Reviewed, UniProtKB/Swiss-Prot P43729 (LEPA_HAEIN)

Names and origin

Protein names

Recommended name:
    GTP-binding protein lepA

Gene names

Name:	lepA
Ordered Locus Names:	HI0016

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Cell membrane By similarity. Periplasm By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. LepA subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Periplasm
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	GTP-binding protein lepA HAMAP MF_00071		PRO_0000176280
Regions
	Nucleotide binding	11 – 18	8	GTP By similarity
	Nucleotide binding	77 – 81	5	GTP By similarity
	Nucleotide binding	131 – 134	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43729-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: FDDB1AC3516BF11E	FASTA	598	66,333
	10 20 30 40 50 60 MKNIRNFSII AHIDHGKSTL SDRLIQTCGG LSDREMEAQV LDSMDLERER GITIKAQSVT 70 80 90 100 110 120 LNYKAKDGET YQLNFIDTPG HVDFSYEVSR SLAACEGALL VVDAGQGVEA QTLANCYTAI 130 140 150 160 170 180 EMDLEVVPIL NKIDLPAADP ERVAEEIEDI VGIDAMEAVR CSAKTGVGIE DVLEEIVAKI 190 200 210 220 230 240 PAPEGDPNAP LQALIIDSWF DNYLGVVSLV RIKNGVLRKG DKIKVMSTGQ TYNVDRLGIF 250 260 270 280 290 300 TPKQEDTTVL ECGEVGWVVC AIKDILGAPV GDTLTHQHNS ATEVLPGFKK VKPQVYAGLF 310 320 330 340 350 360 PVSSDDYEAF RDALGKLSLN DASLFYEPET STALGFGFRC GFLGLLHMEI IQERLEREYD 370 380 390 400 410 420 LDLITTAPTV IYEVEMTNGE VVYVDSPAKL PPLNNIAEIR EPIAECNMLV PQEYLGNVIT 430 440 450 460 470 480 LCVEKRGVQT NMVYHGNQIA LTYEIPMGEV VLDFFDRLKS TSRGYASLDY GFKRFQAADM 490 500 510 520 530 540 VRVDIMINSE RVDALALIVH KDNSQYRGRE LVEKMRELIP RQQFDIAIQA AIGNHIIARS 550 560 570 580 590 TVKQLRKNVL AKCYGGDVSR KKKLLQKQKE GKKRMKSLGN VEVPQEAFLA ILHVGKDK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21694.1.
PIR	I64042.
RefSeq	NP_438189.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	950909.
GenomeReviews	Gene locus HI0016 in contig L42023_GR.
KEGG	hin:HI0016.
NMPDR	fig|71421.1.peg.15.
TIGR	HI0016.
Phylogenomic databases
HOGENOM	HBG286375.
OMA	EVVTDFF.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0016-MON.
Family and domain databases
HAMAP	MF_00071. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR006297. LepA_GTP_bd. IPR013842. LepA_GTP_bd_C. IPR000795. ProtSyn_GTP_bd. IPR005225. Small_GTP_bd. IPR000640. Transl_elong_EFG/EF2_C. IPR004161. Transl_elong_EFTu/EF1A_2. [Graphical view]
Gene3D	G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
Pfam	PF00679. EFG_C. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF06421. LepA_C. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. [Graphical view]
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LEPA_HAEIN

Accession

Primary (citable) accession number: P43729

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 15, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)