P43749 (HOLC_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase III subunit chi
EC=2.7.7.7

Gene names

Name:	holC
Ordered Locus Names:	HI_1397

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit structure	DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Ontologies

Keywords
Biological process	DNA replication
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	DNA polymerase III subunit chi		PRO_0000105518

Sequences

	Sequence		Length	Mass (Da)
	P43749 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A4571B90253C9D45	FASTA	144	16,636
	10 20 30 40 50 60 MAKTAQFYIL TENCTLTVEE IACNLAASIW RSGKKVLISC ESEAQALEID ERLWQRDPNE 70 80 90 100 110 120 FVPHNLSGEA TQYPTPIEIS WLGKRNLQRR DLLINLQQEI PDFSHSFTQI IDFVPKDDAL 130 140 KTQARERYKQ LRLQGWNLST ENVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Cloning, analysis and expression of the HindIII R-M-encoding genes." Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F., Benner J.S., Wilson G.G. Gene 150:75-80(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-144. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23044.1. L15391 Genomic DNA. Translation: AAA61957.1.
PIR	I64121.
RefSeq	NP_439550.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43749.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI1397.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC23044; AAC23044; HI_1397.
GeneID	950308.
KEGG	hin:HI1397.
PATRIC	20191493. VBIHaeInf48452_1457.
Phylogenomic databases
eggNOG	COG2927.
KO	K02339.
OMA	NLADQVP.
ProtClustDB	PRK05728.
Family and domain databases
Gene3D	3.40.50.10110. 1 hit.
InterPro	IPR007459. DNA_pol3_chi. [Graphical view]
Pfam	PF04364. DNA_pol3_chi. 1 hit. [Graphical view]
SUPFAM	SSF102400. DNA_pol3_chi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HOLC_HAEIN

Accession

Primary (citable) accession number: P43749

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program