P43728 (ERA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Era

Gene names

Name:	era
Ordered Locus Names:	HI_0013

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP MF_00367
Subunit structure	Monomer By similarity. HAMAP MF_00367
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00367.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. Contains 1 G (guanine nucleotide-binding) domain. Contains 1 KH type-2 domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding RNA-binding rRNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	GTPase Era HAMAP MF_00367		PRO_0000180017
Regions
	Domain	22 – 127	106	G
	Domain	208 – 285	78	KH type-2
	Nucleotide binding	17 – 24	8	GTP Potential
	Nucleotide binding	64 – 68	5	GTP Potential
	Nucleotide binding	126 – 129	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	P43728 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: ACD724D8A3170328	FASTA	302	34,354
	10 20 30 40 50 60 MTEQFDKTYC GFIAIVGRPN VGKSTLLNKI LGQKISITSR KAQTTRHRIV GIKTEGAYQE 70 80 90 100 110 120 IYVDTPGLHI EEKRAINRLM NRAASSAIGD VDLIIFVVDG THWNADDEMV LNKLRNAKAP 130 140 150 160 170 180 VVLAINKVDN IKNKDDLLPF ITDLSSKFNF AHIVPISAQR GNNVHELEKI VRQSLREGVH 190 200 210 220 230 240 HFPEDYVTDR SQRFMASEII REKLMRFTGE ELPYSVTVEI EQFKVNERGT YEINGLILVE 250 260 270 280 290 300 REGQKKMVIG AGGQKIKTIG MEARADMERL FDNKVHLELW VKVKSGWADD ERALRSLGYM DE

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC21691.1.
PIR	F64042.
RefSeq	NP_438186.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43728.
SMR	P43728. Positions 6-298.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950911.
GenomeReviews	Gene locus HI_0013 in contig L42023_GR.
KEGG	hin:HI0013.
PATRIC	20188477. VBIHaeInf48452_0013.
TIGR	HI_0013.
Phylogenomic databases
HOGENOM	HBG561652.
OMA	KVAKDWQ.
PhylomeDB	P43728.
ProtClustDB	PRK00089.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0013-MONOMER.
Family and domain databases
HAMAP	MF_00367. GTPase_Era. [Tree]
InterPro	IPR005662. GTP-bd_Era. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR009019. KH_prok-type. IPR004044. KH_type_2. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03595.
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
PRINTS	PR00326. GTP1OBG.
SUPFAM	SSF54814. KH_prok. 1 hit.
TIGRFAMs	TIGR00436. Era. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_HAEIN

Accession

Primary (citable) accession number: P43728

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program