKRSQ
110 120 130 140 150
LTKEIEGLIE QSNVELLNEN ANKDAKVIPT QRDLLAGIVA KHYAKHNILP
160 170 180 190 200
RDVVEAHEKG EIHYHDLDYA PFFPMFNCML VDLEGMLSRG FKMGNAEIEP
210 220 230 240 250
PKSIGTATAV TAQIIAQVAS HIYGGTTINR IDEVLSPYVQ ISYEKHLKHA
260 270 280 290 300
QEWNVPDVEG YAKALIEKEC FDAFQSLEYE VNTLHTSNGQ TPFVTFGFGL
310 320 330 340 350
GTSWQSRLIQ QAILKNRIRG LGKNHKTPVF PKLVFTIKKG LNQNKGDPNY
360 370 380 390 400
DIKQLALECA SKRMYPDILN YDQVVKVTGS FKAPMGCRSF LGAYEEKGHE
410 420 430 440 450
IHDGRNNLGV VSLNLPRIAL ESKNEEDFYR TLDERLAIAK KALMTRIARL
460 470 480 490 500
ENTKARVAPI LYMEGACGVR LKADENVAQI FKNGRASISL GYIGIHETIN
510 520 530 540 550
ALYNKGHIFD DEQLREKGIA IVRHLSEAVK RWQKETGYAF SLYSTPSENL
560 570 580 590 600
CDRFCRLDTK KFGVIEGVTD KGYYTNSYHL DVEKKVNPYD KLDFEMTYPP
610 620 630 640 650
LASGGFICYG EYPNIQHNLK ALEDVWDYSY DRVPYYGTNT PIDECYECGF
660 670 680 690 700
TGEFECTSKG FVCPKCGNHD STKVSVTRRV CGYLGSPDAR PFNAGKQEEV

KRRVKHL
Length:707
Mass (Da):80,233
Last modified:November 1, 1995 - v1
Checksum:iA3795F7921A6781D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21751.1.
PIRiA64047.
RefSeqiNP_438248.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC21751; AAC21751; HI_0075.
GeneIDi950970.
KEGGihin:HI0075.
PATRICi20188605. VBIHaeInf48452_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC21751.1 .
PIRi A64047.
RefSeqi NP_438248.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43752.
SMRi P43752. Positions 124-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC21751 ; AAC21751 ; HI_0075 .
GeneIDi 950970.
KEGGi hin:HI0075.
PATRICi 20188605. VBIHaeInf48452_0076.

Phylogenomic databases

eggNOGi COG1328.
KOi K00527.
OMAi KRRVKHM.
OrthoDBi EOG622PMK.
PhylomeDBi P43752.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view ]
Pfami PF03477. ATP-cone. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02487. NrdD. 1 hit.
PROSITEi PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiNRDD_HAEIN
AccessioniPrimary (citable) accession number: P43752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3