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P43749

- HOLC_HAEIN

UniProt

P43749 - HOLC_HAEIN

Protein

DNA polymerase III subunit chi

Gene

holC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit chi (EC:2.7.7.7)
    Gene namesi
    Name:holC
    Ordered Locus Names:HI_1397
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144DNA polymerase III subunit chiPRO_0000105518Add
    BLAST

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1397.

    Structurei

    3D structure databases

    ProteinModelPortaliP43749.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2927.
    KOiK02339.
    OMAiWQFEPSA.
    OrthoDBiEOG68H887.
    PhylomeDBiP43749.

    Family and domain databases

    Gene3Di3.40.50.10110. 1 hit.
    InterProiIPR007459. DNA_pol3_chi.
    [Graphical view]
    PfamiPF04364. DNA_pol3_chi. 1 hit.
    [Graphical view]
    SUPFAMiSSF102400. SSF102400. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTAQFYIL TENCTLTVEE IACNLAASIW RSGKKVLISC ESEAQALEID    50
    ERLWQRDPNE FVPHNLSGEA TQYPTPIEIS WLGKRNLQRR DLLINLQQEI 100
    PDFSHSFTQI IDFVPKDDAL KTQARERYKQ LRLQGWNLST ENVG 144
    Length:144
    Mass (Da):16,636
    Last modified:November 1, 1995 - v1
    Checksum:iA4571B90253C9D45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23044.1.
    L15391 Genomic DNA. Translation: AAA61957.1.
    PIRiI64121.
    RefSeqiNP_439550.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23044; AAC23044; HI_1397.
    GeneIDi950308.
    KEGGihin:HI1397.
    PATRICi20191493. VBIHaeInf48452_1457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23044.1 .
    L15391 Genomic DNA. Translation: AAA61957.1 .
    PIRi I64121.
    RefSeqi NP_439550.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43749.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1397.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23044 ; AAC23044 ; HI_1397 .
    GeneIDi 950308.
    KEGGi hin:HI1397.
    PATRICi 20191493. VBIHaeInf48452_1457.

    Phylogenomic databases

    eggNOGi COG2927.
    KOi K02339.
    OMAi WQFEPSA.
    OrthoDBi EOG68H887.
    PhylomeDBi P43749.

    Family and domain databases

    Gene3Di 3.40.50.10110. 1 hit.
    InterProi IPR007459. DNA_pol3_chi.
    [Graphical view ]
    Pfami PF04364. DNA_pol3_chi. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102400. SSF102400. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Cloning, analysis and expression of the HindIII R-M-encoding genes."
      Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G.
      Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-144.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiHOLC_HAEIN
    AccessioniPrimary (citable) accession number: P43749
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names

    External Data

    Dasty 3