Reviewed, UniProtKB/Swiss-Prot P43731 (UNG_HAEIN)

Names and origin

Protein names

Recommended name:
    Uracil-DNA glycosylase
      Short name=UDG
    EC=3.2.2.-

Gene names

Name:	ung
Ordered Locus Names:	HI0018

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uracil DNA N-glycosylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Uracil-DNA glycosylase HAMAP MF_00148		PRO_0000176100
Sites
	Active site	61	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43731-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: C270CC31F7B2E58A	FASTA	219	24,848
	10 20 30 40 50 60 MKNWTDVIGT EKAQPYFQHT LQQVHLARAS GKTIYPPQED VFNAFKYTAF EDVKVVILGQ 70 80 90 100 110 120 DPYHGPNQAH GLAFSVKPEV AIPPSLLNIY KELTQDISGF QMPSNGYLVK WAEQGVLLLN 130 140 150 160 170 180 TVLTVERGMA HSHANLGWER FTDKVIAVLN EHREKLVFLL WGSHAQKKGQ MIDRTRHLVL 190 200 210 TAPHPSPLSA HRGFFGCRHF SKTNSYLESH GIKPIDWQI

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21696.1.
PIR	A64043.
RefSeq	NP_438191.1.
3D structure databases
SMR	P43731. Positions 4-217.
ModBase	Search...
Genome annotation databases
GeneID	950914.
GenomeReviews	Gene locus HI0018 in contig L42023_GR.
KEGG	hin:HI0018.
NMPDR	fig|71421.1.peg.17.
TIGR	HI0018.
Phylogenomic databases
HOGENOM	HBG605450.
OMA	YLVKWAE.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0018-MON.
Family and domain databases
HAMAP	MF_00148. [Tree]
InterPro	IPR002043. UDNA_glycsylse. IPR018085. Ura-DNA_Glyclase_AS. IPR005122. Uracil-DNA_glycosylase-like. [Graphical view]
Gene3D	G3DSA:3.40.470.10. Uracil-DNA_glycosylase-like. 1 hit.
PANTHER	PTHR11264. UDNA_glycsylse. 1 hit.
Pfam	PF03167. UDG. 1 hit. [Graphical view]
PROSITE	PS00130. U_DNA_GLYCOSYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UNG_HAEIN

Accession

Primary (citable) accession number: P43731

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 15, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)