Reviewed, UniProtKB/Swiss-Prot P43728 (ERA_HAEIN)

Names and origin

Protein names

Recommended name:
    GTP-binding protein era homolog

Gene names

Name:	era
Ordered Locus Names:	HI0013

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds both GDP and GTP, has an intrinsic GTPase activity and is essential for cell growth By similarity.
Sequence similarities	Belongs to the era/mnmE GTP-binding protein family. Era subfamily. Contains 1 KH type-2 domain.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: HAMAP RNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	GTP-binding protein era homolog HAMAP MF_00367		PRO_0000180017
Regions
	Domain	208 – 285	78	KH type-2
	Nucleotide binding	17 – 24	8	GTP Potential
	Nucleotide binding	64 – 68	5	GTP Potential
	Nucleotide binding	126 – 129	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	P43728-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: ACD724D8A3170328	FASTA	302	34,354
	10 20 30 40 50 60 MTEQFDKTYC GFIAIVGRPN VGKSTLLNKI LGQKISITSR KAQTTRHRIV GIKTEGAYQE 70 80 90 100 110 120 IYVDTPGLHI EEKRAINRLM NRAASSAIGD VDLIIFVVDG THWNADDEMV LNKLRNAKAP 130 140 150 160 170 180 VVLAINKVDN IKNKDDLLPF ITDLSSKFNF AHIVPISAQR GNNVHELEKI VRQSLREGVH 190 200 210 220 230 240 HFPEDYVTDR SQRFMASEII REKLMRFTGE ELPYSVTVEI EQFKVNERGT YEINGLILVE 250 260 270 280 290 300 REGQKKMVIG AGGQKIKTIG MEARADMERL FDNKVHLELW VKVKSGWADD ERALRSLGYM DE

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21691.1.
PIR	F64042.
RefSeq	NP_438186.1.
3D structure databases
SMR	P43728. Positions 6-298.
ModBase	Search...
Genome annotation databases
GeneID	950911.
GenomeReviews	Gene locus HI0013 in contig L42023_GR.
KEGG	hin:HI0013.
TIGR	HI0013.
Phylogenomic databases
HOGENOM	P43728.
OMA	GIHKPHH
Enzyme and pathway databases
BioCyc	HINF71421:HI_0013-MON.
Family and domain databases
HAMAP	MF_00367. [Tree]
InterPro	IPR005662. Era_GTP_bd. IPR006073. GTP1_OBG. IPR015946. KH-like_a/b. IPR004044. KH_type_2. IPR002917. MMR_HSR1_GTP_bd. IPR005225. Small_GTP_bd. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
PRINTS	PR00326. GTP1OBG.
TIGRFAMs	TIGR00436. era. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_HAEIN

Accession

Primary (citable) accession number: P43728

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)