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P43749

- HOLC_HAEIN

UniProt

P43749 - HOLC_HAEIN

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Protein

DNA polymerase III subunit chi

Gene

holC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit chi (EC:2.7.7.7)
Gene namesi
Name:holC
Ordered Locus Names:HI_1397
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144DNA polymerase III subunit chiPRO_0000105518Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi71421.HI1397.

Structurei

3D structure databases

ProteinModelPortaliP43749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2927.
KOiK02339.
OMAiWQFEPSA.
OrthoDBiEOG68H887.
PhylomeDBiP43749.

Family and domain databases

Gene3Di3.40.50.10110. 1 hit.
InterProiIPR007459. DNA_pol3_chi.
[Graphical view]
PfamiPF04364. DNA_pol3_chi. 1 hit.
[Graphical view]
SUPFAMiSSF102400. SSF102400. 1 hit.

Sequencei

Sequence statusi: Complete.

P43749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTAQFYIL TENCTLTVEE IACNLAASIW RSGKKVLISC ESEAQALEID
60 70 80 90 100
ERLWQRDPNE FVPHNLSGEA TQYPTPIEIS WLGKRNLQRR DLLINLQQEI
110 120 130 140
PDFSHSFTQI IDFVPKDDAL KTQARERYKQ LRLQGWNLST ENVG
Length:144
Mass (Da):16,636
Last modified:November 1, 1995 - v1
Checksum:iA4571B90253C9D45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23044.1.
L15391 Genomic DNA. Translation: AAA61957.1.
PIRiI64121.
RefSeqiNP_439550.1. NC_000907.1.
WP_005693964.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23044; AAC23044; HI_1397.
GeneIDi950308.
KEGGihin:HI1397.
PATRICi20191493. VBIHaeInf48452_1457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23044.1 .
L15391 Genomic DNA. Translation: AAA61957.1 .
PIRi I64121.
RefSeqi NP_439550.1. NC_000907.1.
WP_005693964.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43749.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1397.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23044 ; AAC23044 ; HI_1397 .
GeneIDi 950308.
KEGGi hin:HI1397.
PATRICi 20191493. VBIHaeInf48452_1457.

Phylogenomic databases

eggNOGi COG2927.
KOi K02339.
OMAi WQFEPSA.
OrthoDBi EOG68H887.
PhylomeDBi P43749.

Family and domain databases

Gene3Di 3.40.50.10110. 1 hit.
InterProi IPR007459. DNA_pol3_chi.
[Graphical view ]
Pfami PF04364. DNA_pol3_chi. 1 hit.
[Graphical view ]
SUPFAMi SSF102400. SSF102400. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Cloning, analysis and expression of the HindIII R-M-encoding genes."
    Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G.
    Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-144.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiHOLC_HAEIN
AccessioniPrimary (citable) accession number: P43749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names

External Data

Dasty 3