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P43738 (RPOB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:HI_0515
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length1343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13431343DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000047906

Sequences

Sequence LengthMass (Da)Tools
P43738 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4EF99CD648686A44

FASTA1,343149,784
        10         20         30         40         50         60 
MGYSYSEKKR IRKDFGKRPQ VLNVPYLLTI QLDSFDKFIQ KDPEGQQGLE AAFRSVFPIV 

        70         80         90        100        110        120 
SNNGYTELQY VDYRLEEPEF DVRECQIRGS TYAAGLRVKL RLVSYDKESS SRAVKDIKEN 

       130        140        150        160        170        180 
EVYMGEIPLM TDNGTFVING TERVIVSQLH RSPGVFFDSD KGKTHSSGKV LYNARIIPYR 

       190        200        210        220        230        240 
GSWLDFEFDP KDNLFARIDR RRKLPATIIL RALGYTTEEI LNLFFDKITF EIAGDKLLMT 

       250        260        270        280        290        300 
LVPERLRGET ASFDIEANGK VYVERGRRIT ARHIKALEKD NISQVVVPSE YILGKVASKD 

       310        320        330        340        350        360 
YVDLESGEII CPANGEISLE TLAKLAQAGY TTIETLFTND LDYGPYISET LRVDPTYDKT 

       370        380        390        400        410        420 
SALYEIYRMM RPGEPPTPES SEALFNNLFF SAERYDLSTV GRMKFNRSLA FPEGEGAGIL 

       430        440        450        460        470        480 
SNEDIIAVMR KLIDIRNGRG EVDDIDHLGN RRIRSVGEMA ENQFRIGLVR VERAVKERLS 

       490        500        510        520        530        540 
LGDLDAITPQ DLINPKPISA AVKEFFGSSQ LSQFMDQNNP LSEVTHKRRI SALGPGGLTR 

       550        560        570        580        590        600 
ERAGFEVRDV HNTHYGRLCP IETPEGPNIG LINSLSAFAR TNDYGFLETP YRKVVDGQVT 

       610        620        630        640        650        660 
EEIEYLSVID EANYIIAQAN SNLDENNRFT DAFVTARGER GESGLYKPED IHYMDVSTQQ 

       670        680        690        700        710        720 
VVSVAAALIP FLEHDDANRA LMGANMQRQA VPTLRADKPL VGTGMEKPIA LDSGVAVVAK 

       730        740        750        760        770        780 
RGGTVQYVDA SRIVIKVNED ETIAGEAGID IYNLIKYTRS NQNTCINQIP CVNLGDPINR 

       790        800        810        820        830        840 
GEVLADGPST DLGELALGQN IRVAFMPWNG YNFEDSMLVS ERVVQQDRFT TIHIQELSCV 

       850        860        870        880        890        900 
ARDTKLGAEE ITADIPNVGE SALSKLDESG IVYVGAEVKG GDILVGKVTP KGETQLTPEE 

       910        920        930        940        950        960 
KLLRAIFGEK ASDVKDSSLR VPNGTSGTVI DVQVFTRDGV EKDKRALEIE EMQLREAKKD 

       970        980        990       1000       1010       1020 
LTEELEILEA GLFARVRNLL ISSGADAAQL DKLDRTKWLE QTIADEEKQN QLEQLAEQYE 

      1030       1040       1050       1060       1070       1080 
ELRKEFEHKL EVKRKKIIKG DDLAPGVLKV VKVYLAVKRQ IQPGDKMAGR HGNKGVISKI 

      1090       1100       1110       1120       1130       1140 
NPVEDMPYDE NGQPVEIVLN PLGVPSRMNI GQILETHLGL AAKGIGDQIN AMLKQKQEVE 

      1150       1160       1170       1180       1190       1200 
KLRSYIQKAY DLLGNGSQKV DLSTFTDEEV LRLAGNLRKG LPVATPVFDG ADEAEIKELL 

      1210       1220       1230       1240       1250       1260 
KLGGLPTSGQ ITLYDGRTGE KFERPVTVGY MYMLKLNHLV DDKMHARSTG SYSLVTQQPL 

      1270       1280       1290       1300       1310       1320 
GGKAQFGGQR FGEMEVWALE AYGAAYTLQE MLTVKSDDVN GRTKMYKNIV SGNQHMEPGT 

      1330       1340 
PESFNVIMKE IRSLGLNIEL DEE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22173.1.
PIRH64073.
RefSeqNP_438673.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43738.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID949581.
GenomeReviewsGene locus HI_0515 in contig L42023_GR.
KEGGhin:HI0515.
NMPDRfig|71421.1.peg.486.
PATRIC20189583. VBIHaeInf48452_0534.
TIGRHI_0515.

Phylogenomic databases

HOGENOMHBG285547.
OMAIGRNKTY.
PhylomeDBP43738.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycHINF71421:HI_0515-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 2 hits.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_HAEIN
AccessionPrimary (citable) accession number: P43738
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

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