P43750 (HOLD_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase III subunit psi
EC=2.7.7.7

Gene names

Name:	holD
Ordered Locus Names:	HI_0011

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit structure	DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Ontologies

Keywords
Biological process	DNA replication
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	DNA polymerase III subunit psi		PRO_0000105521

Sequences

	Sequence		Length	Mass (Da)
	P43750 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EFBFED319F5B8623	FASTA	134	15,718
	10 20 30 40 50 60 MNRRDLLLQE MGISQWELYR PEVLQGSVGI SVAENIRLIT VSDENISSSP LLADVLLSLN 70 80 90 100 110 120 LKKENCLCLN YDQIQHMECK QPIRYWLLSE NSDQIDRTLP FCKQAEQVYR SPSWQQFQSN 130 HQAKRALWQQ IQQP

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21689.1.
PIR	E64042.
RefSeq	NP_438184.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43750.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950908.
GenomeReviews	Gene locus HI_0011 in contig L42023_GR.
KEGG	hin:HI0011.
NMPDR	fig|71421.1.peg.10.
PATRIC	20188473. VBIHaeInf48452_0011.
TIGR	HI_0011.
Phylogenomic databases
HOGENOM	HBG636949.
OMA	KPQVLKG.
ProtClustDB	PRK06856.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0011-MONOMER.
Family and domain databases
InterPro	IPR004615. DNA_pol_III_psi. IPR018382. DNA_pol_III_psi_subgr. [Graphical view]
Gene3D	G3DSA:3.40.50.10220. DNA_pol_III_psi. 1 hit.
KO	K02344.
Pfam	PF03603. DNA_III_psi. 1 hit. [Graphical view]
PIRSF	PIRSF029225. DNA_pol_III_psi. 1 hit.
SUPFAM	SSF102220. DNA_pol_III_psi. 1 hit.
TIGRFAMs	TIGR00664. DNA_III_psi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HOLD_HAEIN

Accession

Primary (citable) accession number: P43750

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program