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P43749 (HOLC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit chi

EC=2.7.7.7
Gene names
Name:holC
Ordered Locus Names:HI_1397
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144DNA polymerase III subunit chi
PRO_0000105518

Sequences

Sequence LengthMass (Da)Tools
P43749 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A4571B90253C9D45

FASTA14416,636
        10         20         30         40         50         60 
MAKTAQFYIL TENCTLTVEE IACNLAASIW RSGKKVLISC ESEAQALEID ERLWQRDPNE 

        70         80         90        100        110        120 
FVPHNLSGEA TQYPTPIEIS WLGKRNLQRR DLLINLQQEI PDFSHSFTQI IDFVPKDDAL 

       130        140 
KTQARERYKQ LRLQGWNLST ENVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23044.1.
L15391 Genomic DNA. Translation: AAA61957.1.
PIRI64121.
RefSeqNP_439550.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43749.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23044; AAC23044; HI_1397.
GeneID950308.
KEGGhin:HI1397.
PATRIC20191493. VBIHaeInf48452_1457.

Phylogenomic databases

eggNOGCOG2927.
KOK02339.
OMAWQFEPSA.
OrthoDBEOG68H887.
ProtClustDBPRK05728.

Family and domain databases

Gene3D3.40.50.10110. 1 hit.
InterProIPR007459. DNA_pol3_chi.
[Graphical view]
PfamPF04364. DNA_pol3_chi. 1 hit.
[Graphical view]
SUPFAMSSF102400. SSF102400. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHOLC_HAEIN
AccessionPrimary (citable) accession number: P43749
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names