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Protein

60 kDa chaperonin

Gene

groL

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:HI_0543
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633871 – 54860 kDa chaperoninAdd BLAST548

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi71421.HI0543.

Structurei

3D structure databases

ProteinModelPortaliP43733.
SMRiP43733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiTDTDKME.
PhylomeDBiP43733.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

P43733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN DARVKMLKGV NVLADAVKVT LGPKGRHVIL DKSFGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVSAVVSE LKNLSKPCET AKEIEQVGTI
160 170 180 190 200
SANSDSIVGQ LISQAMEKVG KEGVITVEDG TGLEDELDVV EGMQFDRGYL
210 220 230 240 250
SPYFINKPET ATVELDNPYL LLVDKKISNI RELLPVLEGV AKAGKPLLII
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAILTAGTV
310 320 330 340 350
ISEEIGMELE KATLEDLGQA KRVVINKDNT TIIDGIGDEA QIKGRVAQIR
360 370 380 390 400
QQIEESTSDY DKEKLQERVA KLAGGVAVIK VGAATEVEMK EKKDRVDDAL
410 420 430 440 450
HATRAAVEEG IVAGGGVALV RAAAKVAASL KGDNEEQNVG IKLALRAMEA
460 470 480 490 500
PLRQIVTNAG EEASVVASAV KNGEGNFGYN AGTEQYGDMI EMGILDPTKV
510 520 530 540
TRSALQFAAS VAGLMITTEC MVTDLPKDDK ADLGAAGMGG MGGMGGMM
Length:548
Mass (Da):57,577
Last modified:November 1, 1995 - v1
Checksum:iCA4066AAC1B62159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22201.1.
PIRiC64076.
RefSeqiNP_438701.1. NC_000907.1.
WP_010869002.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22201; AAC22201; HI_0543.
GeneIDi950072.
KEGGihin:HI0543.
PATRICifig|71421.8.peg.562.

Similar proteinsi

Entry informationi

Entry nameiCH60_HAEIN
AccessioniPrimary (citable) accession number: P43733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families